Combining Preoperative Immunoinflammatory Scores and 18F-Fluorodeoxyglucose Positron-emission Tomography Predicts Beneficiaries of Salvage Esophagectomy
Copyright © 2021 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved..
BACKGROUND: This study evaluated the prognostic value of preoperative immunoinflammatory scores and 18F-fluorodeoxyglucose positron-emission tomography (FDG-PET) for patients undergoing salvage esophagectomy to identify suitable candidates for surgery.
PATIENTS AND METHODS: Twenty-five patients undergoing salvage esophagectomy were included. The prognostic value of the preoperative C-reactive protein-to-albumin ratio (CAR), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and maximum standardized FDG uptake value (SUVmax) were investigated.
RESULTS: Multivariate analysis demonstrated high CAR to be an independent prognostic factor for overall survival (p=0.013). CAR had no association with clinicopathological variables, whereas the SUVmax was significantly positively associated with tumor aggressiveness. Multivariate analysis using residual tumor and the combination of CAR and SUVmax revealed both residual tumor (p=0.009) and high CAR/high SUVmax (p=0.016) to be independent prognostic factors for overall survival.
CONCLUSION: Preoperative evaluation of CAR as an immunoinflammatory indicator and SUVmax as a marker of tumor aggressiveness will be useful to identify suitable candidates for this high-risk surgery.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:41 |
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| Enthalten in: |
Anticancer research - 41(2021), 8 vom: 19. Aug., Seite 4005-4011 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Sakai, Makoto [VerfasserIn] |
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| Links: |
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| Themen: |
0Z5B2CJX4D |
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| Anmerkungen: |
Date Completed 28.07.2021 Date Revised 28.07.2021 published: Print Citation Status MEDLINE |
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| doi: |
10.21873/anticanres.15198 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM328271640 |
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| 245 | 1 | 0 | |a Combining Preoperative Immunoinflammatory Scores and 18F-Fluorodeoxyglucose Positron-emission Tomography Predicts Beneficiaries of Salvage Esophagectomy |
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| 500 | |a Date Revised 28.07.2021 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2021 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved. | ||
| 520 | |a BACKGROUND: This study evaluated the prognostic value of preoperative immunoinflammatory scores and 18F-fluorodeoxyglucose positron-emission tomography (FDG-PET) for patients undergoing salvage esophagectomy to identify suitable candidates for surgery | ||
| 520 | |a PATIENTS AND METHODS: Twenty-five patients undergoing salvage esophagectomy were included. The prognostic value of the preoperative C-reactive protein-to-albumin ratio (CAR), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and maximum standardized FDG uptake value (SUVmax) were investigated | ||
| 520 | |a RESULTS: Multivariate analysis demonstrated high CAR to be an independent prognostic factor for overall survival (p=0.013). CAR had no association with clinicopathological variables, whereas the SUVmax was significantly positively associated with tumor aggressiveness. Multivariate analysis using residual tumor and the combination of CAR and SUVmax revealed both residual tumor (p=0.009) and high CAR/high SUVmax (p=0.016) to be independent prognostic factors for overall survival | ||
| 520 | |a CONCLUSION: Preoperative evaluation of CAR as an immunoinflammatory indicator and SUVmax as a marker of tumor aggressiveness will be useful to identify suitable candidates for this high-risk surgery | ||
| 650 | 4 | |a Journal Article | |
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| 650 | 4 | |a Salvage esophagectomy | |
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| 700 | 1 | |a Watanabe, Takayoshi |e verfasserin |4 aut | |
| 700 | 1 | |a Saito, Hideyuki |e verfasserin |4 aut | |
| 700 | 1 | |a Ubukata, Yasunari |e verfasserin |4 aut | |
| 700 | 1 | |a Nakazawa, Nobuhiro |e verfasserin |4 aut | |
| 700 | 1 | |a Kuriyama, Kengo |e verfasserin |4 aut | |
| 700 | 1 | |a Sano, Akihiko |e verfasserin |4 aut | |
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| 700 | 1 | |a Shirabe, Ken |e verfasserin |4 aut | |
| 700 | 1 | |a Saeki, Hiroshi |e verfasserin |4 aut | |
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