Dietary vitamin D intake and colorectal cancer risk : a longitudinal approach within the PREDIMED study
© 2021. Springer-Verlag GmbH Germany, part of Springer Nature..
PURPOSE: We evaluated whether the intake of dietary vitamin D is associated with the incidence of both colorectal cancer (CRC) and colon cancer in the framework of the PREDIMED cohort of older adults at high cardiovascular risk.
METHODS: We analyzed data from 7216 men and women (55-80 years) without CRC at baseline from the PREvención con DIeta MEDiterránea study. Baseline consumption of vitamin D was assessed using a validated 137-item food frequency questionnaire. Cox proportional hazards ratios (HRs) of CRC and colon cancer incidence were estimated for quartiles and per 1-SD of baseline vitamin D intake.
RESULTS: During a median follow-up of 6 years, we documented 97 incident CRC cases after the exclusion of subjects with no baseline dietary data and/or outliers of energy intake. A non-significant HRs and 95% confidence intervals (CIs) of CRC for the comparison of extreme quartiles (4th vs 1st) of vitamin D intake were observed [0.55 (0.30-1.00), P for trend = 0.072], whereas it was significant for colon cancer incidence alone [0.44 (0.22-0.90), P for trend = 0.032]. However, this association became significant in CRC and colon cancer incidence, after excluding 391 subjects consuming baseline vitamin D and/or calcium medication or prescribed supplements [0.52 (0.28-0.96) and 0.41 (0.12-0.85), respectively].
CONCLUSION: A higher dietary intake of vitamin D was significantly associated with a reduced CRC risk in individuals at high cardiovascular risk.
Medienart: |
E-Artikel |
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Erscheinungsjahr: |
2021 |
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Erschienen: |
2021 |
Enthalten in: |
Zur Gesamtaufnahme - volume:60 |
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Enthalten in: |
European journal of nutrition - 60(2021), 8 vom: 17. Dez., Seite 4367-4378 |
Sprache: |
Englisch |
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Beteiligte Personen: |
Hernández-Alonso, Pablo [VerfasserIn] |
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Links: |
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Themen: |
1406-16-2 |
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Anmerkungen: |
Date Completed 09.11.2021 Date Revised 09.11.2021 published: Print-Electronic Citation Status MEDLINE |
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doi: |
10.1007/s00394-021-02585-1 |
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funding: |
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Förderinstitution / Projekttitel: |
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PPN (Katalog-ID): |
NLM325990611 |
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520 | |a © 2021. Springer-Verlag GmbH Germany, part of Springer Nature. | ||
520 | |a PURPOSE: We evaluated whether the intake of dietary vitamin D is associated with the incidence of both colorectal cancer (CRC) and colon cancer in the framework of the PREDIMED cohort of older adults at high cardiovascular risk | ||
520 | |a METHODS: We analyzed data from 7216 men and women (55-80 years) without CRC at baseline from the PREvención con DIeta MEDiterránea study. Baseline consumption of vitamin D was assessed using a validated 137-item food frequency questionnaire. Cox proportional hazards ratios (HRs) of CRC and colon cancer incidence were estimated for quartiles and per 1-SD of baseline vitamin D intake | ||
520 | |a RESULTS: During a median follow-up of 6 years, we documented 97 incident CRC cases after the exclusion of subjects with no baseline dietary data and/or outliers of energy intake. A non-significant HRs and 95% confidence intervals (CIs) of CRC for the comparison of extreme quartiles (4th vs 1st) of vitamin D intake were observed [0.55 (0.30-1.00), P for trend = 0.072], whereas it was significant for colon cancer incidence alone [0.44 (0.22-0.90), P for trend = 0.032]. However, this association became significant in CRC and colon cancer incidence, after excluding 391 subjects consuming baseline vitamin D and/or calcium medication or prescribed supplements [0.52 (0.28-0.96) and 0.41 (0.12-0.85), respectively] | ||
520 | |a CONCLUSION: A higher dietary intake of vitamin D was significantly associated with a reduced CRC risk in individuals at high cardiovascular risk | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a Cancer | |
650 | 4 | |a Colorectal cancer | |
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700 | 1 | |a Toledo, Estefanía |e verfasserin |4 aut | |
700 | 1 | |a Sorlí, Jose V |e verfasserin |4 aut | |
700 | 1 | |a Estruch, Ramón |e verfasserin |4 aut | |
700 | 1 | |a Castañer, Olga |e verfasserin |4 aut | |
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