Antioxidants and/or fish oil reduce intermittent hypoxia-induced inflammation in the neonatal rat terminal ileum
Copyright © 2021 Elsevier Inc. All rights reserved..
Intermittent hypoxia (IH) is associated with the pathogenesis of necrotizing enterocolitis (NEC). We tested the hypothesis that early supplementation with antioxidants and/or fish oil protects the terminal ileum from oxidative injury induced by neonatal IH. Newborn rats were exposed to neonatal IH from birth (P0) until P14 during which they received daily fish oil, coenzyme Q10 (CoQ10), glutathione nanoparticles (nGSH), fish oil + CoQ10, or olive oil. Pups were then placed in room air from P14 to P21 with no further supplementation. Terminal ileum was assessed for IH-induced injury and inflammatory biomarkers. Neonatal IH induced severe damage consistent with NEC, and was associated with oxidative stress and elevations in PGE2, PGF2α, TxB2, NOS-2 and TLR-4, effects that were ameliorated with nGSH and combination CoQ10+fish oil. Early postnatal supplementation with antioxidants and/or fish oil during neonatal IH may be favorable for preserving gut integrity and reducing oxidative injury.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2021 |
|---|---|
| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:155 |
|---|---|
| Enthalten in: |
Prostaglandins & other lipid mediators - 155(2021) vom: 01. Aug., Seite 106565 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Mustafa, Ghassan [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Coenzyme Q10 |
|---|
| Anmerkungen: |
Date Completed 28.01.2022 Date Revised 28.01.2022 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1016/j.prostaglandins.2021.106565 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM326000259 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM326000259 | ||
| 003 | DE-627 | ||
| 005 | 20231225193637.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231225s2021 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.prostaglandins.2021.106565 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1086.xml |
| 035 | |a (DE-627)NLM326000259 | ||
| 035 | |a (NLM)34051366 | ||
| 035 | |a (PII)S1098-8823(21)00040-X | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Mustafa, Ghassan |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Antioxidants and/or fish oil reduce intermittent hypoxia-induced inflammation in the neonatal rat terminal ileum |
| 264 | 1 | |c 2021 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 28.01.2022 | ||
| 500 | |a Date Revised 28.01.2022 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2021 Elsevier Inc. All rights reserved. | ||
| 520 | |a Intermittent hypoxia (IH) is associated with the pathogenesis of necrotizing enterocolitis (NEC). We tested the hypothesis that early supplementation with antioxidants and/or fish oil protects the terminal ileum from oxidative injury induced by neonatal IH. Newborn rats were exposed to neonatal IH from birth (P0) until P14 during which they received daily fish oil, coenzyme Q10 (CoQ10), glutathione nanoparticles (nGSH), fish oil + CoQ10, or olive oil. Pups were then placed in room air from P14 to P21 with no further supplementation. Terminal ileum was assessed for IH-induced injury and inflammatory biomarkers. Neonatal IH induced severe damage consistent with NEC, and was associated with oxidative stress and elevations in PGE2, PGF2α, TxB2, NOS-2 and TLR-4, effects that were ameliorated with nGSH and combination CoQ10+fish oil. Early postnatal supplementation with antioxidants and/or fish oil during neonatal IH may be favorable for preserving gut integrity and reducing oxidative injury | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, N.I.H., Extramural | |
| 650 | 4 | |a Coenzyme Q10 | |
| 650 | 4 | |a Fish oil | |
| 650 | 4 | |a Glutathione nanoparticles | |
| 650 | 4 | |a Neonatal intermittent hypoxia | |
| 650 | 4 | |a Prostanoids | |
| 650 | 4 | |a Terminal ileum | |
| 650 | 7 | |a Fish Oils |2 NLM | |
| 700 | 1 | |a Cai, Charles L |e verfasserin |4 aut | |
| 700 | 1 | |a Bodkin, Darren |e verfasserin |4 aut | |
| 700 | 1 | |a Aranda, Jacob V |e verfasserin |4 aut | |
| 700 | 1 | |a Beharry, Kay D |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Prostaglandins & other lipid mediators |d 1998 |g 155(2021) vom: 01. Aug., Seite 106565 |w (DE-627)NLM095840443 |x 1098-8823 |7 nnns |
| 773 | 1 | 8 | |g volume:155 |g year:2021 |g day:01 |g month:08 |g pages:106565 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1016/j.prostaglandins.2021.106565 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 155 |j 2021 |b 01 |c 08 |h 106565 | ||