Benzodiazepines and Sleep Architecture : A Systematic Review
Copyright© Bentham Science Publishers; For any queries, please email at epubbenthamscience.net..
BACKGROUND: Insomnia, defined as a difficulty in initiating or maintaining sleep, is a relevant medical issue. Benzodiazepines (BZDs) are commonly prescribed to treat insomnia. Two phases characterize human sleep structure: sleep with Non-Rapid Eye Movement (NREM) and sleep with Rapid Eye Movement (REM). Physiological sleep includes NREM and REM phases in a continuous cycle known as "Sleep Architecture.".
OBJECTIVE: This systematic review summarizes the studies that have investigated effects of BZDs on Sleep Architecture.
METHODS: The articles selection included human clinical trials (in English, Portuguese, or Spanish) only, specifically focused on BZDs effects on sleep architecture. PubMed, BVS, and Google Scholar databases were searched.
RESULTS: Findings on BZDs effects on sleep architecture confirm an increase in stage 2 of NREM sleep and a decrease in time of stages 3 and 4 of NREM sleep with a reduction in time of REM sleep during the nocturnal sleep.
CONCLUSION: Variations in NREM and REM sleep may lead to deficits in concentration and working memory and weight gain. The increase in stage 2 of NREM sleep may lead to a subjective improvement of sleep quality with no awakenings. BZDz should be prescribed with zeal and professional judgment. These patients should be closely monitored for possible long-term side effects.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2023 |
|---|---|
| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:22 |
|---|---|
| Enthalten in: |
CNS & neurological disorders drug targets - 22(2023), 2 vom: 05., Seite 172-179 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
de Mendonça, Felipe Maraucci Ribeiro [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
12794-10-4 |
|---|
| Anmerkungen: |
Date Completed 15.12.2022 Date Revised 21.03.2023 published: Print Citation Status MEDLINE |
|---|
| doi: |
10.2174/1871527320666210618103344 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM326934707 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM326934707 | ||
| 003 | DE-627 | ||
| 005 | 20231225195649.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231225s2023 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.2174/1871527320666210618103344 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1089.xml |
| 035 | |a (DE-627)NLM326934707 | ||
| 035 | |a (NLM)34145997 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a de Mendonça, Felipe Maraucci Ribeiro |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Benzodiazepines and Sleep Architecture |b A Systematic Review |
| 264 | 1 | |c 2023 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 15.12.2022 | ||
| 500 | |a Date Revised 21.03.2023 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright© Bentham Science Publishers; For any queries, please email at epubbenthamscience.net. | ||
| 520 | |a BACKGROUND: Insomnia, defined as a difficulty in initiating or maintaining sleep, is a relevant medical issue. Benzodiazepines (BZDs) are commonly prescribed to treat insomnia. Two phases characterize human sleep structure: sleep with Non-Rapid Eye Movement (NREM) and sleep with Rapid Eye Movement (REM). Physiological sleep includes NREM and REM phases in a continuous cycle known as "Sleep Architecture." | ||
| 520 | |a OBJECTIVE: This systematic review summarizes the studies that have investigated effects of BZDs on Sleep Architecture | ||
| 520 | |a METHODS: The articles selection included human clinical trials (in English, Portuguese, or Spanish) only, specifically focused on BZDs effects on sleep architecture. PubMed, BVS, and Google Scholar databases were searched | ||
| 520 | |a RESULTS: Findings on BZDs effects on sleep architecture confirm an increase in stage 2 of NREM sleep and a decrease in time of stages 3 and 4 of NREM sleep with a reduction in time of REM sleep during the nocturnal sleep | ||
| 520 | |a CONCLUSION: Variations in NREM and REM sleep may lead to deficits in concentration and working memory and weight gain. The increase in stage 2 of NREM sleep may lead to a subjective improvement of sleep quality with no awakenings. BZDz should be prescribed with zeal and professional judgment. These patients should be closely monitored for possible long-term side effects | ||
| 650 | 4 | |a Systematic Review | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Benzodiazepines | |
| 650 | 4 | |a sleep | |
| 650 | 4 | |a sleep REM | |
| 650 | 4 | |a sleep architecture | |
| 650 | 4 | |a sleep slow-wave | |
| 650 | 4 | |a sleep stages | |
| 650 | 7 | |a Benzodiazepines |2 NLM | |
| 650 | 7 | |a 12794-10-4 |2 NLM | |
| 700 | 1 | |a de Mendonça, Giulia Paulo Rossi Ribeiro |e verfasserin |4 aut | |
| 700 | 1 | |a Souza, Laura Costa |e verfasserin |4 aut | |
| 700 | 1 | |a Galvão, Lucas Pequeno |e verfasserin |4 aut | |
| 700 | 1 | |a Paiva, Henrique Soares |e verfasserin |4 aut | |
| 700 | 1 | |a de Azevedo Marques Périco, Cintia |e verfasserin |4 aut | |
| 700 | 1 | |a Torales, Julio |e verfasserin |4 aut | |
| 700 | 1 | |a Ventriglio, Antonio |e verfasserin |4 aut | |
| 700 | 1 | |a Castaldelli-Maia, Joao Maurício |e verfasserin |4 aut | |
| 700 | 1 | |a Sousa Martins Silva, Anderson |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t CNS & neurological disorders drug targets |d 2006 |g 22(2023), 2 vom: 05., Seite 172-179 |w (DE-627)NLM161975518 |x 1996-3181 |7 nnns |
| 773 | 1 | 8 | |g volume:22 |g year:2023 |g number:2 |g day:05 |g pages:172-179 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.2174/1871527320666210618103344 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 22 |j 2023 |e 2 |b 05 |h 172-179 | ||