3-D Endoluminal Ultrasound Biomicroscopic Imaging and Volumetry of Mouse Colon Tumors
Copyright © 2021 World Federation for Ultrasound in Medicine & Biology. Published by Elsevier Inc. All rights reserved..
Currently, colonoscopy is considered the gold standard procedure for diagnosis of colorectal cancer (CRC), the third most common cancer in the United States. However, this technique fails to detect flat adenomas, serrated polyps and advanced adenomas, with miss rates of 34%, 27% and 14%, respectively. These miss rates, more frequent than previously supposed, suggest the need for new CRC screening tools. In the work described here, the potential application of a 40-MHz ultrasound system to generate a sequence of 2-D endoluminal ultrasound biomicroscopy (eUBM-2-D) images of a mouse model of colon cancer was investigated, and this image sequence was used to render eUBM-3-D images and to measure tumor volume. The technique was validated with tissue-mimicking phantoms and used in vivo with mice bearing colon polypoid tumors. Estimated volumes ranged from 0.174-7.909 mm3 for targets in validation phantoms and from 0.066-6.082 mm3 for mouse colon tumors.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:47 |
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| Enthalten in: |
Ultrasound in medicine & biology - 47(2021), 10 vom: 22. Okt., Seite 2990-3001 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
de Oliveira, Rodrigo Pereira [VerfasserIn] |
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| Links: |
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| Themen: |
3-D Imaging |
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| Anmerkungen: |
Date Completed 27.01.2022 Date Revised 27.01.2022 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.ultrasmedbio.2021.06.004 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM328497355 |
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| 520 | |a Copyright © 2021 World Federation for Ultrasound in Medicine & Biology. Published by Elsevier Inc. All rights reserved. | ||
| 520 | |a Currently, colonoscopy is considered the gold standard procedure for diagnosis of colorectal cancer (CRC), the third most common cancer in the United States. However, this technique fails to detect flat adenomas, serrated polyps and advanced adenomas, with miss rates of 34%, 27% and 14%, respectively. These miss rates, more frequent than previously supposed, suggest the need for new CRC screening tools. In the work described here, the potential application of a 40-MHz ultrasound system to generate a sequence of 2-D endoluminal ultrasound biomicroscopy (eUBM-2-D) images of a mouse model of colon cancer was investigated, and this image sequence was used to render eUBM-3-D images and to measure tumor volume. The technique was validated with tissue-mimicking phantoms and used in vivo with mice bearing colon polypoid tumors. Estimated volumes ranged from 0.174-7.909 mm3 for targets in validation phantoms and from 0.066-6.082 mm3 for mouse colon tumors | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a 3-D Imaging | |
| 650 | 4 | |a Colonic neoplasms | |
| 650 | 4 | |a Mice | |
| 650 | 4 | |a Tumor burden | |
| 650 | 4 | |a Ultrasound biomicroscopy | |
| 700 | 1 | |a Baptista, Renata Porciuncula |e verfasserin |4 aut | |
| 700 | 1 | |a Martins, Carine Belau de Castro |e verfasserin |4 aut | |
| 700 | 1 | |a Faletti, Anderson |e verfasserin |4 aut | |
| 700 | 1 | |a Soletti, Rossana Colla |e verfasserin |4 aut | |
| 700 | 1 | |a Borges, Helena Lobo |e verfasserin |4 aut | |
| 700 | 1 | |a Machado, João Carlos |e verfasserin |4 aut | |
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