Tocilizumab therapy in SARS-CoV-2 pneumonia : A matched retrospective cohort analysis
Copyright © 2021 Elsevier España, S.L.U. All rights reserved..
BACKGROUND: The effect of immunomodulatory therapy with tocilizumab for coronavirus disease 2019 (COVID-19) in real-life clinical practice remains controversial.
METHODS: Single-center retrospective matched cohort analysis including 47 consecutive patients treated with intravenous tocilizumab for severe COVID-19 pneumonia ("TCZ group"), matched by age, comorbidities, time from symptoms onset and baseline SpO2/FiO2 ratio with 47 patients receiving standard of care alone ("SoC group").
RESULTS: There were no significant differences between the TCZ and SoC groups in the rate of clinical improvement (hospital discharge and/or a decrease of ≥2 points on a six-point ordinal scale) by day 7 (51.1% [24/47] versus 48.9% [23/47]; P-value=1.000). No differences were observed at day 14 in terms of clinical improvement (72.3% versus 76.6%; P-value=0.791), all-cause mortality (10.6% versus 12.8%; P-value=1.000), and the composite of invasive mechanical ventilation and/or death (25.5% versus 23.4%; P-value=1.000) either. Patients in the TCZ group had a more rapid normalization of C-reactive protein levels.
CONCLUSIONS: No apparent benefit was observed in patients with severe COVID-19 treated with tocilizumab as compared to a matched retrospective cohort.
Medienart: |
E-Artikel |
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Erscheinungsjahr: |
2022 |
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Erschienen: |
2022 |
Enthalten in: |
Zur Gesamtaufnahme - volume:158 |
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Enthalten in: |
Medicina clinica - 158(2022), 12 vom: 24. Juni, Seite 608-612 |
Sprache: |
Englisch |
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Beteiligte Personen: |
Fernández-Ruiz, Mario [VerfasserIn] |
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Links: |
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Themen: |
Antibodies, Monoclonal, Humanized |
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Anmerkungen: |
Date Completed 21.06.2022 Date Revised 17.12.2022 published: Print-Electronic Citation Status MEDLINE |
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doi: |
10.1016/j.medcli.2021.06.014 |
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funding: |
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Förderinstitution / Projekttitel: |
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PPN (Katalog-ID): |
NLM327898267 |
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520 | |a Copyright © 2021 Elsevier España, S.L.U. All rights reserved. | ||
520 | |a BACKGROUND: The effect of immunomodulatory therapy with tocilizumab for coronavirus disease 2019 (COVID-19) in real-life clinical practice remains controversial | ||
520 | |a METHODS: Single-center retrospective matched cohort analysis including 47 consecutive patients treated with intravenous tocilizumab for severe COVID-19 pneumonia ("TCZ group"), matched by age, comorbidities, time from symptoms onset and baseline SpO2/FiO2 ratio with 47 patients receiving standard of care alone ("SoC group") | ||
520 | |a RESULTS: There were no significant differences between the TCZ and SoC groups in the rate of clinical improvement (hospital discharge and/or a decrease of ≥2 points on a six-point ordinal scale) by day 7 (51.1% [24/47] versus 48.9% [23/47]; P-value=1.000). No differences were observed at day 14 in terms of clinical improvement (72.3% versus 76.6%; P-value=0.791), all-cause mortality (10.6% versus 12.8%; P-value=1.000), and the composite of invasive mechanical ventilation and/or death (25.5% versus 23.4%; P-value=1.000) either. Patients in the TCZ group had a more rapid normalization of C-reactive protein levels | ||
520 | |a CONCLUSIONS: No apparent benefit was observed in patients with severe COVID-19 treated with tocilizumab as compared to a matched retrospective cohort | ||
650 | 4 | |a Case Reports | |
650 | 4 | |a COVID-19 | |
650 | 4 | |a Estudio de cohortes pareadas | |
650 | 4 | |a Evolución | |
650 | 4 | |a Immunomodulatory therapy | |
650 | 4 | |a Matched cohort study | |
650 | 4 | |a Outcome | |
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700 | 1 | |a Aguado, José María |e verfasserin |4 aut | |
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