Histopathological features in fatal COVID-19 acute respiratory distress syndrome
Copyright © 2021 Elsevier España, S.L.U. and SEMICYUC. All rights reserved..
BACKGROUND: COVID-19 acute respiratory distress syndrome (ARDS) shares the common histological hallmarks with other forms of ARDS. However, the chronology of the histological lesions has not been well established.
OBJECTIVE: To describe the chronological histopathological alterations in the lungs of patients with COVID-19 related ARDS.
DESIGN: A prospective cohort study was carried out.
SETTING: Intensive Care Unit of a tertiary hospital.
PATIENTS: The first 22 consecutive COVID-19 deaths.
MEASUREMENTS: Lung biopsies and histopathological analyses were performed in deceased patients with COVID-19 related ARDS. Clinical data and patient course were evaluated.
RESULTS: The median patient age was 66 [63-74] years; 73% were males. The median duration of mechanical ventilation was 17 [8-24] days. COVID-19 induced pulmonary injury was characterized by an exudative phase in the first week of the disease, followed by a proliferative/organizing phase in the second and third weeks, and finally an end-stage fibrosis phase after the third week. Viral RNA and proteins were detected in pneumocytes and macrophages in a very early stage of the disease, and were no longer detected after the second week.
LIMITATION: Limited sample size.
CONCLUSIONS: The chronological evolution of COVID-19 lung histopathological lesions seems to be similar to that seen in other forms of ARDS. In particular, lung lesions consistent with potentially corticosteroid-sensitive lesions are seen.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:45 |
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| Enthalten in: |
Medicina intensiva - 45(2021), 5 vom: 01. Juni, Seite 261-270 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Merdji, H [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 10.06.2021 Date Revised 10.06.2021 published: Print Citation Status MEDLINE |
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| doi: |
10.1016/j.medine.2021.02.005 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM326078347 |
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| 100 | 1 | |a Merdji, H |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Histopathological features in fatal COVID-19 acute respiratory distress syndrome |
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| 500 | |a Date Completed 10.06.2021 | ||
| 500 | |a Date Revised 10.06.2021 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2021 Elsevier España, S.L.U. and SEMICYUC. All rights reserved. | ||
| 520 | |a BACKGROUND: COVID-19 acute respiratory distress syndrome (ARDS) shares the common histological hallmarks with other forms of ARDS. However, the chronology of the histological lesions has not been well established | ||
| 520 | |a OBJECTIVE: To describe the chronological histopathological alterations in the lungs of patients with COVID-19 related ARDS | ||
| 520 | |a DESIGN: A prospective cohort study was carried out | ||
| 520 | |a SETTING: Intensive Care Unit of a tertiary hospital | ||
| 520 | |a PATIENTS: The first 22 consecutive COVID-19 deaths | ||
| 520 | |a MEASUREMENTS: Lung biopsies and histopathological analyses were performed in deceased patients with COVID-19 related ARDS. Clinical data and patient course were evaluated | ||
| 520 | |a RESULTS: The median patient age was 66 [63-74] years; 73% were males. The median duration of mechanical ventilation was 17 [8-24] days. COVID-19 induced pulmonary injury was characterized by an exudative phase in the first week of the disease, followed by a proliferative/organizing phase in the second and third weeks, and finally an end-stage fibrosis phase after the third week. Viral RNA and proteins were detected in pneumocytes and macrophages in a very early stage of the disease, and were no longer detected after the second week | ||
| 520 | |a LIMITATION: Limited sample size | ||
| 520 | |a CONCLUSIONS: The chronological evolution of COVID-19 lung histopathological lesions seems to be similar to that seen in other forms of ARDS. In particular, lung lesions consistent with potentially corticosteroid-sensitive lesions are seen | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a COVID-19 | |
| 650 | 4 | |a COVID-19 related acute respiratory distress syndrome | |
| 650 | 4 | |a Histopathology | |
| 650 | 4 | |a Histopatología | |
| 650 | 4 | |a SARS-CoV-2 | |
| 650 | 4 | |a Síndrome de dificultad respiratoria aguda asociada a COVID-19 | |
| 700 | 1 | |a Mayeur, S |e verfasserin |4 aut | |
| 700 | 1 | |a Schenck, M |e verfasserin |4 aut | |
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| 700 | 1 | |a Clere-Jehl, R |e verfasserin |4 aut | |
| 700 | 1 | |a Cunat, S |e verfasserin |4 aut | |
| 700 | 1 | |a Herbrecht, J-E |e verfasserin |4 aut | |
| 700 | 1 | |a Janssen-Langenstein, R |e verfasserin |4 aut | |
| 700 | 1 | |a Nicolae, A |e verfasserin |4 aut | |
| 700 | 1 | |a Helms, J |e verfasserin |4 aut | |
| 700 | 1 | |a Meziani, F |e verfasserin |4 aut | |
| 700 | 1 | |a Chenard, M-P |e verfasserin |4 aut | |
| 700 | 0 | |a CRICS TRIGGERSEP Group (Clinical Research in Intensive Care, Sepsis Trial Group for Global Evaluation, Research in Sepsis) |e verfasserin |4 aut | |
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