A cortical injury model in a non-human primate to assess execution of reach and grasp actions : implications for recovery after traumatic brain injury
Copyright © 2021 Elsevier B.V. All rights reserved..
BACKGROUND: Technological advances in developing experimentally controlled models of traumatic brain injury (TBI) are prevalent in rodent models and these models have proven invaluable in characterizing temporal changes in brain and behavior after trauma. To date no long-term studies in non-human primates (NHPs) have been published using an experimentally controlled impact device to follow behavioral performance over time.
NEW METHOD: We have employed a controlled cortical impact (CCI) device to create a focal contusion to the hand area in primary motor cortex (M1) of three New World monkeys to characterize changes in reach and grasp function assessed for 3 months after the injury.
RESULTS: The CCI destroyed most of M1 hand representation reducing grey matter by 9.6 mm3, 12.9 mm3, and 15.5 mm3 and underlying corona radiata by 7.4 mm3, 6.9 mm3, and 5.6 mm3 respectively. Impaired motor function was confined to the hand contralateral to the injury. Gross hand-use was only mildly affected during the first few days of observation after injury while activity requiring skilled use of the hand was impaired over three months.
COMPARISON WITH EXISTING METHOD(S): This study is unique in establishing a CCI model of TBI in an NHP resulting in persistent impairments in motor function evident in volitional use of the hand.
CONCLUSIONS: Establishing an NHP model of TBI is essential to extend current rodent models to the complex neural architecture of the primate brain. Moving forward this model can be used to investigate novel therapeutic interventions to improve or restore impaired motor function after trauma.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:361 |
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| Enthalten in: |
Journal of neuroscience methods - 361(2021) vom: 01. Sept., Seite 109283 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Barbay, Scott [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 23.08.2021 Date Revised 01.03.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.jneumeth.2021.109283 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
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| 100 | 1 | |a Barbay, Scott |e verfasserin |4 aut | |
| 245 | 1 | 2 | |a A cortical injury model in a non-human primate to assess execution of reach and grasp actions |b implications for recovery after traumatic brain injury |
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| 500 | |a Date Revised 01.03.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2021 Elsevier B.V. All rights reserved. | ||
| 520 | |a BACKGROUND: Technological advances in developing experimentally controlled models of traumatic brain injury (TBI) are prevalent in rodent models and these models have proven invaluable in characterizing temporal changes in brain and behavior after trauma. To date no long-term studies in non-human primates (NHPs) have been published using an experimentally controlled impact device to follow behavioral performance over time | ||
| 520 | |a NEW METHOD: We have employed a controlled cortical impact (CCI) device to create a focal contusion to the hand area in primary motor cortex (M1) of three New World monkeys to characterize changes in reach and grasp function assessed for 3 months after the injury | ||
| 520 | |a RESULTS: The CCI destroyed most of M1 hand representation reducing grey matter by 9.6 mm3, 12.9 mm3, and 15.5 mm3 and underlying corona radiata by 7.4 mm3, 6.9 mm3, and 5.6 mm3 respectively. Impaired motor function was confined to the hand contralateral to the injury. Gross hand-use was only mildly affected during the first few days of observation after injury while activity requiring skilled use of the hand was impaired over three months | ||
| 520 | |a COMPARISON WITH EXISTING METHOD(S): This study is unique in establishing a CCI model of TBI in an NHP resulting in persistent impairments in motor function evident in volitional use of the hand | ||
| 520 | |a CONCLUSIONS: Establishing an NHP model of TBI is essential to extend current rodent models to the complex neural architecture of the primate brain. Moving forward this model can be used to investigate novel therapeutic interventions to improve or restore impaired motor function after trauma | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, N.I.H., Extramural | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Research Support, U.S. Gov't, Non-P.H.S. | |
| 650 | 4 | |a Brain injury | |
| 650 | 4 | |a Controlled cortical impact | |
| 650 | 4 | |a Hand | |
| 650 | 4 | |a Motor cortex | |
| 650 | 4 | |a Recovery of function | |
| 650 | 4 | |a Tbi | |
| 700 | 1 | |a Zhang, Hongyu |e verfasserin |4 aut | |
| 700 | 1 | |a Frost, Shawn B |e verfasserin |4 aut | |
| 700 | 1 | |a Peterson, Jeremy C |e verfasserin |4 aut | |
| 700 | 1 | |a Guggenmos, David J |e verfasserin |4 aut | |
| 700 | 1 | |a Hudson, Heather M |e verfasserin |4 aut | |
| 700 | 1 | |a Bundy, David T |e verfasserin |4 aut | |
| 700 | 1 | |a DeJong, Stacey L |e verfasserin |4 aut | |
| 700 | 1 | |a Nudo, Randolph J |e verfasserin |4 aut | |
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