Influence of early biliary complications on survival rates after pediatric liver transplantation-A positive outlook
© 2021 The Authors. Pediatric Transplantation published by Wiley Periodicals LLC..
BACKGROUND: Early biliary complications (EBC) constitute a burden after pediatric liver transplantation frequently requiring immediate therapy. We aimed to assess the impact of EBC on short- and long-term patient and graft survival as well as post-transplant morbidity.
METHODS: We analyzed 121 pediatric liver transplantations performed between 1984 and 2019 at the Medical University of Innsbruck for the occurrence of early (<90 days) biliary complications and investigated the influence of EBC on patient and graft survival.
RESULTS: Early biliary complications occurred in 30 (24.8%) out of the 121 pediatric liver transplant recipients. Patient survival at 15 years (89.2% vs. 84.2%, p = .65) and all-cause (82.5% vs. 74.0%) and death-censored graft survival (82.5% vs. 75.1%, p = .71) at 10 years were similar between the EBC and the non-EBC group. The EBC group had a significantly longer ICU (25 vs. 16 days, p < .001) and initial hospital stay (64 vs. 42 days, p = .002). Livers of patients with EBC were characterized by multiple bile ducts (33.3% vs. 13.2%, p = .027), and patients with EBC had a higher risk to develop late biliary complications (OR 2.821 [95% CI 1.049-7.587], p = .044) and bowel obstruction/perforation (OR 4.388 [95% CI 1.503-12.812], p = .007).
CONCLUSION: Early biliary complications after pediatric liver transplantation is frequent. The occurrence of EBC significantly increased post-transplant morbidity without affecting mortality. Multiple bile ducts were the only risk factor for the development of EBC in our cohort.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:25 |
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| Enthalten in: |
Pediatric transplantation - 25(2021), 7 vom: 07. Nov., Seite e14075 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Berchtold, Valeria [VerfasserIn] |
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| Links: |
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| Themen: |
Early biliary complications |
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| Anmerkungen: |
Date Completed 02.02.2022 Date Revised 02.02.2022 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1111/petr.14075 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM327323329 |
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| 520 | |a © 2021 The Authors. Pediatric Transplantation published by Wiley Periodicals LLC. | ||
| 520 | |a BACKGROUND: Early biliary complications (EBC) constitute a burden after pediatric liver transplantation frequently requiring immediate therapy. We aimed to assess the impact of EBC on short- and long-term patient and graft survival as well as post-transplant morbidity | ||
| 520 | |a METHODS: We analyzed 121 pediatric liver transplantations performed between 1984 and 2019 at the Medical University of Innsbruck for the occurrence of early (<90 days) biliary complications and investigated the influence of EBC on patient and graft survival | ||
| 520 | |a RESULTS: Early biliary complications occurred in 30 (24.8%) out of the 121 pediatric liver transplant recipients. Patient survival at 15 years (89.2% vs. 84.2%, p = .65) and all-cause (82.5% vs. 74.0%) and death-censored graft survival (82.5% vs. 75.1%, p = .71) at 10 years were similar between the EBC and the non-EBC group. The EBC group had a significantly longer ICU (25 vs. 16 days, p < .001) and initial hospital stay (64 vs. 42 days, p = .002). Livers of patients with EBC were characterized by multiple bile ducts (33.3% vs. 13.2%, p = .027), and patients with EBC had a higher risk to develop late biliary complications (OR 2.821 [95% CI 1.049-7.587], p = .044) and bowel obstruction/perforation (OR 4.388 [95% CI 1.503-12.812], p = .007) | ||
| 520 | |a CONCLUSION: Early biliary complications after pediatric liver transplantation is frequent. The occurrence of EBC significantly increased post-transplant morbidity without affecting mortality. Multiple bile ducts were the only risk factor for the development of EBC in our cohort | ||
| 650 | 4 | |a Journal Article | |
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| 700 | 1 | |a Messner, Franka |e verfasserin |4 aut | |
| 700 | 1 | |a Weissenbacher, Annemarie |e verfasserin |4 aut | |
| 700 | 1 | |a Oberhuber, Rupert |e verfasserin |4 aut | |
| 700 | 1 | |a Entenmann, Andreas |e verfasserin |4 aut | |
| 700 | 1 | |a Aldrian, Denise |e verfasserin |4 aut | |
| 700 | 1 | |a Vogel, Georg |e verfasserin |4 aut | |
| 700 | 1 | |a Margreiter, Christian |e verfasserin |4 aut | |
| 700 | 1 | |a Ulmer, Hanno |e verfasserin |4 aut | |
| 700 | 1 | |a Krapf, Johanna |e verfasserin |4 aut | |
| 700 | 1 | |a Cardini, Benno |e verfasserin |4 aut | |
| 700 | 1 | |a Schlitt, Hans J |e verfasserin |4 aut | |
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| 700 | 1 | |a Müller, Thomas |e verfasserin |4 aut | |
| 700 | 1 | |a Schneeberger, Stefan |e verfasserin |4 aut | |
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