A cohort autopsy study defines COVID-19 systemic pathogenesis
© 2021. The Author(s)..
Severe COVID-19 disease caused by SARS-CoV-2 is frequently accompanied by dysfunction of the lungs and extrapulmonary organs. However, the organotropism of SARS-CoV-2 and the port of virus entry for systemic dissemination remain largely unknown. We profiled 26 COVID-19 autopsy cases from four cohorts in Wuhan, China, and determined the systemic distribution of SARS-CoV-2. SARS-CoV-2 was detected in the lungs and multiple extrapulmonary organs of critically ill COVID-19 patients up to 67 days after symptom onset. Based on organotropism and pathological features of the patients, COVID-19 was divided into viral intrapulmonary and systemic subtypes. In patients with systemic viral distribution, SARS-CoV-2 was detected in monocytes, macrophages, and vascular endothelia at blood-air barrier, blood-testis barrier, and filtration barrier. Critically ill patients with long disease duration showed decreased pulmonary cell proliferation, reduced viral RNA, and marked fibrosis in the lungs. Permanent SARS-CoV-2 presence and tissue injuries in the lungs and extrapulmonary organs suggest direct viral invasion as a mechanism of pathogenicity in critically ill patients. SARS-CoV-2 may hijack monocytes, macrophages, and vascular endothelia at physiological barriers as the ports of entry for systemic dissemination. Our study thus delineates systemic pathological features of SARS-CoV-2 infection, which sheds light on the development of novel COVID-19 treatment.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2021 |
|---|---|
| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:31 |
|---|---|
| Enthalten in: |
Cell research - 31(2021), 8 vom: 16. Aug., Seite 836-846 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Yao, Xiao-Hong [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
|---|
| Anmerkungen: |
Date Completed 13.08.2021 Date Revised 03.04.2024 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1038/s41422-021-00523-8 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM326830723 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM326830723 | ||
| 003 | DE-627 | ||
| 005 | 20240403232413.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231225s2021 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1038/s41422-021-00523-8 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1362.xml |
| 035 | |a (DE-627)NLM326830723 | ||
| 035 | |a (NLM)34135479 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Yao, Xiao-Hong |e verfasserin |4 aut | |
| 245 | 1 | 2 | |a A cohort autopsy study defines COVID-19 systemic pathogenesis |
| 264 | 1 | |c 2021 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 13.08.2021 | ||
| 500 | |a Date Revised 03.04.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2021. The Author(s). | ||
| 520 | |a Severe COVID-19 disease caused by SARS-CoV-2 is frequently accompanied by dysfunction of the lungs and extrapulmonary organs. However, the organotropism of SARS-CoV-2 and the port of virus entry for systemic dissemination remain largely unknown. We profiled 26 COVID-19 autopsy cases from four cohorts in Wuhan, China, and determined the systemic distribution of SARS-CoV-2. SARS-CoV-2 was detected in the lungs and multiple extrapulmonary organs of critically ill COVID-19 patients up to 67 days after symptom onset. Based on organotropism and pathological features of the patients, COVID-19 was divided into viral intrapulmonary and systemic subtypes. In patients with systemic viral distribution, SARS-CoV-2 was detected in monocytes, macrophages, and vascular endothelia at blood-air barrier, blood-testis barrier, and filtration barrier. Critically ill patients with long disease duration showed decreased pulmonary cell proliferation, reduced viral RNA, and marked fibrosis in the lungs. Permanent SARS-CoV-2 presence and tissue injuries in the lungs and extrapulmonary organs suggest direct viral invasion as a mechanism of pathogenicity in critically ill patients. SARS-CoV-2 may hijack monocytes, macrophages, and vascular endothelia at physiological barriers as the ports of entry for systemic dissemination. Our study thus delineates systemic pathological features of SARS-CoV-2 infection, which sheds light on the development of novel COVID-19 treatment | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 7 | |a RNA, Viral |2 NLM | |
| 700 | 1 | |a Luo, Tao |e verfasserin |4 aut | |
| 700 | 1 | |a Shi, Yu |e verfasserin |4 aut | |
| 700 | 1 | |a He, Zhi-Cheng |e verfasserin |4 aut | |
| 700 | 1 | |a Tang, Rui |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Pei-Pei |e verfasserin |4 aut | |
| 700 | 1 | |a Cai, Jun |e verfasserin |4 aut | |
| 700 | 1 | |a Zhou, Xiang-Dong |e verfasserin |4 aut | |
| 700 | 1 | |a Jiang, Dong-Po |e verfasserin |4 aut | |
| 700 | 1 | |a Fei, Xiao-Chun |e verfasserin |4 aut | |
| 700 | 1 | |a Huang, Xue-Quan |e verfasserin |4 aut | |
| 700 | 1 | |a Zhao, Lei |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Heng |e verfasserin |4 aut | |
| 700 | 1 | |a Wu, Hai-Bo |e verfasserin |4 aut | |
| 700 | 1 | |a Ren, Yong |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Zhen-Hua |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Hua-Rong |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Cong |e verfasserin |4 aut | |
| 700 | 1 | |a Fu, Wen-Juan |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Heng |e verfasserin |4 aut | |
| 700 | 1 | |a Xia, Xin-Yi |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Rong |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Yan |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Xin-Dong |e verfasserin |4 aut | |
| 700 | 1 | |a Yin, Chang-Lin |e verfasserin |4 aut | |
| 700 | 1 | |a Yan, Ze-Xuan |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Juan |e verfasserin |4 aut | |
| 700 | 1 | |a Jing, Rui |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Tai-Sheng |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Wei-Qin |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Chao-Fu |e verfasserin |4 aut | |
| 700 | 1 | |a Ding, Yan-Qing |e verfasserin |4 aut | |
| 700 | 1 | |a Mao, Qing |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Ding-Yu |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Shu-Yang |e verfasserin |4 aut | |
| 700 | 1 | |a Ping, Yi-Fang |e verfasserin |4 aut | |
| 700 | 1 | |a Bian, Xiu-Wu |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Cell research |d 1997 |g 31(2021), 8 vom: 16. Aug., Seite 836-846 |w (DE-627)NLM09215381X |x 1748-7838 |7 nnns |
| 773 | 1 | 8 | |g volume:31 |g year:2021 |g number:8 |g day:16 |g month:08 |g pages:836-846 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1038/s41422-021-00523-8 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 31 |j 2021 |e 8 |b 16 |c 08 |h 836-846 | ||