Could fibrinogen to albumin ratio be a predictive marker for recurrent pregnancy loss
© 2021 John Wiley & Sons Ltd..
AIMS: Recurrent pregnancy loss (RPL) is usually defined by two or more consecutive clinical miscarriages, which causes psychological trauma for couples. In this study, we aimed to investigate the predictive role of fibrinogen to albumin ratio (FAR) in patients with RPL.
METHODS: Pregnant women in their first trimester of pregnancy were included in the study and divided into two groups as RPL patients (n: 44) and patients with no previous recurrent miscarriage (n: 60) as control group. Demographical parameters and routine blood parameters (fibrinogen, D-dimer, FAR, neutrophil to lymphocyte ratio [NLR], platelet count, main platelet volume [MPV], and red cell distribution width [RDW] values) were compared between the RPL group and the control group.
RESULTS: The groups were determined to be statistically different in regard to gravidity and parity (P < .001). The difference between the groups was statistically different in regard to fibrinogen (mg/dL), albumin (g/dL), FAR (%), NLR (%), RDW-coefficient of variation (%), RDW-standard deviation (fl), and platelet counts (10-3 /μL). However, MPV (fl) and D-dimer (μg/L) levels were similar in both groups. The receiver operating characteristic curve analysis revealed that the NLR levels were 84.1% sensitive and 75% specific with a cut-off value of 4.27 and the FAR levels were 79.5% sensitive and 88.3% specific with a cut-off value of 105.69 for predicting RPL.
CONCLUSION: Our results indicate that the FAR and NLR levels seem to be effective parameters for predicting RPL with high sensitivity and specificity.
Medienart: |
E-Artikel |
---|
Erscheinungsjahr: |
2021 |
---|---|
Erschienen: |
2021 |
Enthalten in: |
Zur Gesamtaufnahme - volume:75 |
---|---|
Enthalten in: |
International journal of clinical practice - 75(2021), 10 vom: 15. Okt., Seite e14520 |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Cimsir, Meral Tugba [VerfasserIn] |
---|
Links: |
---|
Themen: |
---|
Anmerkungen: |
Date Completed 21.09.2021 Date Revised 21.09.2021 published: Print-Electronic Citation Status MEDLINE |
---|
doi: |
10.1111/ijcp.14520 |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
NLM326682848 |
---|
LEADER | 01000naa a22002652 4500 | ||
---|---|---|---|
001 | NLM326682848 | ||
003 | DE-627 | ||
005 | 20231225195126.0 | ||
007 | cr uuu---uuuuu | ||
008 | 231225s2021 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.1111/ijcp.14520 |2 doi | |
028 | 5 | 2 | |a pubmed24n1088.xml |
035 | |a (DE-627)NLM326682848 | ||
035 | |a (NLM)34120391 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 1 | |a Cimsir, Meral Tugba |e verfasserin |4 aut | |
245 | 1 | 0 | |a Could fibrinogen to albumin ratio be a predictive marker for recurrent pregnancy loss |
264 | 1 | |c 2021 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ƒaComputermedien |b c |2 rdamedia | ||
338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
500 | |a Date Completed 21.09.2021 | ||
500 | |a Date Revised 21.09.2021 | ||
500 | |a published: Print-Electronic | ||
500 | |a Citation Status MEDLINE | ||
520 | |a © 2021 John Wiley & Sons Ltd. | ||
520 | |a AIMS: Recurrent pregnancy loss (RPL) is usually defined by two or more consecutive clinical miscarriages, which causes psychological trauma for couples. In this study, we aimed to investigate the predictive role of fibrinogen to albumin ratio (FAR) in patients with RPL | ||
520 | |a METHODS: Pregnant women in their first trimester of pregnancy were included in the study and divided into two groups as RPL patients (n: 44) and patients with no previous recurrent miscarriage (n: 60) as control group. Demographical parameters and routine blood parameters (fibrinogen, D-dimer, FAR, neutrophil to lymphocyte ratio [NLR], platelet count, main platelet volume [MPV], and red cell distribution width [RDW] values) were compared between the RPL group and the control group | ||
520 | |a RESULTS: The groups were determined to be statistically different in regard to gravidity and parity (P < .001). The difference between the groups was statistically different in regard to fibrinogen (mg/dL), albumin (g/dL), FAR (%), NLR (%), RDW-coefficient of variation (%), RDW-standard deviation (fl), and platelet counts (10-3 /μL). However, MPV (fl) and D-dimer (μg/L) levels were similar in both groups. The receiver operating characteristic curve analysis revealed that the NLR levels were 84.1% sensitive and 75% specific with a cut-off value of 4.27 and the FAR levels were 79.5% sensitive and 88.3% specific with a cut-off value of 105.69 for predicting RPL | ||
520 | |a CONCLUSION: Our results indicate that the FAR and NLR levels seem to be effective parameters for predicting RPL with high sensitivity and specificity | ||
650 | 4 | |a Journal Article | |
650 | 7 | |a Albumins |2 NLM | |
650 | 7 | |a Biomarkers |2 NLM | |
650 | 7 | |a Fibrinogen |2 NLM | |
650 | 7 | |a 9001-32-5 |2 NLM | |
700 | 1 | |a Yildiz, Muhammet Serhat |e verfasserin |4 aut | |
773 | 0 | 8 | |i Enthalten in |t International journal of clinical practice |d 1998 |g 75(2021), 10 vom: 15. Okt., Seite e14520 |w (DE-627)NLM092403344 |x 1742-1241 |7 nnns |
773 | 1 | 8 | |g volume:75 |g year:2021 |g number:10 |g day:15 |g month:10 |g pages:e14520 |
856 | 4 | 0 | |u http://dx.doi.org/10.1111/ijcp.14520 |3 Volltext |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_NLM | ||
951 | |a AR | ||
952 | |d 75 |j 2021 |e 10 |b 15 |c 10 |h e14520 |