Impact of frailty metabolic phenotypes on the management of older people with type 2 diabetes mellitus
© 2021 Japan Geriatrics Society..
AIMS: To provide a pathophysiological basis for distinguishing metabolic variants of the frailty phenotype in older adults with type 2 diabetes.
METHODS: We have made an in-depth review of the possible mechanisms in diabetes, ageing and frailty that will alter allow us to describe phenotypic changes which might assist in predicting responses to particular glucose-lowering therapy.
RESULTS: Our review has enable us to describe with some confidence a sarcopenic obese phenotype and an anorexic malnourished phenotype.
CONCLUSIONS: By identifying these two phenotypes we can predict which would be most responsive to certain classes of therapy and where therapies may be ill-advised. This represents the first novel approach in this area. Further work is being planned to develop this hypothesis. Geriatr Gerontol Int 2021; 21: 614-622.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:21 |
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| Enthalten in: |
Geriatrics & gerontology international - 21(2021), 8 vom: 15. Aug., Seite 614-622 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Abdelhafiz, Ahmed H [VerfasserIn] |
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| Links: |
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| Themen: |
Diabetes |
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| Anmerkungen: |
Date Completed 18.08.2021 Date Revised 18.08.2021 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1111/ggi.14214 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM326989420 |
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| 500 | |a Date Revised 18.08.2021 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2021 Japan Geriatrics Society. | ||
| 520 | |a AIMS: To provide a pathophysiological basis for distinguishing metabolic variants of the frailty phenotype in older adults with type 2 diabetes | ||
| 520 | |a METHODS: We have made an in-depth review of the possible mechanisms in diabetes, ageing and frailty that will alter allow us to describe phenotypic changes which might assist in predicting responses to particular glucose-lowering therapy | ||
| 520 | |a RESULTS: Our review has enable us to describe with some confidence a sarcopenic obese phenotype and an anorexic malnourished phenotype | ||
| 520 | |a CONCLUSIONS: By identifying these two phenotypes we can predict which would be most responsive to certain classes of therapy and where therapies may be ill-advised. This represents the first novel approach in this area. Further work is being planned to develop this hypothesis. Geriatr Gerontol Int 2021; 21: 614-622 | ||
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| 650 | 4 | |a management | |
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| 700 | 1 | |a Sinclair, Alan J |e verfasserin |4 aut | |
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