Serum calprotectin (S100A8/A9) : a promising biomarker in diagnosis and follow-up in different subgroups of juvenile idiopathic arthritis
© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ..
INTRODUCTION: In the management of juvenile idiopathic arthritis (JIA), there is a lack of diagnostic and prognostic biomarkers. This study assesses the use of serum calprotectin (sCal) as a marker to monitor disease activity, and as a classification and prognosis tool of response to treatment or risk of flares in patients with JIA.
METHODS: Eighty-one patients with JIA from the CAP48 multicentric cohort were included in this study, as well as 11 non-paediatric healthy controls. An ELISA method was used to quantify sCal with a commercial kit.
RESULTS: Patients with an active disease compared with healthy controls and with patients with inactive disease showed an eightfold and a twofold increased level of sCal, respectively. sCal was found to be correlated with the C-reactive protein (CRP) and even more strongly with the erythrocyte sedimentation rate. Evolution of DAS28 scores correlated well with evolution of sCal, as opposed to evolution of CRP. With regard to CRP, sCal could differentiate forms with active oligoarthritis from polyarthritis and systemic forms. However, sCal brought an added value compared with the CRP as a prognosis marker. Indeed, patients with active disease and reaching minimal disease activity (according to Juvenile Arthritis Disease Activity Score) at 6 months following the test had higher sCal levels, while patients with inactive disease had higher sCal levels if a flare was observed up to 3-9 months following the test.
CONCLUSIONS: This study confirms the potential uses of sCal as a biomarker in the diagnosis and follow-up of JIA.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2021 |
|---|---|
| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:7 |
|---|---|
| Enthalten in: |
RMD open - 7(2021), 2 vom: 09. Juni |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
La, Céline [VerfasserIn] |
|---|
| Links: |
|---|
| Anmerkungen: |
Date Completed 31.08.2021 Date Revised 31.05.2022 published: Print Citation Status MEDLINE |
|---|
| doi: |
10.1136/rmdopen-2021-001646 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM326562702 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM326562702 | ||
| 003 | DE-627 | ||
| 005 | 20231225194850.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231225s2021 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1136/rmdopen-2021-001646 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1088.xml |
| 035 | |a (DE-627)NLM326562702 | ||
| 035 | |a (NLM)34108235 | ||
| 035 | |a (PII)e001646 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a La, Céline |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Serum calprotectin (S100A8/A9) |b a promising biomarker in diagnosis and follow-up in different subgroups of juvenile idiopathic arthritis |
| 264 | 1 | |c 2021 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 31.08.2021 | ||
| 500 | |a Date Revised 31.05.2022 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. | ||
| 520 | |a INTRODUCTION: In the management of juvenile idiopathic arthritis (JIA), there is a lack of diagnostic and prognostic biomarkers. This study assesses the use of serum calprotectin (sCal) as a marker to monitor disease activity, and as a classification and prognosis tool of response to treatment or risk of flares in patients with JIA | ||
| 520 | |a METHODS: Eighty-one patients with JIA from the CAP48 multicentric cohort were included in this study, as well as 11 non-paediatric healthy controls. An ELISA method was used to quantify sCal with a commercial kit | ||
| 520 | |a RESULTS: Patients with an active disease compared with healthy controls and with patients with inactive disease showed an eightfold and a twofold increased level of sCal, respectively. sCal was found to be correlated with the C-reactive protein (CRP) and even more strongly with the erythrocyte sedimentation rate. Evolution of DAS28 scores correlated well with evolution of sCal, as opposed to evolution of CRP. With regard to CRP, sCal could differentiate forms with active oligoarthritis from polyarthritis and systemic forms. However, sCal brought an added value compared with the CRP as a prognosis marker. Indeed, patients with active disease and reaching minimal disease activity (according to Juvenile Arthritis Disease Activity Score) at 6 months following the test had higher sCal levels, while patients with inactive disease had higher sCal levels if a flare was observed up to 3-9 months following the test | ||
| 520 | |a CONCLUSIONS: This study confirms the potential uses of sCal as a biomarker in the diagnosis and follow-up of JIA | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a health care | |
| 650 | 4 | |a inflammation | |
| 650 | 4 | |a juvenile idiopathic arthritis | |
| 650 | 4 | |a outcome assessment | |
| 650 | 7 | |a Biomarkers |2 NLM | |
| 650 | 7 | |a Calgranulin A |2 NLM | |
| 650 | 7 | |a Calgranulin B |2 NLM | |
| 650 | 7 | |a Leukocyte L1 Antigen Complex |2 NLM | |
| 650 | 7 | |a S100A8 protein, human |2 NLM | |
| 650 | 7 | |a S100A9 protein, human |2 NLM | |
| 700 | 1 | |a Lê, Phu Quoc |e verfasserin |4 aut | |
| 700 | 1 | |a Ferster, Alina |e verfasserin |4 aut | |
| 700 | 1 | |a Goffin, Laurence |e verfasserin |4 aut | |
| 700 | 1 | |a Spruyt, Delphine |e verfasserin |4 aut | |
| 700 | 1 | |a Lauwerys, Bernard |e verfasserin |4 aut | |
| 700 | 1 | |a Durez, Patrick |e verfasserin |4 aut | |
| 700 | 1 | |a Boulanger, Cecile |e verfasserin |4 aut | |
| 700 | 1 | |a Sokolova, Tatiana |e verfasserin |4 aut | |
| 700 | 1 | |a Rasschaert, Joanne |e verfasserin |4 aut | |
| 700 | 1 | |a Badot, Valérie |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t RMD open |d 2015 |g 7(2021), 2 vom: 09. Juni |w (DE-627)NLM254089658 |x 2056-5933 |7 nnns |
| 773 | 1 | 8 | |g volume:7 |g year:2021 |g number:2 |g day:09 |g month:06 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1136/rmdopen-2021-001646 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 7 |j 2021 |e 2 |b 09 |c 06 | ||