S1P signaling, its interactions and cross-talks with other partners and therapeutic importance in colorectal cancer
Copyright © 2021 Elsevier Inc. All rights reserved..
Sphingosine-1-Phosphate (S1P) plays an important role in normal physiology, inflammation, initiation and progression of cancer. Deregulation of S1P signaling causes aberrant proliferation, affects survival, leads to angiogenesis and metastasis. Sphingolipid rheostat is crucial for cellular homeostasis. Discrepancy in sphingolipid metabolism is linked to cancer and drug insensitivity. Owing to these diverse functions and being a potent mediator of tumor growth, S1P signaling might be a suitable candidate for anti-tumor therapy or combination therapy. In this review, with a focus on colorectal cancer we have summarized the interacting partners of S1P signaling pathway, its therapeutic approaches along with the contribution of S1P signaling to various cancer hallmarks.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:86 |
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| Enthalten in: |
Cellular signalling - 86(2021) vom: 20. Okt., Seite 110080 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Sattar, Real Sumayya Abdul [VerfasserIn] |
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| Links: |
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| Themen: |
26993-30-6 |
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| Anmerkungen: |
Date Completed 31.03.2022 Date Revised 01.04.2022 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.cellsig.2021.110080 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM327917067 |
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| 520 | |a Sphingosine-1-Phosphate (S1P) plays an important role in normal physiology, inflammation, initiation and progression of cancer. Deregulation of S1P signaling causes aberrant proliferation, affects survival, leads to angiogenesis and metastasis. Sphingolipid rheostat is crucial for cellular homeostasis. Discrepancy in sphingolipid metabolism is linked to cancer and drug insensitivity. Owing to these diverse functions and being a potent mediator of tumor growth, S1P signaling might be a suitable candidate for anti-tumor therapy or combination therapy. In this review, with a focus on colorectal cancer we have summarized the interacting partners of S1P signaling pathway, its therapeutic approaches along with the contribution of S1P signaling to various cancer hallmarks | ||
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| 650 | 4 | |a S1P signaling | |
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| 700 | 1 | |a Ahmad, Ejaj |e verfasserin |4 aut | |
| 700 | 1 | |a Ali, Asgar |e verfasserin |4 aut | |
| 700 | 1 | |a Mahajan, Bhawna |e verfasserin |4 aut | |
| 700 | 1 | |a Saluja, Sundeep Singh |e verfasserin |4 aut | |
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