Membrane-Associated Flavivirus Replication Complex-Its Organization and Regulation
Flavivirus consists of a large number of arthropod-borne viruses, many of which cause life-threatening diseases in humans. A characteristic feature of flavivirus infection is to induce the rearrangement of intracellular membrane structure in the cytoplasm. This unique membranous structure called replication organelle is considered as a microenvironment that provides factors required for the activity of the flaviviral replication complex. The replication organelle serves as a place to coordinate viral RNA amplification, protein translation, and virion assembly and also to protect the viral replication complex from the cellular immune defense system. In this review, we summarize the current understanding of how the formation and function of membrane-associated flaviviral replication organelle are regulated by cellular factors.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:13 |
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| Enthalten in: |
Viruses - 13(2021), 6 vom: 03. Juni |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Morita, Eiji [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 08.12.2021 Date Revised 14.12.2021 published: Electronic Citation Status MEDLINE |
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| doi: |
10.3390/v13061060 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM327517786 |
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| 520 | |a Flavivirus consists of a large number of arthropod-borne viruses, many of which cause life-threatening diseases in humans. A characteristic feature of flavivirus infection is to induce the rearrangement of intracellular membrane structure in the cytoplasm. This unique membranous structure called replication organelle is considered as a microenvironment that provides factors required for the activity of the flaviviral replication complex. The replication organelle serves as a place to coordinate viral RNA amplification, protein translation, and virion assembly and also to protect the viral replication complex from the cellular immune defense system. In this review, we summarize the current understanding of how the formation and function of membrane-associated flaviviral replication organelle are regulated by cellular factors | ||
| 650 | 4 | |a Journal Article | |
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| 650 | 4 | |a Review | |
| 650 | 4 | |a cellular factors | |
| 650 | 4 | |a endoplasmic reticulum | |
| 650 | 4 | |a flavivirus | |
| 650 | 4 | |a interferon-stimulated genes | |
| 650 | 4 | |a membranous microenvironment | |
| 650 | 4 | |a replication complex | |
| 650 | 4 | |a replication organelle | |
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| 650 | 7 | |a Viral Nonstructural Proteins |2 NLM | |
| 700 | 1 | |a Suzuki, Youichi |e verfasserin |4 aut | |
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