Development of a multi-patient ventilator circuit with validation in an ARDS porcine model
© 2021. Japanese Society of Anesthesiologists..
PURPOSE: The COVID-19 pandemic threatens our current ICU capabilities nationwide. As the number of COVID-19 positive patients across the nation continues to increase, the need for options to address ventilator shortages is inevitable. Multi-patient ventilation (MPV), in which more than one patient can use a single ventilator base unit, has been proposed as a potential solution to this problem. To our knowledge, this option has been discussed but remains untested in live patients with differing severity of lung pathology.
METHODS: The objective of this study was to address ventilator shortages and patient stacking limitations by developing and validating a modified breathing circuit for two patients with differing lung compliances using simple, off-the-shelf components. A multi-patient ventilator circuit (MPVC) was simulated with a mathematical model and validated with four animal studies. Each animal study had two human-sized pigs: one healthy and one with lipopolysaccharide (LPS) induced ARDS. LPS was chosen because it lowers lung compliance similar to COVID-19. In a previous study, a control group of four pigs was given ARDS and placed on a single patient ventilation circuit (SPVC). The oxygenation of the MPVC ARDS animals was then compared to the oxygenation of the SPVC animals.
RESULTS: Based on the comparisons, similar oxygenation and morbidity rates were observed between the MPVC ARDS animals and the SPVC animals.
CONCLUSION: As healthcare systems worldwide deal with inundated ICUs and hospitals from pandemics, they could potentially benefit from this approach by providing more patients with respiratory care.
Medienart: |
E-Artikel |
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Erscheinungsjahr: |
2021 |
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Erschienen: |
2021 |
Enthalten in: |
Zur Gesamtaufnahme - volume:35 |
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Enthalten in: |
Journal of anesthesia - 35(2021), 4 vom: 01. Aug., Seite 543-554 |
Sprache: |
Englisch |
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Beteiligte Personen: |
Wankum, Benjamin P [VerfasserIn] |
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Links: |
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Themen: |
Artificial respiration |
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Anmerkungen: |
Date Completed 30.07.2021 Date Revised 18.02.2022 published: Print-Electronic Citation Status MEDLINE |
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doi: |
10.1007/s00540-021-02948-2 |
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funding: |
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Förderinstitution / Projekttitel: |
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PPN (Katalog-ID): |
NLM326097775 |
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500 | |a Citation Status MEDLINE | ||
520 | |a © 2021. Japanese Society of Anesthesiologists. | ||
520 | |a PURPOSE: The COVID-19 pandemic threatens our current ICU capabilities nationwide. As the number of COVID-19 positive patients across the nation continues to increase, the need for options to address ventilator shortages is inevitable. Multi-patient ventilation (MPV), in which more than one patient can use a single ventilator base unit, has been proposed as a potential solution to this problem. To our knowledge, this option has been discussed but remains untested in live patients with differing severity of lung pathology | ||
520 | |a METHODS: The objective of this study was to address ventilator shortages and patient stacking limitations by developing and validating a modified breathing circuit for two patients with differing lung compliances using simple, off-the-shelf components. A multi-patient ventilator circuit (MPVC) was simulated with a mathematical model and validated with four animal studies. Each animal study had two human-sized pigs: one healthy and one with lipopolysaccharide (LPS) induced ARDS. LPS was chosen because it lowers lung compliance similar to COVID-19. In a previous study, a control group of four pigs was given ARDS and placed on a single patient ventilation circuit (SPVC). The oxygenation of the MPVC ARDS animals was then compared to the oxygenation of the SPVC animals | ||
520 | |a RESULTS: Based on the comparisons, similar oxygenation and morbidity rates were observed between the MPVC ARDS animals and the SPVC animals | ||
520 | |a CONCLUSION: As healthcare systems worldwide deal with inundated ICUs and hospitals from pandemics, they could potentially benefit from this approach by providing more patients with respiratory care | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a Research Support, Non-U.S. Gov't | |
650 | 4 | |a Artificial respiration | |
650 | 4 | |a COVID-19 | |
650 | 4 | |a Coronavirus | |
650 | 4 | |a Pandemics | |
650 | 4 | |a Viruses | |
700 | 1 | |a Reynolds, Riley E |e verfasserin |4 aut | |
700 | 1 | |a McCain, Andrea R |e verfasserin |4 aut | |
700 | 1 | |a Zollinger, Nathaniel T |e verfasserin |4 aut | |
700 | 1 | |a Buesing, Keely L |e verfasserin |4 aut | |
700 | 1 | |a Sindelar, Russel D |e verfasserin |4 aut | |
700 | 1 | |a Freihaut, Frank M |e verfasserin |4 aut | |
700 | 1 | |a Fekadu, Tariku |e verfasserin |4 aut | |
700 | 1 | |a Terry, Benjamin S |e verfasserin |4 aut | |
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