Bioanalytical strategies in drug discovery and development
A reliable, rapid, and effective bioanalytical method is essential for the determination of the pharmacokinetic, pharmacodynamic, and toxicokinetic parameters that inform the safety and efficacy profile of investigational drugs. The overall goal of bioanalytical method development is to elucidate the procedure and operating conditions under which a method can sufficiently extract, qualify, and/or quantify the analyte(s) of interest and/or their metabolites for the intended purpose. Given the difference in the physicochemical properties of small and large molecule drugs, different strategies need to be adopted for the development of an effective and efficient bioanalytical method. Herein, we provide an overview of different sample preparation strategies, analytical platforms, as well as procedures for achieving high throughput for bioanalysis of small and large molecule drugs.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2021 |
|---|---|
| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:53 |
|---|---|
| Enthalten in: |
Drug metabolism reviews - 53(2021), 3 vom: 26. Aug., Seite 434-458 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Thakur, Aarzoo [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Bioanalysis |
|---|
| Anmerkungen: |
Date Completed 04.04.2022 Date Revised 31.05.2022 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1080/03602532.2021.1959606 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM328550418 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM328550418 | ||
| 003 | DE-627 | ||
| 005 | 20231225203154.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231225s2021 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1080/03602532.2021.1959606 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1095.xml |
| 035 | |a (DE-627)NLM328550418 | ||
| 035 | |a (NLM)34310243 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Thakur, Aarzoo |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Bioanalytical strategies in drug discovery and development |
| 264 | 1 | |c 2021 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 04.04.2022 | ||
| 500 | |a Date Revised 31.05.2022 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a A reliable, rapid, and effective bioanalytical method is essential for the determination of the pharmacokinetic, pharmacodynamic, and toxicokinetic parameters that inform the safety and efficacy profile of investigational drugs. The overall goal of bioanalytical method development is to elucidate the procedure and operating conditions under which a method can sufficiently extract, qualify, and/or quantify the analyte(s) of interest and/or their metabolites for the intended purpose. Given the difference in the physicochemical properties of small and large molecule drugs, different strategies need to be adopted for the development of an effective and efficient bioanalytical method. Herein, we provide an overview of different sample preparation strategies, analytical platforms, as well as procedures for achieving high throughput for bioanalysis of small and large molecule drugs | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Review | |
| 650 | 4 | |a Bioanalysis | |
| 650 | 4 | |a LC-MS/MS | |
| 650 | 4 | |a biologics | |
| 650 | 4 | |a drug discovery and development | |
| 650 | 4 | |a small molecule drugs | |
| 700 | 1 | |a Tan, Zhiyuan |e verfasserin |4 aut | |
| 700 | 1 | |a Kameyama, Tsubasa |e verfasserin |4 aut | |
| 700 | 1 | |a El-Khateeb, Eman |e verfasserin |4 aut | |
| 700 | 1 | |a Nagpal, Shakti |e verfasserin |4 aut | |
| 700 | 1 | |a Malone, Stephanie |e verfasserin |4 aut | |
| 700 | 1 | |a Jamwal, Rohitash |e verfasserin |4 aut | |
| 700 | 1 | |a Nwabufo, Chukwunonso K |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Drug metabolism reviews |d 1973 |g 53(2021), 3 vom: 26. Aug., Seite 434-458 |w (DE-627)NLM000049530 |x 1097-9883 |7 nnns |
| 773 | 1 | 8 | |g volume:53 |g year:2021 |g number:3 |g day:26 |g month:08 |g pages:434-458 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1080/03602532.2021.1959606 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 53 |j 2021 |e 3 |b 26 |c 08 |h 434-458 | ||