COVID-19 clinical phenotypes and short-term outcomes : differences between the first and the second wave of pandemic in Italy
Objectives: There are no comparative studies between patients belonging to the first and second waves of the SARS-CoV-2 pandemic, the virus triggering coronavirus disease 2019 (COVID-19). In this retrospective observational study, we analyzed the clinical characteristics and the short-term outcomes of two groups of laboratory-confirmed COVID-19 patients with moderate-to-severe acute respiratory distress syndrome (ARDS) belonging to two different waves of the pandemic. Methods: We analyzed 97 consecutive patients from 11 March 2020 to 31 May 2020 and 52 consecutive patients from 28 August 2020 to 15 October 2020. Results: Patients belonging to the second wave were younger, had a lower number of concomitant chronic conditions (multimorbidity), and had a milder clinical phenotype. Medical treatments and respiratory support use have changed during the COVID-19 pandemic, based on different laboratory results and disease clinical features. Patients in the second wave had better short-term clinical outcomes, with lower death rates and more step-down transfers to a general ward. Conclusion: The present findings show a clear phenotypic difference in patients hospitalized at different stages of the COVID-19 pandemic in Italy. These results can help to stratify clinical risk and to better tailor medical treatments and respiratory support for patients with ARDS and COVID-19 pneumonia.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:15 |
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| Enthalten in: |
Expert review of respiratory medicine - 15(2021), 12 vom: 31. Dez., Seite 1619-1625 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Portacci, Andrea [VerfasserIn] |
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| Links: |
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| Themen: |
Assisted ventilation |
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| Anmerkungen: |
Date Completed 13.12.2021 Date Revised 14.12.2021 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1080/17476348.2021.1960824 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM328564141 |
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| 500 | |a Date Revised 14.12.2021 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Objectives: There are no comparative studies between patients belonging to the first and second waves of the SARS-CoV-2 pandemic, the virus triggering coronavirus disease 2019 (COVID-19). In this retrospective observational study, we analyzed the clinical characteristics and the short-term outcomes of two groups of laboratory-confirmed COVID-19 patients with moderate-to-severe acute respiratory distress syndrome (ARDS) belonging to two different waves of the pandemic. Methods: We analyzed 97 consecutive patients from 11 March 2020 to 31 May 2020 and 52 consecutive patients from 28 August 2020 to 15 October 2020. Results: Patients belonging to the second wave were younger, had a lower number of concomitant chronic conditions (multimorbidity), and had a milder clinical phenotype. Medical treatments and respiratory support use have changed during the COVID-19 pandemic, based on different laboratory results and disease clinical features. Patients in the second wave had better short-term clinical outcomes, with lower death rates and more step-down transfers to a general ward. Conclusion: The present findings show a clear phenotypic difference in patients hospitalized at different stages of the COVID-19 pandemic in Italy. These results can help to stratify clinical risk and to better tailor medical treatments and respiratory support for patients with ARDS and COVID-19 pneumonia | ||
| 650 | 4 | |a Journal Article | |
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| 700 | 1 | |a Tummolo, Maria Grazia |e verfasserin |4 aut | |
| 700 | 1 | |a Santomasi, Carla |e verfasserin |4 aut | |
| 700 | 1 | |a Palma, Lavinia |e verfasserin |4 aut | |
| 700 | 1 | |a Fasano, Domenico |e verfasserin |4 aut | |
| 700 | 1 | |a Resta, Emanuela |e verfasserin |4 aut | |
| 700 | 1 | |a Lozupone, Madia |e verfasserin |4 aut | |
| 700 | 1 | |a Solfrizzi, Vincenzo |e verfasserin |4 aut | |
| 700 | 1 | |a Panza, Francesco |e verfasserin |4 aut | |
| 700 | 1 | |a Resta, Onofrio |e verfasserin |4 aut | |
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