LYSMD3 : A mammalian pattern recognition receptor for chitin
Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved..
Chitin, a major component of fungal cell walls, has been associated with allergic disorders such as asthma. However, it is unclear how mammals recognize chitin and the principal receptor(s) on epithelial cells that sense chitin remain to be determined. In this study, we show that LYSMD3 is expressed on the surface of human airway epithelial cells and demonstrate that LYSMD3 is able to bind chitin, as well as β-glucan, on the cell walls of fungi. Knockdown or knockout of LYSMD3 also sharply blunts the production of inflammatory cytokines by epithelial cells in response to chitin and fungal spores. Competitive inhibition of the LYSMD3 ectodomain by soluble LYSMD3 protein, multiple ligands, or antibody against LYSMD3 also blocks chitin signaling. Our study reveals LYSMD3 as a mammalian pattern recognition receptor (PRR) for chitin and establishes its role in epithelial cell inflammatory responses to chitin and fungi.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:36 |
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| Enthalten in: |
Cell reports - 36(2021), 3 vom: 20. Juli, Seite 109392 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
He, Xin [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 09.02.2022 Date Revised 29.02.2024 published: Print Citation Status MEDLINE |
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| doi: |
10.1016/j.celrep.2021.109392 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM328343870 |
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| 245 | 1 | 0 | |a LYSMD3 |b A mammalian pattern recognition receptor for chitin |
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| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved. | ||
| 520 | |a Chitin, a major component of fungal cell walls, has been associated with allergic disorders such as asthma. However, it is unclear how mammals recognize chitin and the principal receptor(s) on epithelial cells that sense chitin remain to be determined. In this study, we show that LYSMD3 is expressed on the surface of human airway epithelial cells and demonstrate that LYSMD3 is able to bind chitin, as well as β-glucan, on the cell walls of fungi. Knockdown or knockout of LYSMD3 also sharply blunts the production of inflammatory cytokines by epithelial cells in response to chitin and fungal spores. Competitive inhibition of the LYSMD3 ectodomain by soluble LYSMD3 protein, multiple ligands, or antibody against LYSMD3 also blocks chitin signaling. Our study reveals LYSMD3 as a mammalian pattern recognition receptor (PRR) for chitin and establishes its role in epithelial cell inflammatory responses to chitin and fungi | ||
| 650 | 4 | |a Journal Article | |
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| 650 | 4 | |a LYSMD3 | |
| 650 | 4 | |a allergy | |
| 650 | 4 | |a asthma | |
| 650 | 4 | |a chitin | |
| 650 | 4 | |a epithelial cell | |
| 650 | 4 | |a innate immunity | |
| 650 | 4 | |a pattern recognition receptor | |
| 650 | 4 | |a β-glucan | |
| 650 | 7 | |a beta-Glucans |2 NLM | |
| 650 | 7 | |a Chitin |2 NLM | |
| 650 | 7 | |a 1398-61-4 |2 NLM | |
| 650 | 7 | |a Membrane Proteins |2 NLM | |
| 650 | 7 | |a Receptors, Pattern Recognition |2 NLM | |
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| 700 | 1 | |a Howard, Brad A |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Yang |e verfasserin |4 aut | |
| 700 | 1 | |a Neumann, Aaron K |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Liwu |e verfasserin |4 aut | |
| 700 | 1 | |a Menon, Nidhi |e verfasserin |4 aut | |
| 700 | 1 | |a Roach, Tiffany |e verfasserin |4 aut | |
| 700 | 1 | |a Kale, Shiv D |e verfasserin |4 aut | |
| 700 | 1 | |a Samuels, David C |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Hongyan |e verfasserin |4 aut | |
| 700 | 1 | |a Kite, Trenton |e verfasserin |4 aut | |
| 700 | 1 | |a Kita, Hirohito |e verfasserin |4 aut | |
| 700 | 1 | |a Hu, Tony Y |e verfasserin |4 aut | |
| 700 | 1 | |a Luo, Mengyao |e verfasserin |4 aut | |
| 700 | 1 | |a Jones, Caroline N |e verfasserin |4 aut | |
| 700 | 1 | |a Okaa, Uju Joy |e verfasserin |4 aut | |
| 700 | 1 | |a Squillace, Diane L |e verfasserin |4 aut | |
| 700 | 1 | |a Klein, Bruce S |e verfasserin |4 aut | |
| 700 | 1 | |a Lawrence, Christopher B |e verfasserin |4 aut | |
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