Epithelial-mesenchymal transition induced by SARS-CoV-2 required transcriptional upregulation of Snail
AJCR Copyright © 2021..
The engagement of human angiotensin-converting enzyme 2 (hACE2) and SARS-CoV-2 spike protein facilitate virus spread. Thus far, ACE2 and TMPRSS2 expression is correlated with the epithelial-mesenchymal transition (EMT) gene signature in lung cancer. However, the mechanism for SARS-CoV-2-induced EMT has not been thoroughly explored. Here, we showed that SARS-CoV-2 induces EMT phenotypic change and stemness in breast cancer cell model and subsequently identified Snail as a modulator for this regulation. The in-depth analysis identifies the spike protein (S), but not envelope (E), nucleocapsid (N), or membrane protein (M), of SARS-CoV-2 induces EMT marker changes. Suppression of Snail expression in these cells abrogates S protein-induced invasion, migration, stemness, and lung metastasis, suggesting that Snail is required for SARS-CoV-2-mediated aggressive phenotype in cancer. This study reveals an important oncogenic role of SARS-CoV-2 in triggering breast cancer metastasis through Snail upregulation.
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:11 |
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| Enthalten in: |
American journal of cancer research - 11(2021), 5 vom: 04., Seite 2278-2290 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Lai, Yun-Ju [VerfasserIn] |
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| Themen: |
ACE2 |
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| Anmerkungen: |
Date Revised 08.06.2021 published: Electronic-eCollection Citation Status PubMed-not-MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM326429085 |
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| 500 | |a published: Electronic-eCollection | ||
| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a AJCR Copyright © 2021. | ||
| 520 | |a The engagement of human angiotensin-converting enzyme 2 (hACE2) and SARS-CoV-2 spike protein facilitate virus spread. Thus far, ACE2 and TMPRSS2 expression is correlated with the epithelial-mesenchymal transition (EMT) gene signature in lung cancer. However, the mechanism for SARS-CoV-2-induced EMT has not been thoroughly explored. Here, we showed that SARS-CoV-2 induces EMT phenotypic change and stemness in breast cancer cell model and subsequently identified Snail as a modulator for this regulation. The in-depth analysis identifies the spike protein (S), but not envelope (E), nucleocapsid (N), or membrane protein (M), of SARS-CoV-2 induces EMT marker changes. Suppression of Snail expression in these cells abrogates S protein-induced invasion, migration, stemness, and lung metastasis, suggesting that Snail is required for SARS-CoV-2-mediated aggressive phenotype in cancer. This study reveals an important oncogenic role of SARS-CoV-2 in triggering breast cancer metastasis through Snail upregulation | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a ACE2 | |
| 650 | 4 | |a EMT | |
| 650 | 4 | |a SARS-CoV-2 | |
| 650 | 4 | |a Snail | |
| 650 | 4 | |a TMPRSS2 | |
| 650 | 4 | |a epithelial-mesenchymal transition | |
| 650 | 4 | |a spike | |
| 700 | 1 | |a Chao, Chi-Hong |e verfasserin |4 aut | |
| 700 | 1 | |a Liao, Chun-Che |e verfasserin |4 aut | |
| 700 | 1 | |a Lee, Te-An |e verfasserin |4 aut | |
| 700 | 1 | |a Hsu, Jung-Mao |e verfasserin |4 aut | |
| 700 | 1 | |a Chou, Wen-Cheng |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Jyun |e verfasserin |4 aut | |
| 700 | 1 | |a Huang, Hsiang-Chi |e verfasserin |4 aut | |
| 700 | 1 | |a Chang, Shing-Jyh |e verfasserin |4 aut | |
| 700 | 1 | |a Lin, Yi-Ling |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Chia-Wei |e verfasserin |4 aut | |
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