Measles Sclerosing Subacute PanEncephalitis (SSPE), an intriguing and ever-present disease : Data, assumptions and new perspectives
Copyright © 2021. Published by Elsevier Masson SAS..
BACKGROUND: Subacute sclerosing panencephalitis (SSPE) is a rare, non-treatable and fatal neurological complication of measles, still present due to the return of the epidemic linked to the loosening of vaccination policies. Its mechanism remains unexplained.
OBJECTIVE: The main objective was to investigate explanatory variables relating to the risk of developing SSPE and its pathophysiology.
METHODS: Literature analysis was focused on different varieties of SSPE: perinatal forms, short-incubation forms similar to acute measles inclusion body encephalitis (MIBE), rapidly evolving forms, forms occurring in the immunosuppressed, adult forms, and family forms. In addition, several studies on the parameters of innate immunity and interferon responses of patients were analyzed.
RESULTS: Two main data were highlighted: a relationship between the so-called fulminant forms and the prescription of corticosteroids was established. In familial SSPE, two groups were individualized according to the duration of the latency period, prompting an analysis of patient exomes.
CONCLUSION: Treatment with corticosteroids should be banned. Knowledge of the genes involved and epigenetics should be useful for understanding the pathophysiology of SSPE and other late-onset neurological infections with RNA viruses.
| Errataetall: |
ErratumIn: Rev Neurol (Paris). 2022 Jun;178(6):634. - PMID 35610097 |
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:177 |
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| Enthalten in: |
Revue neurologique - 177(2021), 9 vom: 26. Nov., Seite 1059-1068 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Lebon, P [VerfasserIn] |
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| Links: |
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| Themen: |
COVID-19 |
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| Anmerkungen: |
Date Completed 16.11.2021 Date Revised 24.05.2022 published: Print-Electronic ErratumIn: Rev Neurol (Paris). 2022 Jun;178(6):634. - PMID 35610097 Citation Status MEDLINE |
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| doi: |
10.1016/j.neurol.2021.02.387 |
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| 500 | |a Date Revised 24.05.2022 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a ErratumIn: Rev Neurol (Paris). 2022 Jun;178(6):634. - PMID 35610097 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2021. Published by Elsevier Masson SAS. | ||
| 520 | |a BACKGROUND: Subacute sclerosing panencephalitis (SSPE) is a rare, non-treatable and fatal neurological complication of measles, still present due to the return of the epidemic linked to the loosening of vaccination policies. Its mechanism remains unexplained | ||
| 520 | |a OBJECTIVE: The main objective was to investigate explanatory variables relating to the risk of developing SSPE and its pathophysiology | ||
| 520 | |a METHODS: Literature analysis was focused on different varieties of SSPE: perinatal forms, short-incubation forms similar to acute measles inclusion body encephalitis (MIBE), rapidly evolving forms, forms occurring in the immunosuppressed, adult forms, and family forms. In addition, several studies on the parameters of innate immunity and interferon responses of patients were analyzed | ||
| 520 | |a RESULTS: Two main data were highlighted: a relationship between the so-called fulminant forms and the prescription of corticosteroids was established. In familial SSPE, two groups were individualized according to the duration of the latency period, prompting an analysis of patient exomes | ||
| 520 | |a CONCLUSION: Treatment with corticosteroids should be banned. Knowledge of the genes involved and epigenetics should be useful for understanding the pathophysiology of SSPE and other late-onset neurological infections with RNA viruses | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Review | |
| 650 | 4 | |a COVID-19 | |
| 650 | 4 | |a Genes | |
| 650 | 4 | |a Interferon | |
| 650 | 4 | |a Measles virus | |
| 650 | 4 | |a Subacute encephalitis | |
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| 700 | 1 | |a Zhang, S-Y |e verfasserin |4 aut | |
| 700 | 1 | |a Casanova, J-L |e verfasserin |4 aut | |
| 700 | 1 | |a Hauw, J-J |e verfasserin |4 aut | |
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