Risk of extracolonic malignancies and metachronous rectal cancer after colectomy and ileorectal anastomosis in familial adenomatous polyposis
Copyright © 2021. Published by Elsevier Taiwan LLC..
BACKGROUND: Analysis of long-term clinical outcomes of patients with familial adenomatous polyposis is critical in reducing or preventing the incidence of extracolonic malignancies after initial surgery. The aim of the present study was to clarify the long-term outcomes, and establish a surveillance strategy for surgically treated familial adenomatous polyposis patients.
METHODS: Between January 1967 and March 2020, retrospective data were collected from 37 patients with familial adenomatous polyposis treated or monitored in our department. Occurrence of metachronous cancers, including rectal cancers and extracolonic malignancies, and other diseases was analyzed.
RESULTS: The median follow-up duration after the first surgery was 13.8 years. Initially, 16 patients underwent total proctocolectomy with ileal pouch-anal anastomosis, 18 underwent total colectomy with ileorectal anastomosis, and three underwent other procedures. A secondary proctectomy was performed for 9 of the 18 patients who underwent ileorectal anastomosis. Rectal cancer was diagnosed in 6 patients who underwent ileorectal anastomosis. In addition, 5 gastric cancer, 2 duodenal cancer, 1 gallbladder cancer, and 1 thyroid cancer cases were diagnosed. The age at which the extracolonic malignancies were diagnosed was >50 years. 4 patients died due to metachronous rectal cancer, gastric cancer, or gallbladder cancer.
CONCLUSION: Careful consideration should be paid before choosing ileorectal anastomosis as the treatment procedure for familial adenomatous polyposis patients because completion proctectomy was eventually necessary for half of the patients. Long-term surveillance, with more frequent gastric surveillance for patients over 50 years, is important for the prevention and treatment of extracolonic malignancies in familial adenomatous polyposis patients.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:45 |
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| Enthalten in: |
Asian journal of surgery - 45(2022), 1 vom: 16. Jan., Seite 396-400 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Sasaki, Kazuhito [VerfasserIn] |
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| Links: |
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| Themen: |
Extra-colonic malignancies |
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| Anmerkungen: |
Date Completed 05.01.2022 Date Revised 05.01.2022 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.asjsur.2021.06.034 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM328751758 |
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| 100 | 1 | |a Sasaki, Kazuhito |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Risk of extracolonic malignancies and metachronous rectal cancer after colectomy and ileorectal anastomosis in familial adenomatous polyposis |
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| 500 | |a Date Revised 05.01.2022 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2021. Published by Elsevier Taiwan LLC. | ||
| 520 | |a BACKGROUND: Analysis of long-term clinical outcomes of patients with familial adenomatous polyposis is critical in reducing or preventing the incidence of extracolonic malignancies after initial surgery. The aim of the present study was to clarify the long-term outcomes, and establish a surveillance strategy for surgically treated familial adenomatous polyposis patients | ||
| 520 | |a METHODS: Between January 1967 and March 2020, retrospective data were collected from 37 patients with familial adenomatous polyposis treated or monitored in our department. Occurrence of metachronous cancers, including rectal cancers and extracolonic malignancies, and other diseases was analyzed | ||
| 520 | |a RESULTS: The median follow-up duration after the first surgery was 13.8 years. Initially, 16 patients underwent total proctocolectomy with ileal pouch-anal anastomosis, 18 underwent total colectomy with ileorectal anastomosis, and three underwent other procedures. A secondary proctectomy was performed for 9 of the 18 patients who underwent ileorectal anastomosis. Rectal cancer was diagnosed in 6 patients who underwent ileorectal anastomosis. In addition, 5 gastric cancer, 2 duodenal cancer, 1 gallbladder cancer, and 1 thyroid cancer cases were diagnosed. The age at which the extracolonic malignancies were diagnosed was >50 years. 4 patients died due to metachronous rectal cancer, gastric cancer, or gallbladder cancer | ||
| 520 | |a CONCLUSION: Careful consideration should be paid before choosing ileorectal anastomosis as the treatment procedure for familial adenomatous polyposis patients because completion proctectomy was eventually necessary for half of the patients. Long-term surveillance, with more frequent gastric surveillance for patients over 50 years, is important for the prevention and treatment of extracolonic malignancies in familial adenomatous polyposis patients | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Extra-colonic malignancies | |
| 650 | 4 | |a Familial adenomatous polyposis | |
| 650 | 4 | |a Metachronous rectal cancer | |
| 700 | 1 | |a Nozawa, Hiroaki |e verfasserin |4 aut | |
| 700 | 1 | |a Kawai, Kazushige |e verfasserin |4 aut | |
| 700 | 1 | |a Murono, Koji |e verfasserin |4 aut | |
| 700 | 1 | |a Emoto, Shigenobu |e verfasserin |4 aut | |
| 700 | 1 | |a Kishikawa, Junko |e verfasserin |4 aut | |
| 700 | 1 | |a Ishii, Hiroaki |e verfasserin |4 aut | |
| 700 | 1 | |a Yokoyama, Yuichiro |e verfasserin |4 aut | |
| 700 | 1 | |a Abe, Shinya |e verfasserin |4 aut | |
| 700 | 1 | |a Nagai, Yuzo |e verfasserin |4 aut | |
| 700 | 1 | |a Anzai, Hiroyuki |e verfasserin |4 aut | |
| 700 | 1 | |a Sonoda, Hirofumi |e verfasserin |4 aut | |
| 700 | 1 | |a Taira, Tetsuro |e verfasserin |4 aut | |
| 700 | 1 | |a Ishihara, Soichiro |e verfasserin |4 aut | |
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