Measurements of Bone Health after Thyroid-Stimulating Suppression Therapy in Postmenopausal Women with Differentiated Thyroid Carcinoma : Bone Mineral Density versus the Trabecular Bone Score
BACKGROUND: Thyroid-stimulating hormone (TSH) suppression therapy is an important treatment modality for differentiated thyroid carcinoma (DTC), but it increases fracture risk. The aim of this study was to evaluate changes in bone mineral density (BMD) and trabecular bone score (TBS) in postmenopausal DTC patients receiving TSH suppression therapy.
METHODS: A total of 410 postmenopausal DTC patients who underwent thyroidectomy and had at least two dual-energy X-ray absorptiometry measurements, including a preoperative measurement, were included. Patients who had osteoporosis medication for more than 1 year were classified as 'patients with osteoporosis'.
RESULTS: In patients without osteoporosis, the change in %BMD was similar between TSH suppression (-) and (+) groups, while the decrease in %TBS was significantly greater in the TSH suppression (+) group than that of the TSH suppression (-) group. The relative risk of vertebral fracture was decreased by TBS changes but not by BMD changes. In patients with osteoporosis, both BMD and TBS showed significant increases in the TSH suppression (-) group but not in TSH suppression (+) group. At year 4, TBS was significantly lower in the TSH suppression (+) group than that in the TSH suppression (-) group, while BMD showed no difference between groups.
CONCLUSIONS: TBS may better reflect bone health than BMD in postmenopausal DTC patients with TSH suppression therapy.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:10 |
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| Enthalten in: |
Journal of clinical medicine - 10(2021), 9 vom: 03. Mai |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Chung, Chae Won [VerfasserIn] |
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| Links: |
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| Themen: |
Bone mineral density |
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| Anmerkungen: |
Date Revised 05.06.2021 published: Electronic Citation Status PubMed-not-MEDLINE |
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| doi: |
10.3390/jcm10091964 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM326122192 |
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| 100 | 1 | |a Chung, Chae Won |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Measurements of Bone Health after Thyroid-Stimulating Suppression Therapy in Postmenopausal Women with Differentiated Thyroid Carcinoma |b Bone Mineral Density versus the Trabecular Bone Score |
| 264 | 1 | |c 2021 | |
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| 500 | |a Date Revised 05.06.2021 | ||
| 500 | |a published: Electronic | ||
| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a BACKGROUND: Thyroid-stimulating hormone (TSH) suppression therapy is an important treatment modality for differentiated thyroid carcinoma (DTC), but it increases fracture risk. The aim of this study was to evaluate changes in bone mineral density (BMD) and trabecular bone score (TBS) in postmenopausal DTC patients receiving TSH suppression therapy | ||
| 520 | |a METHODS: A total of 410 postmenopausal DTC patients who underwent thyroidectomy and had at least two dual-energy X-ray absorptiometry measurements, including a preoperative measurement, were included. Patients who had osteoporosis medication for more than 1 year were classified as 'patients with osteoporosis' | ||
| 520 | |a RESULTS: In patients without osteoporosis, the change in %BMD was similar between TSH suppression (-) and (+) groups, while the decrease in %TBS was significantly greater in the TSH suppression (+) group than that of the TSH suppression (-) group. The relative risk of vertebral fracture was decreased by TBS changes but not by BMD changes. In patients with osteoporosis, both BMD and TBS showed significant increases in the TSH suppression (-) group but not in TSH suppression (+) group. At year 4, TBS was significantly lower in the TSH suppression (+) group than that in the TSH suppression (-) group, while BMD showed no difference between groups | ||
| 520 | |a CONCLUSIONS: TBS may better reflect bone health than BMD in postmenopausal DTC patients with TSH suppression therapy | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a TSH suppression therapy | |
| 650 | 4 | |a bone mineral density | |
| 650 | 4 | |a differentiated thyroid carcinoma | |
| 650 | 4 | |a trabecular bone score | |
| 700 | 1 | |a Choi, Hoon Sung |e verfasserin |4 aut | |
| 700 | 1 | |a Kong, Sung Hye |e verfasserin |4 aut | |
| 700 | 1 | |a Park, Young Joo |e verfasserin |4 aut | |
| 700 | 1 | |a Park, Do Joon |e verfasserin |4 aut | |
| 700 | 1 | |a Ahn, Hwa Young |e verfasserin |4 aut | |
| 700 | 1 | |a Cho, Sun Wook |e verfasserin |4 aut | |
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