Recent advances in cellular effects of fluoride : an update on its signalling pathway and targeted therapeutic approaches
© 2021. The Author(s), under exclusive licence to Springer Nature B.V..
Fluoride is a natural element essential in minute quantities in human's to maintain dental and skeletal health. However, the disease fluorosis manifests itself due to excessive fluoride intake mostly through drinking water and sometimes through food. At the cellular energetics level, fluoride is a known inhibitor of glycolysis. At the tissue level, the effect of fluoride has been more pronounced in the musculoskeletal systems due to its ability to retain fluoride. Fluoride alters dentinogenesis, thereby affecting the tooth enamel formation. In bones, fluoride alters the osteogenesis by replacing calcium, thus resulting in bone deformities. In skeletal muscles, high concentration and long term exposure to fluoride causes loss of muscle proteins leading to atrophy. Although fluorosis is quite a familiar problem, the exact molecular pathway is not yet clear. Extensive research on the effects of fluoride on various organs and its toxicity was reported. Indeed, it is clear that high and chronic exposure to fluoride causes cellular apoptosis. Accordingly, in this review, we have highlighted fluoride-mediated apoptosis via two vital pathways, mitochondrial-mediated and endoplasmic reticulum stress pathways. This review also elaborates on new cellular energetic, apoptotic pathways and therapeutic strategies targeted to treat fluorosis.
Medienart: |
E-Artikel |
---|
Erscheinungsjahr: |
2021 |
---|---|
Erschienen: |
2021 |
Enthalten in: |
Zur Gesamtaufnahme - volume:48 |
---|---|
Enthalten in: |
Molecular biology reports - 48(2021), 7 vom: 12. Juli, Seite 5661-5673 |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Nagendra, Apoorva H [VerfasserIn] |
---|
Links: |
---|
Anmerkungen: |
Date Completed 06.01.2022 Date Revised 06.01.2022 published: Print-Electronic Citation Status MEDLINE |
---|
doi: |
10.1007/s11033-021-06523-6 |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
NLM32799973X |
---|
LEADER | 01000naa a22002652 4500 | ||
---|---|---|---|
001 | NLM32799973X | ||
003 | DE-627 | ||
005 | 20231225202028.0 | ||
007 | cr uuu---uuuuu | ||
008 | 231225s2021 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.1007/s11033-021-06523-6 |2 doi | |
028 | 5 | 2 | |a pubmed24n1093.xml |
035 | |a (DE-627)NLM32799973X | ||
035 | |a (NLM)34254226 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 1 | |a Nagendra, Apoorva H |e verfasserin |4 aut | |
245 | 1 | 0 | |a Recent advances in cellular effects of fluoride |b an update on its signalling pathway and targeted therapeutic approaches |
264 | 1 | |c 2021 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ƒaComputermedien |b c |2 rdamedia | ||
338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
500 | |a Date Completed 06.01.2022 | ||
500 | |a Date Revised 06.01.2022 | ||
500 | |a published: Print-Electronic | ||
500 | |a Citation Status MEDLINE | ||
520 | |a © 2021. The Author(s), under exclusive licence to Springer Nature B.V. | ||
520 | |a Fluoride is a natural element essential in minute quantities in human's to maintain dental and skeletal health. However, the disease fluorosis manifests itself due to excessive fluoride intake mostly through drinking water and sometimes through food. At the cellular energetics level, fluoride is a known inhibitor of glycolysis. At the tissue level, the effect of fluoride has been more pronounced in the musculoskeletal systems due to its ability to retain fluoride. Fluoride alters dentinogenesis, thereby affecting the tooth enamel formation. In bones, fluoride alters the osteogenesis by replacing calcium, thus resulting in bone deformities. In skeletal muscles, high concentration and long term exposure to fluoride causes loss of muscle proteins leading to atrophy. Although fluorosis is quite a familiar problem, the exact molecular pathway is not yet clear. Extensive research on the effects of fluoride on various organs and its toxicity was reported. Indeed, it is clear that high and chronic exposure to fluoride causes cellular apoptosis. Accordingly, in this review, we have highlighted fluoride-mediated apoptosis via two vital pathways, mitochondrial-mediated and endoplasmic reticulum stress pathways. This review also elaborates on new cellular energetic, apoptotic pathways and therapeutic strategies targeted to treat fluorosis | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a Review | |
650 | 4 | |a Apoptosis | |
650 | 4 | |a Endoplasmic reticulum stress | |
650 | 4 | |a Fluoride | |
650 | 4 | |a Fluorosis | |
650 | 4 | |a Mitochondrial dysfunction | |
650 | 4 | |a Therapeutic approaches | |
650 | 7 | |a Antioxidants |2 NLM | |
650 | 7 | |a Biomarkers |2 NLM | |
650 | 7 | |a Oxidants |2 NLM | |
650 | 7 | |a Reactive Oxygen Species |2 NLM | |
650 | 7 | |a Fluorides |2 NLM | |
650 | 7 | |a Q80VPU408O |2 NLM | |
700 | 1 | |a Bose, Bipasha |e verfasserin |4 aut | |
700 | 1 | |a Shenoy P, Sudheer |e verfasserin |4 aut | |
773 | 0 | 8 | |i Enthalten in |t Molecular biology reports |d 1973 |g 48(2021), 7 vom: 12. Juli, Seite 5661-5673 |w (DE-627)NLM000008168 |x 1573-4978 |7 nnns |
773 | 1 | 8 | |g volume:48 |g year:2021 |g number:7 |g day:12 |g month:07 |g pages:5661-5673 |
856 | 4 | 0 | |u http://dx.doi.org/10.1007/s11033-021-06523-6 |3 Volltext |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_NLM | ||
951 | |a AR | ||
952 | |d 48 |j 2021 |e 7 |b 12 |c 07 |h 5661-5673 |