Sex Representation Among Principal Investigators in Cardiac Surgery Clinical Trials in the United States : The Glass Ceiling and Room for Improvement
Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved..
OBJECTIVE: The aim of this study was to determine the sex representation among principal investigators (PIs) in US cardiac surgery clinical trials.
SUMMARY BACKGROUND DATA: Being a principal investigator in a US clinical trial confers national recognition among peers. Sex representation among principal investigators (PIs) in US cardiac surgery clinical trials has not been evaluated.
METHODS: We evaluated 124 US cardiac surgery trials registered on Clin-icalTrials.gov from 2014 to 2019. Sixty trials included PIs (n = 266) from 128 institutions that had a combined total of 1040 adult cardiac surgeons. We examined sex representation among junior-level (instructor or assistant professor) and senior-level (associate, full, or Emeritus professor) PIs by calculating the participation-to-prevalence ratio (PPR), whereby a PPR range of 0.8 to 1.2 reflects equitable representation.
RESULTS: The pool representation percentage was 6.1% (63/1040) for women and 93.9% (977/1040) for men. A total of 266 PI positions were assigned to adult cardiac surgeons: 6 (9.5%; PPR = 0.37) from the female pool and 260 (26.6%; PPR = 1.04) from the male pool ( P = 0.004). The percentage of PIs with studies funded by industry was 9.5% ofthe female pool (PPR = 0.39) and 25.0% of the male pool (PPR = 1.04) ( P = 0.009). No National Institutes of Health-funded or other funded trials had female PIs. An overall trend was observed toward disproportionally more men than women among PIs, especially at the senior level ( P = 0.027).
CONCLUSIONS: Equitable opportunities for PI positions are available for junior-level but not senior-level cardiothoracic surgeons. These results suggest a need for active engagement and promotion of equal opportunities in cardiac surgery.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:276 |
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| Enthalten in: |
Annals of surgery - 276(2022), 6 vom: 01. Dez., Seite e1101-e1106 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Nguyen, Quynh [VerfasserIn] |
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| Anmerkungen: |
Date Completed 10.11.2022 Date Revised 10.12.2022 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1097/SLA.0000000000004961 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM326397485 |
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| 500 | |a Date Revised 10.12.2022 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved. | ||
| 520 | |a OBJECTIVE: The aim of this study was to determine the sex representation among principal investigators (PIs) in US cardiac surgery clinical trials | ||
| 520 | |a SUMMARY BACKGROUND DATA: Being a principal investigator in a US clinical trial confers national recognition among peers. Sex representation among principal investigators (PIs) in US cardiac surgery clinical trials has not been evaluated | ||
| 520 | |a METHODS: We evaluated 124 US cardiac surgery trials registered on Clin-icalTrials.gov from 2014 to 2019. Sixty trials included PIs (n = 266) from 128 institutions that had a combined total of 1040 adult cardiac surgeons. We examined sex representation among junior-level (instructor or assistant professor) and senior-level (associate, full, or Emeritus professor) PIs by calculating the participation-to-prevalence ratio (PPR), whereby a PPR range of 0.8 to 1.2 reflects equitable representation | ||
| 520 | |a RESULTS: The pool representation percentage was 6.1% (63/1040) for women and 93.9% (977/1040) for men. A total of 266 PI positions were assigned to adult cardiac surgeons: 6 (9.5%; PPR = 0.37) from the female pool and 260 (26.6%; PPR = 1.04) from the male pool ( P = 0.004). The percentage of PIs with studies funded by industry was 9.5% ofthe female pool (PPR = 0.39) and 25.0% of the male pool (PPR = 1.04) ( P = 0.009). No National Institutes of Health-funded or other funded trials had female PIs. An overall trend was observed toward disproportionally more men than women among PIs, especially at the senior level ( P = 0.027) | ||
| 520 | |a CONCLUSIONS: Equitable opportunities for PI positions are available for junior-level but not senior-level cardiothoracic surgeons. These results suggest a need for active engagement and promotion of equal opportunities in cardiac surgery | ||
| 650 | 4 | |a Journal Article | |
| 700 | 1 | |a Luc, Jessica G Y |e verfasserin |4 aut | |
| 700 | 1 | |a Lawton, Jennifer S |e verfasserin |4 aut | |
| 700 | 1 | |a Chikwe, Joanna |e verfasserin |4 aut | |
| 700 | 1 | |a Cornwell, Lorraine D |e verfasserin |4 aut | |
| 700 | 1 | |a Simpson, Katherine |e verfasserin |4 aut | |
| 700 | 1 | |a Estrera, Anthony L |e verfasserin |4 aut | |
| 700 | 1 | |a Moon, Marc R |e verfasserin |4 aut | |
| 700 | 1 | |a Preventza, Ourania |e verfasserin |4 aut | |
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