Phosphatidylserine Receptors Enhance SARS-CoV-2 Infection : AXL as a Therapeutic Target for COVID-19
Phosphatidylserine (PS) receptors are PS binding proteins that mediate uptake of apoptotic bodies. Many enveloped viruses utilize this PS/PS receptor mechanism to adhere to and internalize into the endosomal compartment of cells and this is termed apoptotic mimicry. For viruses that have a mechanism(s) of endosomal escape, apoptotic mimicry is a productive route of virus entry. We evaluated if PS receptors serve as cell surface receptors for SARS-CoV-2 and found that the PS receptors, AXL, TIM-1 and TIM-4, facilitated virus infection when low concentrations of the SARS-CoV-2 cognate receptor, ACE2, was present. Consistent with the established mechanism of PS receptor utilization by other viruses, PS liposomes competed with SARS-CoV-2 for binding and entry. We demonstrated that this PS receptor enhances SARS-CoV-2 binding to and infection of an array of human lung cell lines and is an under-appreciated but potentially important host factor facilitating SARS-CoV-2 entry.
| Errataetall: |
UpdateIn: PLoS Pathog. 2021 Nov 19;17(11):e1009743. - PMID 34797899 |
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - year:2021 |
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| Enthalten in: |
bioRxiv : the preprint server for biology - (2021) vom: 24. Juni |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Bohan, Dana [VerfasserIn] |
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| Links: |
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| Themen: |
ACE2 |
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| Anmerkungen: |
Date Revised 14.01.2022 published: Electronic UpdateIn: PLoS Pathog. 2021 Nov 19;17(11):e1009743. - PMID 34797899 Citation Status PubMed-not-MEDLINE |
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| doi: |
10.1101/2021.06.15.448419 |
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| funding: |
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| PPN (Katalog-ID): |
NLM327066598 |
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| 520 | |a Phosphatidylserine (PS) receptors are PS binding proteins that mediate uptake of apoptotic bodies. Many enveloped viruses utilize this PS/PS receptor mechanism to adhere to and internalize into the endosomal compartment of cells and this is termed apoptotic mimicry. For viruses that have a mechanism(s) of endosomal escape, apoptotic mimicry is a productive route of virus entry. We evaluated if PS receptors serve as cell surface receptors for SARS-CoV-2 and found that the PS receptors, AXL, TIM-1 and TIM-4, facilitated virus infection when low concentrations of the SARS-CoV-2 cognate receptor, ACE2, was present. Consistent with the established mechanism of PS receptor utilization by other viruses, PS liposomes competed with SARS-CoV-2 for binding and entry. We demonstrated that this PS receptor enhances SARS-CoV-2 binding to and infection of an array of human lung cell lines and is an under-appreciated but potentially important host factor facilitating SARS-CoV-2 entry | ||
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| 700 | 1 | |a Ert, Hanora Van |e verfasserin |4 aut | |
| 700 | 1 | |a Ruggio, Natalie |e verfasserin |4 aut | |
| 700 | 1 | |a Rogers, Kai J |e verfasserin |4 aut | |
| 700 | 1 | |a Badreddine, Mohammad |e verfasserin |4 aut | |
| 700 | 1 | |a Aguilar Briseño, José A |e verfasserin |4 aut | |
| 700 | 1 | |a Rojas Chavez, Roberth Anthony |e verfasserin |4 aut | |
| 700 | 1 | |a Gao, Boning |e verfasserin |4 aut | |
| 700 | 1 | |a Stokowy, Tomasz |e verfasserin |4 aut | |
| 700 | 1 | |a Christakou, Eleni |e verfasserin |4 aut | |
| 700 | 1 | |a Micklem, David |e verfasserin |4 aut | |
| 700 | 1 | |a Gausdal, Gro |e verfasserin |4 aut | |
| 700 | 1 | |a Haim, Hillel |e verfasserin |4 aut | |
| 700 | 1 | |a Minna, John |e verfasserin |4 aut | |
| 700 | 1 | |a Lorens, James B |e verfasserin |4 aut | |
| 700 | 1 | |a Maury, Wendy |e verfasserin |4 aut | |
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