Triazole analogues as potential pharmacological agents : a brief review
© The Author(s) 2021..
BACKGROUND: A large number of studies have recently reported that, because of their significant biological and pharmacological properties, heterocyclic compounds and their derivatives have attracted a strong interest in medicinal chemistry. The triazole nucleus is one of the most important heterocycles which has a feature of natural products as well as medicinal agents. Heterocyclic nitrogen is abundantly present in most medicinal compounds. The derivatization of triazole ring is based on the phenomenon of bio-isosteres in which substituted the oxygen atom of oxadiazole nucleus with nitrogen triazole analogue.
MAIN TEXT: This review focuses on recent synthetic procedure of triazole moiety, which comprises of various pharmacological activities such as antimicrobial, anticonvulsant, anti-inflammatory, analgesic, antitubercular, anthelmintic, antioxidant, antimalarial, antiviral, etc.
CONCLUSION: This review highlights the current status of triazole compounds as different multi-target pharmacological activities. From the literature survey, triazole is the most widely used compound in different potential activities.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2021 |
|---|---|
| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:7 |
|---|---|
| Enthalten in: |
Future journal of pharmaceutical sciences - 7(2021), 1 vom: 29., Seite 106 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Kumar, Sachin [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Analgesic |
|---|
| Anmerkungen: |
Date Revised 23.04.2022 published: Print-Electronic Citation Status PubMed-not-MEDLINE |
|---|
| doi: |
10.1186/s43094-021-00241-3 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM326046526 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM326046526 | ||
| 003 | DE-627 | ||
| 005 | 20231225193737.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231225s2021 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1186/s43094-021-00241-3 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1086.xml |
| 035 | |a (DE-627)NLM326046526 | ||
| 035 | |a (NLM)34056014 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Kumar, Sachin |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Triazole analogues as potential pharmacological agents |b a brief review |
| 264 | 1 | |c 2021 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Revised 23.04.2022 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a © The Author(s) 2021. | ||
| 520 | |a BACKGROUND: A large number of studies have recently reported that, because of their significant biological and pharmacological properties, heterocyclic compounds and their derivatives have attracted a strong interest in medicinal chemistry. The triazole nucleus is one of the most important heterocycles which has a feature of natural products as well as medicinal agents. Heterocyclic nitrogen is abundantly present in most medicinal compounds. The derivatization of triazole ring is based on the phenomenon of bio-isosteres in which substituted the oxygen atom of oxadiazole nucleus with nitrogen triazole analogue | ||
| 520 | |a MAIN TEXT: This review focuses on recent synthetic procedure of triazole moiety, which comprises of various pharmacological activities such as antimicrobial, anticonvulsant, anti-inflammatory, analgesic, antitubercular, anthelmintic, antioxidant, antimalarial, antiviral, etc | ||
| 520 | |a CONCLUSION: This review highlights the current status of triazole compounds as different multi-target pharmacological activities. From the literature survey, triazole is the most widely used compound in different potential activities | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Review | |
| 650 | 4 | |a Analgesic | |
| 650 | 4 | |a Anthelmintic | |
| 650 | 4 | |a Anti-inflammatory | |
| 650 | 4 | |a Antimicrobial | |
| 650 | 4 | |a Triazole | |
| 700 | 1 | |a Khokra, Sukhbir Lal |e verfasserin |4 aut | |
| 700 | 1 | |a Yadav, Akash |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Future journal of pharmaceutical sciences |d 2020 |g 7(2021), 1 vom: 29., Seite 106 |w (DE-627)NLM317821245 |x 2314-7253 |7 nnns |
| 773 | 1 | 8 | |g volume:7 |g year:2021 |g number:1 |g day:29 |g pages:106 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1186/s43094-021-00241-3 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 7 |j 2021 |e 1 |b 29 |h 106 | ||