Angiotensin-converting enzyme 2 gene expression in human male urological tissues : implications for pathogenesis and virus transmission pathways
© The Author(s) 2021..
BACKGROUND: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection occurs through binding and internalization of the viral spike protein to the angiotensin-converting enzyme 2 (ACE2) receptor on the host cell membrane. Pathological changes are caused by damage and failure of vital organs that express high levels of ACE2, including the lungs, the heart and the kidneys. The aim of this study was to investigate ACE2 gene expression in the human male urogenital tract using a public database.
METHODS: A search of transcriptomic datasets from a database to investigate ACE2 gene expression in human urogenital tract tissue.
RESULTS: The gene expression profile demonstrated that ACE2 gene expression was higher in human kidney cortex and testis than human lung tissue. The gene expression profile demonstrated that ACE2 gene expression in the human bladder and prostate was comparable to human lung tissue.
CONCLUSIONS: Male urogenital tissues are directly susceptible to SARS-CoV-2 infection through the expression of ACE2. Moreover, the SARS-Cov-2/ACE2 interaction may disturb the male genital and reproductive functions.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:27 |
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| Enthalten in: |
African journal of urology : the official journal of the Pan African Urological Surgeons' Association (PAUSA) - 27(2021), 1 vom: 01., Seite 89 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Al-Benna, Sammy [VerfasserIn] |
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| Links: |
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| Themen: |
Angiotensin-converting enzyme 2 receptor |
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| Anmerkungen: |
Date Revised 20.09.2023 published: Print-Electronic Citation Status PubMed-not-MEDLINE |
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| doi: |
10.1186/s12301-021-00192-4 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM327768967 |
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| 100 | 1 | |a Al-Benna, Sammy |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Angiotensin-converting enzyme 2 gene expression in human male urological tissues |b implications for pathogenesis and virus transmission pathways |
| 264 | 1 | |c 2021 | |
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| 500 | |a Date Revised 20.09.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a © The Author(s) 2021. | ||
| 520 | |a BACKGROUND: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection occurs through binding and internalization of the viral spike protein to the angiotensin-converting enzyme 2 (ACE2) receptor on the host cell membrane. Pathological changes are caused by damage and failure of vital organs that express high levels of ACE2, including the lungs, the heart and the kidneys. The aim of this study was to investigate ACE2 gene expression in the human male urogenital tract using a public database | ||
| 520 | |a METHODS: A search of transcriptomic datasets from a database to investigate ACE2 gene expression in human urogenital tract tissue | ||
| 520 | |a RESULTS: The gene expression profile demonstrated that ACE2 gene expression was higher in human kidney cortex and testis than human lung tissue. The gene expression profile demonstrated that ACE2 gene expression in the human bladder and prostate was comparable to human lung tissue | ||
| 520 | |a CONCLUSIONS: Male urogenital tissues are directly susceptible to SARS-CoV-2 infection through the expression of ACE2. Moreover, the SARS-Cov-2/ACE2 interaction may disturb the male genital and reproductive functions | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Angiotensin-converting enzyme 2 receptor | |
| 650 | 4 | |a COVID-19 | |
| 650 | 4 | |a Coronavirus | |
| 650 | 4 | |a Fertility | |
| 650 | 4 | |a Genitalia | |
| 650 | 4 | |a Male | |
| 650 | 4 | |a Severe acute respiratory syndrome coronavirus 2 | |
| 650 | 4 | |a Urology | |
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