Autoimmune encephalitis in a tertiary hospital in the Philippines
Copyright © 2021 Elsevier Ltd. All rights reserved..
BACKGROUND: Autoimmune encephalitis (AE) is an emerging disorder in adults and children. Due to its potentially reversible nature, prompt recognition and intervention are of utmost importance.
OBJECTIVE: To describe the clinical and paraclinical features, as well as treatment outcomes of patients with AE admitted in a Philippine tertiary hospital.
METHODS: Retrospective case series of patients with definite AE.
RESULTS: Eighteen (18) patients were included (12 adults, 6 children), majority of whom had anti-N-methyl-d-aspartate receptor (NMDAR) encephalitis. The median age of onset was 32 (IQR: 10.8) years old and 13 (IQR: 4.8) years old in the adult and pediatric population, respectively. In both age groups, most presented with psychiatric symptoms and normal imaging findings. Cerebrospinal fluid (CSF) pleocytosis was detected in 8/12 (66.7%) adults and 2/6 (33.3%) children, while CSF protein elevation was only seen in 6/12 (50%) adults. Most patients presented with seizures, and the most frequent electroencephalography (EEG) abnormality detected was slow activity (70.5%). A high proportion of patients received high dose steroids, alone (35.3%) or in combination with intravenous immunoglobulin (IVIG, 52.9%). Overall, 66.7% had improved outcomes, mostly seen in the pediatric population.
CONCLUSION: This study highlighted the broad clinical phenotype, as well as the similarities and differences of AE manifestations in adults and children. It demonstrated the limited but supportive role of laboratory investigations in the diagnosis of AE. It also underscored the importance of early intervention in AE and highlighted factors influencing treatment practices and discharge outcomes in the local setting.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2021 |
|---|---|
| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:90 |
|---|---|
| Enthalten in: |
Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia - 90(2021) vom: 20. Aug., Seite 191-198 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Reyes, Nikolai Gil D [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Autoimmune encephalitis |
|---|
| Anmerkungen: |
Date Completed 26.07.2021 Date Revised 26.07.2021 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1016/j.jocn.2021.05.052 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM328209082 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM328209082 | ||
| 003 | DE-627 | ||
| 005 | 20231225202452.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231225s2021 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.jocn.2021.05.052 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1093.xml |
| 035 | |a (DE-627)NLM328209082 | ||
| 035 | |a (NLM)34275548 | ||
| 035 | |a (PII)S0967-5868(21)00270-8 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Reyes, Nikolai Gil D |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Autoimmune encephalitis in a tertiary hospital in the Philippines |
| 264 | 1 | |c 2021 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 26.07.2021 | ||
| 500 | |a Date Revised 26.07.2021 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2021 Elsevier Ltd. All rights reserved. | ||
| 520 | |a BACKGROUND: Autoimmune encephalitis (AE) is an emerging disorder in adults and children. Due to its potentially reversible nature, prompt recognition and intervention are of utmost importance | ||
| 520 | |a OBJECTIVE: To describe the clinical and paraclinical features, as well as treatment outcomes of patients with AE admitted in a Philippine tertiary hospital | ||
| 520 | |a METHODS: Retrospective case series of patients with definite AE | ||
| 520 | |a RESULTS: Eighteen (18) patients were included (12 adults, 6 children), majority of whom had anti-N-methyl-d-aspartate receptor (NMDAR) encephalitis. The median age of onset was 32 (IQR: 10.8) years old and 13 (IQR: 4.8) years old in the adult and pediatric population, respectively. In both age groups, most presented with psychiatric symptoms and normal imaging findings. Cerebrospinal fluid (CSF) pleocytosis was detected in 8/12 (66.7%) adults and 2/6 (33.3%) children, while CSF protein elevation was only seen in 6/12 (50%) adults. Most patients presented with seizures, and the most frequent electroencephalography (EEG) abnormality detected was slow activity (70.5%). A high proportion of patients received high dose steroids, alone (35.3%) or in combination with intravenous immunoglobulin (IVIG, 52.9%). Overall, 66.7% had improved outcomes, mostly seen in the pediatric population | ||
| 520 | |a CONCLUSION: This study highlighted the broad clinical phenotype, as well as the similarities and differences of AE manifestations in adults and children. It demonstrated the limited but supportive role of laboratory investigations in the diagnosis of AE. It also underscored the importance of early intervention in AE and highlighted factors influencing treatment practices and discharge outcomes in the local setting | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Autoimmune encephalitis | |
| 650 | 4 | |a Clinical features | |
| 650 | 4 | |a Outcome | |
| 650 | 4 | |a Philippines | |
| 650 | 4 | |a Treatment | |
| 700 | 1 | |a Espiritu, Adrian I |e verfasserin |4 aut | |
| 700 | 1 | |a Agabao, Jerson F |e verfasserin |4 aut | |
| 700 | 1 | |a Abejero, Joshua Emmanuel E |e verfasserin |4 aut | |
| 700 | 1 | |a Salonga-Quimpo, Rhea Angela M |e verfasserin |4 aut | |
| 700 | 1 | |a Cabral-Lim, Leonor I |e verfasserin |4 aut | |
| 700 | 1 | |a Jamora, Roland Dominic G |e verfasserin |4 aut | |
| 700 | 1 | |a Pascual V, Jose Leonard R |e verfasserin |4 aut | |
| 700 | 1 | |a Fernandez, Marc Laurence L |e verfasserin |4 aut | |
| 700 | 1 | |a Gosiengfiao, Katerina Tanya P |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia |d 1994 |g 90(2021) vom: 20. Aug., Seite 191-198 |w (DE-627)NLM093767099 |x 1532-2653 |7 nnns |
| 773 | 1 | 8 | |g volume:90 |g year:2021 |g day:20 |g month:08 |g pages:191-198 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1016/j.jocn.2021.05.052 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 90 |j 2021 |b 20 |c 08 |h 191-198 | ||