Suppression of Osteoarthritis progression by post-natal Induction of Nkx3.2
Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved..
Osteoarthritis (OA) is an incurable joint disease affecting 240 million elderly population, and major unmet medical needs exist for better therapeutic options for OA. During skeletal development, Nkx3.2 has been shown to promote chondrocyte differentiation and survival, but to suppress cartilage hypertrophy and blood vessel invasion. Here we show that Nkx3.2 plays a key role in osteoarthritis (OA) pathogenesis. Marked reduction of Nkx3.2 expression was observed in three different murine OA models. Consistent with these findings, analyses of surgery-induced and age-driven OA models revealed that cartilage-specific post-natal induction of Nkx3.2 can suppress OA progression in mice. These results suggest that Nkx3.2 may serve as a promising target for OA drug development.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:571 |
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| Enthalten in: |
Biochemical and biophysical research communications - 571(2021) vom: 24. Sept., Seite 188-194 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Oh, Hye-Kyoung [VerfasserIn] |
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| Links: |
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| Themen: |
Homeodomain Proteins |
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| Anmerkungen: |
Date Completed 17.11.2021 Date Revised 17.11.2021 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.bbrc.2021.07.074 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM328746541 |
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| 520 | |a Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved. | ||
| 520 | |a Osteoarthritis (OA) is an incurable joint disease affecting 240 million elderly population, and major unmet medical needs exist for better therapeutic options for OA. During skeletal development, Nkx3.2 has been shown to promote chondrocyte differentiation and survival, but to suppress cartilage hypertrophy and blood vessel invasion. Here we show that Nkx3.2 plays a key role in osteoarthritis (OA) pathogenesis. Marked reduction of Nkx3.2 expression was observed in three different murine OA models. Consistent with these findings, analyses of surgery-induced and age-driven OA models revealed that cartilage-specific post-natal induction of Nkx3.2 can suppress OA progression in mice. These results suggest that Nkx3.2 may serve as a promising target for OA drug development | ||
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| 700 | 1 | |a Kim, Byoung Ju |e verfasserin |4 aut | |
| 700 | 1 | |a Kim, Jeong-Ah |e verfasserin |4 aut | |
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| 700 | 1 | |a Lee, Jimin |e verfasserin |4 aut | |
| 700 | 1 | |a Cho, Yongsik |e verfasserin |4 aut | |
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| 700 | 1 | |a Min, Byoung-Hyun |e verfasserin |4 aut | |
| 700 | 1 | |a Kim, Dae-Won |e verfasserin |4 aut | |
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