Dissolution profiles of fenbendazole from binary solid dispersions : a mathematical approach
Aim: Understanding a drug dissolution process from solid dispersions (SD) to develop formulations with predictable in vivo performance. Materials & methods: Dissolution data of fenbendazole released from the SDs and the control physical mixtures were analyzed using the Lumped mathematical model to estimate the parameters of pharmaceutical relevance. Results: The fit data obtained by Lumped model showed that all SDs have a unique dissolution profile with an error of ±4.1% and an initial release rate 500-times higher than the pure drug, without incidence of drug/polymer ratio or polymer type. Conclusion: The Lumped model helped to understand that the main factor influencing the fenbendazole release was the type formulation (SD or physical mixture), regardless of the type or amount of polymer used.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:12 |
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| Enthalten in: |
Therapeutic delivery - 12(2021), 8 vom: 04. Aug., Seite 597-610 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Melian, María Elisa [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 02.08.2021 Date Revised 02.08.2021 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.4155/tde-2021-0014 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM328317071 |
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| 245 | 1 | 0 | |a Dissolution profiles of fenbendazole from binary solid dispersions |b a mathematical approach |
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| 500 | |a Date Revised 02.08.2021 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Aim: Understanding a drug dissolution process from solid dispersions (SD) to develop formulations with predictable in vivo performance. Materials & methods: Dissolution data of fenbendazole released from the SDs and the control physical mixtures were analyzed using the Lumped mathematical model to estimate the parameters of pharmaceutical relevance. Results: The fit data obtained by Lumped model showed that all SDs have a unique dissolution profile with an error of ±4.1% and an initial release rate 500-times higher than the pure drug, without incidence of drug/polymer ratio or polymer type. Conclusion: The Lumped model helped to understand that the main factor influencing the fenbendazole release was the type formulation (SD or physical mixture), regardless of the type or amount of polymer used | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a dissolution efficiency | |
| 650 | 4 | |a drug release | |
| 650 | 4 | |a fenbendazole | |
| 650 | 4 | |a initial release rate | |
| 650 | 4 | |a lumped model | |
| 650 | 4 | |a mathematical model | |
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| 650 | 4 | |a solid dispersions | |
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| 700 | 1 | |a Briones Nieva, Cintia Alejandra |e verfasserin |4 aut | |
| 700 | 1 | |a Domínguez, Laura |e verfasserin |4 aut | |
| 700 | 1 | |a Gonzo, Elio Emilio |e verfasserin |4 aut | |
| 700 | 1 | |a Palma, Santiago |e verfasserin |4 aut | |
| 700 | 1 | |a Bermúdez, José María |e verfasserin |4 aut | |
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