The mystery of 'saturation gap' and falsely normal G6PD : a case of primaquine-induced haemolysis in Plasmodium vivax malaria infection
Eradication therapy in Plasmodium vivax in variants of glucose-6-phosphate dehydrogenase (G6PD) deficiency individuals remains a clinical challenge. We present a case of primaquine-induced methaemoglobinaemia and haemolytic anaemia in a patient with falsely normal qualitative G6PD result during initial presentation, which was complicated with clinical sequelae of thrombosis. Further investigations showed moderate degree of G6PD deficiency. Our patient responded well to vitamin C and a modified weekly regimen of primaquine with no evidence of malaria relapse.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:51 |
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| Enthalten in: |
The journal of the Royal College of Physicians of Edinburgh - 51(2021), 2 vom: 06. Juni, Seite 146-148 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Tang, Andy Sing Ong [VerfasserIn] |
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| Links: |
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| Themen: |
Antimalarials |
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| Anmerkungen: |
Date Completed 28.07.2021 Date Revised 28.07.2021 published: Print Citation Status MEDLINE |
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| doi: |
10.4997/JRCPE.2021.210 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM326793240 |
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| 245 | 1 | 4 | |a The mystery of 'saturation gap' and falsely normal G6PD |b a case of primaquine-induced haemolysis in Plasmodium vivax malaria infection |
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| 520 | |a Eradication therapy in Plasmodium vivax in variants of glucose-6-phosphate dehydrogenase (G6PD) deficiency individuals remains a clinical challenge. We present a case of primaquine-induced methaemoglobinaemia and haemolytic anaemia in a patient with falsely normal qualitative G6PD result during initial presentation, which was complicated with clinical sequelae of thrombosis. Further investigations showed moderate degree of G6PD deficiency. Our patient responded well to vitamin C and a modified weekly regimen of primaquine with no evidence of malaria relapse | ||
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| 700 | 1 | |a Mansor, Nor Ainiza |e verfasserin |4 aut | |
| 700 | 1 | |a Chew, Lee Ping |e verfasserin |4 aut | |
| 700 | 1 | |a Chua, Hock Hin |e verfasserin |4 aut | |
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