Mural Endocarditis : The GAMES Registry Series and Review of the Literature
© 2021. The Author(s)..
INTRODUCTION: Mural infective endocarditis (MIE) is a rare type of endovascular infection. We present a comprehensive series of patients with mural endocarditis.
METHODS: Patients with infectious endocarditis (IE) from 35 Spanish hospitals were prospectively included in the GAMES registry between 2008 and 2017. MIEs were compared to non-MIEs. We also performed a literature search for cases of MIE published between 1979 and 2019 and compared them to the GAMEs series.
RESULTS: Twenty-seven MIEs out of 3676 IEs were included. When compared to valvular IE (VIE) or device-associated IE (DIE), patients with MIE were younger (median age 59 years, p < 0.01). Transplantation (18.5% versus 1.6% VIE and 2% DIE, p < 0.01), hemodialysis (18.5% versus 4.3% VIE and 4.4% DIE, p = 0.006), catheter source (59.3% versus 9.7% VIE and 8.8% DIE, p < 0.01) and Candida etiology (22.2% versus 2% DIE and 1.2% VIE, p < 0.01) were more common in MIE, whereas the Charlson Index was lower (4 versus 5 in non-MIE, p = 0.006). Mortality was similar. MIE from the literature shared many characteristics with MIE from GAMES, although patients were younger (45 years vs. 56 years, p < 0.001), the Charlson Index was lower (1.3 vs. 4.3, p = 0.0001), catheter source was less common (13.9% vs. 59.3%) and there were more IVDUs (25% vs. 3.7%). S. aureus was the most frequent microorganism (50%, p = 0.035). Systemic complications were more common but mortality was similar.
CONCLUSION: MIE is a rare entity. It is often a complication of catheter use, particularly in immunocompromised and hemodialysis patients. Fungal etiology is common. Mortality is similar to other IEs.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:10 |
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| Enthalten in: |
Infectious diseases and therapy - 10(2021), 4 vom: 26. Dez., Seite 2749-2764 |
| Sprache: |
Englisch |
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| Anmerkungen: |
Date Revised 17.11.2021 published: Print-Electronic Citation Status PubMed-not-MEDLINE |
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| doi: |
10.1007/s40121-021-00490-y |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM32857581X |
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| 041 | |a eng | ||
| 100 | 1 | |a Gutiérrez-Villanueva, Andrea |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Mural Endocarditis |b The GAMES Registry Series and Review of the Literature |
| 264 | 1 | |c 2021 | |
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| 500 | |a Date Revised 17.11.2021 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a © 2021. The Author(s). | ||
| 520 | |a INTRODUCTION: Mural infective endocarditis (MIE) is a rare type of endovascular infection. We present a comprehensive series of patients with mural endocarditis | ||
| 520 | |a METHODS: Patients with infectious endocarditis (IE) from 35 Spanish hospitals were prospectively included in the GAMES registry between 2008 and 2017. MIEs were compared to non-MIEs. We also performed a literature search for cases of MIE published between 1979 and 2019 and compared them to the GAMEs series | ||
| 520 | |a RESULTS: Twenty-seven MIEs out of 3676 IEs were included. When compared to valvular IE (VIE) or device-associated IE (DIE), patients with MIE were younger (median age 59 years, p < 0.01). Transplantation (18.5% versus 1.6% VIE and 2% DIE, p < 0.01), hemodialysis (18.5% versus 4.3% VIE and 4.4% DIE, p = 0.006), catheter source (59.3% versus 9.7% VIE and 8.8% DIE, p < 0.01) and Candida etiology (22.2% versus 2% DIE and 1.2% VIE, p < 0.01) were more common in MIE, whereas the Charlson Index was lower (4 versus 5 in non-MIE, p = 0.006). Mortality was similar. MIE from the literature shared many characteristics with MIE from GAMES, although patients were younger (45 years vs. 56 years, p < 0.001), the Charlson Index was lower (1.3 vs. 4.3, p = 0.0001), catheter source was less common (13.9% vs. 59.3%) and there were more IVDUs (25% vs. 3.7%). S. aureus was the most frequent microorganism (50%, p = 0.035). Systemic complications were more common but mortality was similar | ||
| 520 | |a CONCLUSION: MIE is a rare entity. It is often a complication of catheter use, particularly in immunocompromised and hemodialysis patients. Fungal etiology is common. Mortality is similar to other IEs | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Endocarditis | |
| 650 | 4 | |a Mural | |
| 650 | 4 | |a Non-valvular endocarditis | |
| 700 | 1 | |a Muñoz, Patricia |e verfasserin |4 aut | |
| 700 | 1 | |a Delgado-Montero, Antonia |e verfasserin |4 aut | |
| 700 | 1 | |a Olmedo-Samperio, María |e verfasserin |4 aut | |
| 700 | 1 | |a de Alarcón, Arístides |e verfasserin |4 aut | |
| 700 | 1 | |a Gutiérrez-Carretero, Encarnación |e verfasserin |4 aut | |
| 700 | 1 | |a Zarauza, Jesús |e verfasserin |4 aut | |
| 700 | 1 | |a García I Pares, Delia |e verfasserin |4 aut | |
| 700 | 1 | |a Goenaga, Miguel Ángel |e verfasserin |4 aut | |
| 700 | 1 | |a Ojeda-Burgos, Guillermo |e verfasserin |4 aut | |
| 700 | 1 | |a Goikoetxea-Agirre, Ane Josune |e verfasserin |4 aut | |
| 700 | 1 | |a Reguera-Iglesias, José Mª |e verfasserin |4 aut | |
| 700 | 1 | |a Ramos, Antonio |e verfasserin |4 aut | |
| 700 | 1 | |a Fernández-Cruz, Ana |e verfasserin |4 aut | |
| 700 | 0 | |a Spanish Collaboration on Endocarditis—Grupo de Apoyo al Manejo de la Endocarditis infecciosa en España (GAMES) |e verfasserin |4 aut | |
| 700 | 1 | |a Fernández-Sánchez, Fernando |e investigator |4 oth | |
| 700 | 1 | |a García de Lomas, José Mª |e investigator |4 oth | |
| 700 | 1 | |a Rosas, Gabriel |e investigator |4 oth | |
| 700 | 1 | |a de la Torre Lima, Javier |e investigator |4 oth | |
| 700 | 1 | |a Bereciartua, Elena |e investigator |4 oth | |
| 700 | 1 | |a Blanco-Vidal, María José |e investigator |4 oth | |
| 700 | 1 | |a Blanco, Roberto |e investigator |4 oth | |
| 700 | 1 | |a Boado, María Victoria |e investigator |4 oth | |
| 700 | 1 | |a Campaña-Lázaro, Marta |e investigator |4 oth | |
| 700 | 1 | |a Crespo, Alejandro |e investigator |4 oth | |
| 700 | 1 | |a Guio-Carrión, Laura |e investigator |4 oth | |
| 700 | 1 | |a Del Álamo Martínez-Lagos, Mikel |e investigator |4 oth | |
| 700 | 1 | |a Euba-Ugarte, Gorane |e investigator |4 oth | |
| 700 | 1 | |a Goikoetxea, Ane Josune |e investigator |4 oth | |
| 700 | 1 | |a Ibarrola-Hierro, Marta |e investigator |4 oth | |
| 700 | 1 | |a Iruretagoyena, José Ramón |e investigator |4 oth | |
| 700 | 1 | |a Irurzun-Zuazabal, Josu |e investigator |4 oth | |
| 700 | 1 | |a López-Soria, Leire |e investigator |4 oth | |
| 700 | 1 | |a Montejo, Miguel |e investigator |4 oth | |
| 700 | 1 | |a Nieto, Javier |e investigator |4 oth | |
| 700 | 1 | |a Rodrigo, David |e investigator |4 oth | |
| 700 | 1 | |a Rodríguez, Regino |e investigator |4 oth | |
| 700 | 1 | |a Vitoria, Yolanda |e investigator |4 oth | |
| 700 | 1 | |a Voces, Roberto |e investigator |4 oth | |
| 700 | 1 | |a García-López, Mª Victoria |e investigator |4 oth | |
| 700 | 1 | |a Georgieva, Radka Ivanova |e investigator |4 oth | |
| 700 | 1 | |a Ojeda, Guillermo |e investigator |4 oth | |
| 700 | 1 | |a Rodríguez-Bailón, Isabel |e investigator |4 oth | |
| 700 | 1 | |a Ruiz-Morales, Josefa |e investigator |4 oth | |
| 700 | 1 | |a Azkune-Galparsoro, Harkaitz |e investigator |4 oth | |
| 700 | 1 | |a Berritu-Boronat, Elisa |e investigator |4 oth | |
| 700 | 1 | |a Bustinduy-Odriozola, Mª Jesús |e investigator |4 oth | |
| 700 | 1 | |a Del Bosque Martín, Cristina |e investigator |4 oth | |
| 700 | 1 | |a Echeverría, Tomás |e investigator |4 oth | |
| 700 | 1 | |a Eizaguirre-Yarza, Alberto |e investigator |4 oth | |
| 700 | 1 | |a Fuentes, Ana |e investigator |4 oth | |
| 700 | 1 | |a Goenaga, Miguel Ángel |e investigator |4 oth | |
| 700 | 1 | |a Goyeneche Del Río, Muskilda |e investigator |4 oth | |
| 700 | 1 | |a Granda-Bauza, Ángela |e investigator |4 oth | |
| 700 | 1 | |a Iribarren, José Antonio |e investigator |4 oth | |
| 700 | 1 | |a Kortajarena-Urkola, Xabier |e investigator |4 oth | |
| 700 | 1 | |a Pérez-Moreiras López, José Ignacio |e investigator |4 oth | |
| 700 | 1 | |a Rengel-Jiménez, Ainhoa |e investigator |4 oth | |
| 700 | 1 | |a Reviejo, Karlos |e investigator |4 oth | |
| 700 | 1 | |a Sáez-Berbejillo, Alberto |e investigator |4 oth | |
| 700 | 1 | |a Sánchez-Haza, Elou |e investigator |4 oth | |
| 700 | 1 | |a Sebastián-Alda, Rosa |e investigator |4 oth | |
| 700 | 1 | |a Solla-Ruiz, Itziar |e investigator |4 oth | |
| 700 | 1 | |a Unamuno-Ugartemendia, Irati |e investigator |4 oth | |
| 700 | 1 | |a Anza, Diego Vicente |e investigator |4 oth | |
| 700 | 1 | |a Villanueva-Benito, Iñaki |e investigator |4 oth | |
| 700 | 1 | |a Zabalo-Arrieta, Mar |e investigator |4 oth | |
| 700 | 1 | |a Carrasco, Rafael |e investigator |4 oth | |
| 700 | 1 | |a Climent, Vicente |e investigator |4 oth | |
| 700 | 1 | |a Llamas, Patricio |e investigator |4 oth | |
| 700 | 1 | |a Merino, Esperanza |e investigator |4 oth | |
| 700 | 1 | |a Plazas, Joaquín |e investigator |4 oth | |
| 700 | 1 | |a Reus, Sergio |e investigator |4 oth | |
| 700 | 1 | |a Álvarez, Nemesio |e investigator |4 oth | |
| 700 | 1 | |a Bravo-Ferrer, José María |e investigator |4 oth | |
| 700 | 1 | |a Castelo, Laura |e investigator |4 oth | |
| 700 | 1 | |a Cuenca, José |e investigator |4 oth | |
| 700 | 1 | |a Llinares, Pedro |e investigator |4 oth | |
| 700 | 1 | |a Miguez-Rey, Enrique |e investigator |4 oth | |
| 700 | 1 | |a Rodríguez-Mayo, María |e investigator |4 oth | |
| 700 | 1 | |a Sánchez, Efrén |e investigator |4 oth | |
| 700 | 1 | |a Sousa-Regueiro, Dolores |e investigator |4 oth | |
| 700 | 1 | |a Martínez, Francisco Javier |e investigator |4 oth | |
| 700 | 1 | |a Del Mar Alonso, Mª |e investigator |4 oth | |
| 700 | 1 | |a Castro, Beatriz |e investigator |4 oth | |
| 700 | 1 | |a Delgado-Melian, Teresa |e investigator |4 oth | |
| 700 | 1 | |a Fernández-Sarabia, Javier |e investigator |4 oth | |
| 700 | 1 | |a García-Rosado, Dácil |e investigator |4 oth | |
| 700 | 1 | |a González-González, Julia |e investigator |4 oth | |
| 700 | 1 | |a Lacalzada, Juan |e investigator |4 oth | |
| 700 | 1 | |a Lorenzo de la Peña, Lissete |e investigator |4 oth | |
| 700 | 1 | |a Pérez-Ramírez, Alina |e investigator |4 oth | |
| 700 | 1 | |a Prada-Arrondo, Pablo |e investigator |4 oth | |
| 700 | 1 | |a Rodríguez-Moreno, Fermín |e investigator |4 oth | |
| 700 | 1 | |a Plata-Ciezar, Antonio |e investigator |4 oth | |
| 700 | 1 | |a Reguera-Iglesias, José Mª |e investigator |4 oth | |
| 700 | 1 | |a Asensi-Álvarez, Víctor |e investigator |4 oth | |
| 700 | 1 | |a Costas, Carlos |e investigator |4 oth | |
| 700 | 1 | |a de la Hera, Jesús |e investigator |4 oth | |
| 700 | 1 | |a Fernández-Suárez, Jonnathan |e investigator |4 oth | |
| 700 | 1 | |a Iglesias-Fraile, Lisardo |e investigator |4 oth | |
| 700 | 1 | |a León-Arguero, Víctor |e investigator |4 oth | |
| 700 | 1 | |a López-Menéndez, José |e investigator |4 oth | |
| 700 | 1 | |a Mencia-Bajo, Pilar |e investigator |4 oth | |
| 700 | 1 | |a Morales, Carlos |e investigator |4 oth | |
| 700 | 1 | |a Moreno-Torrico, Alfonso |e investigator |4 oth | |
| 700 | 1 | |a Palomo, Carmen |e investigator |4 oth | |
| 700 | 1 | |a Paya-Martínez, Begoña |e investigator |4 oth | |
| 700 | 1 | |a Rodríguez-Esteban, Ángeles |e investigator |4 oth | |
| 700 | 1 | |a Rodríguez-García, Raquel |e investigator |4 oth | |
| 700 | 1 | |a Telenti-Asensio, Mauricio |e investigator |4 oth | |
| 700 | 1 | |a Almela, Manuel |e investigator |4 oth | |
| 700 | 1 | |a Ambrosioni, Juan |e investigator |4 oth | |
| 700 | 1 | |a Azqueta, Manuel |e investigator |4 oth | |
| 700 | 1 | |a Brunet, Mercè |e investigator |4 oth | |
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