The genetic structure of SARS-CoV-2 is consistent with both natural or laboratory origin : Response to Tyshkovskiy and Panchin (10.1002/bies.202000325)

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Tyshkovskiy and Panchin have recently published a commentary on our paper in which they outline several "points of disagreement with the Segreto/Deigin hypothesis." As our paper is titled "The genetic structure of SARS-CoV-2 does not rule out a laboratory origin," points of disagreement should provide evidence that rules out a laboratory origin. However, Tyshkovskiy and Panchin provide no such evidence and instead attempt to criticize our arguments that highlight aspects of SARS-CoV-2 that could be consistent with the lab leak hypothesis. Strikingly, Tyshkovskiy and Panchin's main point of criticism is based on a false premise that we have claimed RaTG13 to be a direct progenitor of SARS-CoV-2, and their other points of criticism are either not valid, based on flawed mathematical analysis, or are unrelated to our hypotheses. Thus, the genetic structure of SARS-CoV-2 remains consistent with both natural or laboratory origin, which means that both the zoonotic and the lab leak hypothesis need to be investigated equally thoroughly.

Medienart:

E-Artikel

Erscheinungsjahr:

2021

Erschienen:

2021

Enthalten in:

Zur Gesamtaufnahme - volume:43

Enthalten in:

BioEssays : news and reviews in molecular, cellular and developmental biology - 43(2021), 9 vom: 19. Sept., Seite e2100137

Sprache:

Englisch

Beteiligte Personen:

Deigin, Yuri [VerfasserIn]
Segreto, Rossana [VerfasserIn]

Links:

Volltext

Themen:

Covid origins
Furin cleavage site
Gain-of-function
Journal Article
MP789
Pangolin CoV
RaTG13
SARS-CoV-2
Spike Glycoprotein, Coronavirus

Anmerkungen:

Date Completed 06.09.2021

Date Revised 06.09.2021

published: Print-Electronic

Citation Status MEDLINE

doi:

10.1002/bies.202100137

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM32872341X