Therapeutic outcome of diverticular associated colitis - a retrospective single centre experience
© Acta Gastro-Enterologica Belgica..
BACKGROUND: Diverticular associated colitis (DAC) has become increasingly appreciated as a form of inflammatory disease, localized mainly in the sigmoid, and defined as chronic inflammation of the interdiverticular mucosa with sparing of rectum, right colon and diverticula themselves.
METHODS: A retrospective case identification from January 2005 to December 2016 was performed. Patients with a diagnosis of DAC based on clinical, endoscopic and histological findings were enrolled. We analyzed their characteristics and response to therapy, and performed a review of literature.
RESULTS: Out of 377 pathology reports, 37 cases of DAC were identified, with a median age of 73 years and followed during 1-13 years. Six patients (16.22%) were refractory to conservative treatment and required surgery. In three patients (8.11%) evolution to ulcerative colitis (UC) was observed. Patients were divided into four endoscopic patterns, with a more benign course for type A "crescentic fold disease" compared to the other subtypes. Patients with type B "mild to moderate ulcerative colitis-like" were at significantly higher risk of persistent disease activity or relapse (p < 0.01).
CONCLUSION: DAC is a multifaceted disease and considered to be a relatively benign condition. However, a subset of patients requires surgery and/or may progress to develop UC.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:84 |
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| Enthalten in: |
Acta gastro-enterologica Belgica - 84(2021), 2 vom: 13. Apr., Seite 275-281 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Vulsteke, F [VerfasserIn] |
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| Links: |
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| Themen: |
Diverticulosis |
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| Anmerkungen: |
Date Completed 06.07.2021 Date Revised 24.04.2022 published: Print Citation Status MEDLINE |
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| doi: |
10.51821/84.2.275 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM327638400 |
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| 520 | |a © Acta Gastro-Enterologica Belgica. | ||
| 520 | |a BACKGROUND: Diverticular associated colitis (DAC) has become increasingly appreciated as a form of inflammatory disease, localized mainly in the sigmoid, and defined as chronic inflammation of the interdiverticular mucosa with sparing of rectum, right colon and diverticula themselves | ||
| 520 | |a METHODS: A retrospective case identification from January 2005 to December 2016 was performed. Patients with a diagnosis of DAC based on clinical, endoscopic and histological findings were enrolled. We analyzed their characteristics and response to therapy, and performed a review of literature | ||
| 520 | |a RESULTS: Out of 377 pathology reports, 37 cases of DAC were identified, with a median age of 73 years and followed during 1-13 years. Six patients (16.22%) were refractory to conservative treatment and required surgery. In three patients (8.11%) evolution to ulcerative colitis (UC) was observed. Patients were divided into four endoscopic patterns, with a more benign course for type A "crescentic fold disease" compared to the other subtypes. Patients with type B "mild to moderate ulcerative colitis-like" were at significantly higher risk of persistent disease activity or relapse (p < 0.01) | ||
| 520 | |a CONCLUSION: DAC is a multifaceted disease and considered to be a relatively benign condition. However, a subset of patients requires surgery and/or may progress to develop UC | ||
| 650 | 4 | |a Journal Article | |
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| 650 | 4 | |a diverticulosis | |
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| 650 | 4 | |a segmental colitis | |
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