Microfibrillated cellulose films containing chitosan and tannic acid for wound healing applications
The effectiveness of tannic acid as antimicrobial and wound healing for burns have been shown for a century; however, uncontrolled target dosage may result in undesirable side-effects. Remarkably, tannic acid polyphenols compounds crosslinked with polymeric materials produce a strong composite containing the beneficial properties of this tannin. However, investigation of the crosslink structure and its antibacterial and regenerative properties are still unknown when using nanocellulose by mechanical defibrillation; additionally, due to the potential crosslink structure with chitosan, its structure can be complex. Therefore, this work uses bleach kraft nanocellulose in order to investigate the effect on the physical and regenerative properties when incorporated with chitosan and tannic acid. This film results in increased rigidity with a lamellar structure when incorporated with tannic acid due to its strong hydrogen bonding. The release of tannic acid varied depending on the structure it was synthesised with, whereas with chitosan it presented good release model compared to pure cellulose. In addition, exhibiting similar thermal stability as pure cellulose films with antibacterial properties tested against S. aureus and E. coli with good metabolic cellular viability while also inhibiting NF-κB activity, a characteristic of tannic acid.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:32 |
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| Enthalten in: |
Journal of materials science. Materials in medicine - 32(2021), 6 vom: 12. Juni, Seite 67 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Aliabadi, Meysam [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 20.12.2021 Date Revised 20.12.2021 published: Electronic Citation Status MEDLINE |
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| doi: |
10.1007/s10856-021-06536-4 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM326658335 |
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| 100 | 1 | |a Aliabadi, Meysam |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Microfibrillated cellulose films containing chitosan and tannic acid for wound healing applications |
| 264 | 1 | |c 2021 | |
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| 500 | |a Date Revised 20.12.2021 | ||
| 500 | |a published: Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a The effectiveness of tannic acid as antimicrobial and wound healing for burns have been shown for a century; however, uncontrolled target dosage may result in undesirable side-effects. Remarkably, tannic acid polyphenols compounds crosslinked with polymeric materials produce a strong composite containing the beneficial properties of this tannin. However, investigation of the crosslink structure and its antibacterial and regenerative properties are still unknown when using nanocellulose by mechanical defibrillation; additionally, due to the potential crosslink structure with chitosan, its structure can be complex. Therefore, this work uses bleach kraft nanocellulose in order to investigate the effect on the physical and regenerative properties when incorporated with chitosan and tannic acid. This film results in increased rigidity with a lamellar structure when incorporated with tannic acid due to its strong hydrogen bonding. The release of tannic acid varied depending on the structure it was synthesised with, whereas with chitosan it presented good release model compared to pure cellulose. In addition, exhibiting similar thermal stability as pure cellulose films with antibacterial properties tested against S. aureus and E. coli with good metabolic cellular viability while also inhibiting NF-κB activity, a characteristic of tannic acid | ||
| 650 | 4 | |a Journal Article | |
| 650 | 7 | |a Anti-Bacterial Agents |2 NLM | |
| 650 | 7 | |a Anti-Infective Agents |2 NLM | |
| 650 | 7 | |a Antioxidants |2 NLM | |
| 650 | 7 | |a Benzothiazoles |2 NLM | |
| 650 | 7 | |a Biphenyl Compounds |2 NLM | |
| 650 | 7 | |a Cross-Linking Reagents |2 NLM | |
| 650 | 7 | |a Gels |2 NLM | |
| 650 | 7 | |a NF-kappa B |2 NLM | |
| 650 | 7 | |a Picrates |2 NLM | |
| 650 | 7 | |a Polyphenols |2 NLM | |
| 650 | 7 | |a Sulfonic Acids |2 NLM | |
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| 650 | 7 | |a 2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid |2 NLM | |
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| 700 | 1 | |a Chee, Bor Shin |e verfasserin |4 aut | |
| 700 | 1 | |a Matos, Mailson |e verfasserin |4 aut | |
| 700 | 1 | |a Cortese, Yvonne J |e verfasserin |4 aut | |
| 700 | 1 | |a Nugent, Michael J D |e verfasserin |4 aut | |
| 700 | 1 | |a de Lima, Tielidy A M |e verfasserin |4 aut | |
| 700 | 1 | |a Magalhães, Washington L E |e verfasserin |4 aut | |
| 700 | 1 | |a de Lima, Gabriel Goetten |e verfasserin |4 aut | |
| 700 | 1 | |a Firouzabadi, Mohammadreza Dehghani |e verfasserin |4 aut | |
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