Development of a multi-patient ventilator circuit with validation in an ARDS porcine model

© 2021. Japanese Society of Anesthesiologists..

PURPOSE: The COVID-19 pandemic threatens our current ICU capabilities nationwide. As the number of COVID-19 positive patients across the nation continues to increase, the need for options to address ventilator shortages is inevitable. Multi-patient ventilation (MPV), in which more than one patient can use a single ventilator base unit, has been proposed as a potential solution to this problem. To our knowledge, this option has been discussed but remains untested in live patients with differing severity of lung pathology.

METHODS: The objective of this study was to address ventilator shortages and patient stacking limitations by developing and validating a modified breathing circuit for two patients with differing lung compliances using simple, off-the-shelf components. A multi-patient ventilator circuit (MPVC) was simulated with a mathematical model and validated with four animal studies. Each animal study had two human-sized pigs: one healthy and one with lipopolysaccharide (LPS) induced ARDS. LPS was chosen because it lowers lung compliance similar to COVID-19. In a previous study, a control group of four pigs was given ARDS and placed on a single patient ventilation circuit (SPVC). The oxygenation of the MPVC ARDS animals was then compared to the oxygenation of the SPVC animals.

RESULTS: Based on the comparisons, similar oxygenation and morbidity rates were observed between the MPVC ARDS animals and the SPVC animals.

CONCLUSION: As healthcare systems worldwide deal with inundated ICUs and hospitals from pandemics, they could potentially benefit from this approach by providing more patients with respiratory care.

Medienart:

E-Artikel

Erscheinungsjahr:

2021

Erschienen:

2021

Enthalten in:

Zur Gesamtaufnahme - volume:35

Enthalten in:

Journal of anesthesia - 35(2021), 4 vom: 01. Aug., Seite 543-554

Sprache:

Englisch

Beteiligte Personen:

Wankum, Benjamin P [VerfasserIn]
Reynolds, Riley E [VerfasserIn]
McCain, Andrea R [VerfasserIn]
Zollinger, Nathaniel T [VerfasserIn]
Buesing, Keely L [VerfasserIn]
Sindelar, Russel D [VerfasserIn]
Freihaut, Frank M [VerfasserIn]
Fekadu, Tariku [VerfasserIn]
Terry, Benjamin S [VerfasserIn]

Links:

Volltext

Themen:

Artificial respiration
COVID-19
Coronavirus
Journal Article
Pandemics
Research Support, Non-U.S. Gov't
Viruses

Anmerkungen:

Date Completed 30.07.2021

Date Revised 18.02.2022

published: Print-Electronic

Citation Status MEDLINE

doi:

10.1007/s00540-021-02948-2

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM326097775