The assessment of presenteeism and activity impairment in Behçet's syndrome and recurrent aphthous stomatitis : a multicentre study
© The Author(s) 2021. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For permissions, please email: journals.permissionsoup.com..
OBJECTIVE: To evaluate key factors for presenteeism and activity impairment in multinational patients with Behçet's syndrome (BS) and recurrent aphthous stomatitis (RAS).
METHODS: In this cross-sectional study, 364 BS patients from Jordan, Brazil, the United Kingdom and Turkey and 143 RAS patients from the United Kingdom and Turkey were included. The Work Productivity Activity Impairment (WPAI) scale was used for presenteeism and activity impairment. Mediation analyses were performed to evaluate both direct and indirect causal effects.
RESULTS: Presenteeism score was higher in active patients with genital ulcers and eye involvement as well as patients with comorbidities and current smokers than the others in BS (P < 0.05). In RAS, presenteeism score was elevated by oral ulcer activity in the direct path (P = 0.0073) and long disease duration as a mediator in the indirect path (P = 0.0191). Patients with active joint involvement had poor scores in absenteeism, presenteeism, overall impairment and activity impairment compared with those of inactive patients (P < 0.05). Using mediation analysis, the activity impairment score was directly mediated by joint activity (P = 0.0001) and indirectly mediated through oral ulcer-related pain in BS (P = 0.0309).
CONCLUSION: In BS, presenteeism was associated with disease activity, presence of comorbidities and being a current smoker, whereas in RAS, presenteeism was associated with oral ulcer activity and increased length of the disease. Moreover, activity impairment was adversely affected by joint activity and oral ulcer related pain in BS. Patients need to be empowered by using appropriate treatment strategies in their working environment and daily life.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:61 |
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| Enthalten in: |
Rheumatology (Oxford, England) - 61(2022), 4 vom: 11. Apr., Seite 1538-1547 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Karacayli, Umit [VerfasserIn] |
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| Links: |
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| Themen: |
Aphthous stomatitis |
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| Anmerkungen: |
Date Completed 13.04.2022 Date Revised 25.05.2022 published: Print Citation Status MEDLINE |
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| doi: |
10.1093/rheumatology/keab581 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM328340391 |
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| 100 | 1 | |a Karacayli, Umit |e verfasserin |4 aut | |
| 245 | 1 | 4 | |a The assessment of presenteeism and activity impairment in Behçet's syndrome and recurrent aphthous stomatitis |b a multicentre study |
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| 500 | |a Date Completed 13.04.2022 | ||
| 500 | |a Date Revised 25.05.2022 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © The Author(s) 2021. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For permissions, please email: journals.permissionsoup.com. | ||
| 520 | |a OBJECTIVE: To evaluate key factors for presenteeism and activity impairment in multinational patients with Behçet's syndrome (BS) and recurrent aphthous stomatitis (RAS) | ||
| 520 | |a METHODS: In this cross-sectional study, 364 BS patients from Jordan, Brazil, the United Kingdom and Turkey and 143 RAS patients from the United Kingdom and Turkey were included. The Work Productivity Activity Impairment (WPAI) scale was used for presenteeism and activity impairment. Mediation analyses were performed to evaluate both direct and indirect causal effects | ||
| 520 | |a RESULTS: Presenteeism score was higher in active patients with genital ulcers and eye involvement as well as patients with comorbidities and current smokers than the others in BS (P < 0.05). In RAS, presenteeism score was elevated by oral ulcer activity in the direct path (P = 0.0073) and long disease duration as a mediator in the indirect path (P = 0.0191). Patients with active joint involvement had poor scores in absenteeism, presenteeism, overall impairment and activity impairment compared with those of inactive patients (P < 0.05). Using mediation analysis, the activity impairment score was directly mediated by joint activity (P = 0.0001) and indirectly mediated through oral ulcer-related pain in BS (P = 0.0309) | ||
| 520 | |a CONCLUSION: In BS, presenteeism was associated with disease activity, presence of comorbidities and being a current smoker, whereas in RAS, presenteeism was associated with oral ulcer activity and increased length of the disease. Moreover, activity impairment was adversely affected by joint activity and oral ulcer related pain in BS. Patients need to be empowered by using appropriate treatment strategies in their working environment and daily life | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Multicenter Study | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Behçet’s syndrome | |
| 650 | 4 | |a aphthous stomatitis | |
| 650 | 4 | |a daily activity | |
| 650 | 4 | |a mediation analysis | |
| 650 | 4 | |a presenteeism | |
| 700 | 1 | |a Adesanya, Adebowale |e verfasserin |4 aut | |
| 700 | 1 | |a Aksoy, Aysun |e verfasserin |4 aut | |
| 700 | 1 | |a Belem, Joice M F M |e verfasserin |4 aut | |
| 700 | 1 | |a Cardin, Natália Borges |e verfasserin |4 aut | |
| 700 | 1 | |a Sarı, Fatma Busra |e verfasserin |4 aut | |
| 700 | 1 | |a Beyhan, Tuğba Emine |e verfasserin |4 aut | |
| 700 | 1 | |a Çelik, Zülal |e verfasserin |4 aut | |
| 700 | 1 | |a Karacayli, Ceren |e verfasserin |4 aut | |
| 700 | 1 | |a Alibaz-Öner, Fatma |e verfasserin |4 aut | |
| 700 | 1 | |a Inanç, Nevsun |e verfasserin |4 aut | |
| 700 | 1 | |a Ergun, Tülin |e verfasserin |4 aut | |
| 700 | 1 | |a Yay, Meral |e verfasserin |4 aut | |
| 700 | 1 | |a Madanat, Wafa |e verfasserin |4 aut | |
| 700 | 1 | |a Silva de Souza, Alexandre Wagner |e verfasserin |4 aut | |
| 700 | 1 | |a Fortune, Farida |e verfasserin |4 aut | |
| 700 | 1 | |a Direskeneli, Haner |e verfasserin |4 aut | |
| 700 | 1 | |a Mumcu, Gonca |e verfasserin |4 aut | |
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