Primary Versus Secondary Radiotherapy for Heterotopic Ossification Prevention About the Elbow
Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved..
OBJECTIVES: To examine the efficacy and safety of radiotherapy for the prevention of heterotopic ossification (HO) about the elbow.
DESIGN: Retrospective chart review.
SETTING: Level 1 trauma center.
PATIENTS/PARTICIPANTS: Two hundred and twenty-nine patients who received prophylactic radiotherapy (XRT) over a 15-year period were identified. Patients were included if they received XRT to the elbow joint and had at least 12 weeks of follow-up after XRT. Fifty-four patients were ultimately included.
INTERVENTION: All patients were treated with a single dose of 7 Gy. Ninety-eight percentage of patients received XRT within 24 hours after surgery, and all patients received XRT within 72 hours after surgery.
MAIN OUTCOMES MEASUREMENTS: The primary study measures evaluated were the presence or absence of clinically symptomatic HO and the presence of radiographic HO after XRT to the elbow joint.
RESULTS: Eighteen patients were treated with XRT after a traumatic injury requiring surgery (primary prophylaxis), and 36 were treated with XRT after excision surgery to remove HO which had already formed (secondary prophylaxis). In the primary cohort, 16.7% developed symptomatic HO after XRT and 11.1% required surgery to resect the heterotopic bone. In the secondary cohort, 11.1% developed symptomatic HO after surgery and XRT and 5.5% required resection surgery. No secondary malignancies were identified.
CONCLUSIONS: Our findings suggest that XRT for elbow HO may be safe and effective for both primary and secondary HO. XRT for HO was not shown to be associated with radiation-induced sarcoma in this series, at least in the short term. Further study in a large patient population with extended follow-up is required to better characterize populations at high risk for development of HO and secondary malignancy.
LEVEL OF EVIDENCE: Prognostic Level III. See Instructions for Authors for a complete description of levels of evidence.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2022 |
|---|---|
| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:36 |
|---|---|
| Enthalten in: |
Journal of orthopaedic trauma - 36(2022), 2 vom: 01. Feb., Seite e56-e61 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Geller, Joseph S [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
|---|
| Anmerkungen: |
Date Completed 27.01.2022 Date Revised 28.08.2023 published: Print Citation Status MEDLINE |
|---|
| doi: |
10.1097/BOT.0000000000002188 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM325987890 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM325987890 | ||
| 003 | DE-627 | ||
| 005 | 20231225193620.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231225s2022 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1097/BOT.0000000000002188 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1086.xml |
| 035 | |a (DE-627)NLM325987890 | ||
| 035 | |a (NLM)34050084 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Geller, Joseph S |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Primary Versus Secondary Radiotherapy for Heterotopic Ossification Prevention About the Elbow |
| 264 | 1 | |c 2022 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 27.01.2022 | ||
| 500 | |a Date Revised 28.08.2023 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved. | ||
| 520 | |a OBJECTIVES: To examine the efficacy and safety of radiotherapy for the prevention of heterotopic ossification (HO) about the elbow | ||
| 520 | |a DESIGN: Retrospective chart review | ||
| 520 | |a SETTING: Level 1 trauma center | ||
| 520 | |a PATIENTS/PARTICIPANTS: Two hundred and twenty-nine patients who received prophylactic radiotherapy (XRT) over a 15-year period were identified. Patients were included if they received XRT to the elbow joint and had at least 12 weeks of follow-up after XRT. Fifty-four patients were ultimately included | ||
| 520 | |a INTERVENTION: All patients were treated with a single dose of 7 Gy. Ninety-eight percentage of patients received XRT within 24 hours after surgery, and all patients received XRT within 72 hours after surgery | ||
| 520 | |a MAIN OUTCOMES MEASUREMENTS: The primary study measures evaluated were the presence or absence of clinically symptomatic HO and the presence of radiographic HO after XRT to the elbow joint | ||
| 520 | |a RESULTS: Eighteen patients were treated with XRT after a traumatic injury requiring surgery (primary prophylaxis), and 36 were treated with XRT after excision surgery to remove HO which had already formed (secondary prophylaxis). In the primary cohort, 16.7% developed symptomatic HO after XRT and 11.1% required surgery to resect the heterotopic bone. In the secondary cohort, 11.1% developed symptomatic HO after surgery and XRT and 5.5% required resection surgery. No secondary malignancies were identified | ||
| 520 | |a CONCLUSIONS: Our findings suggest that XRT for elbow HO may be safe and effective for both primary and secondary HO. XRT for HO was not shown to be associated with radiation-induced sarcoma in this series, at least in the short term. Further study in a large patient population with extended follow-up is required to better characterize populations at high risk for development of HO and secondary malignancy | ||
| 520 | |a LEVEL OF EVIDENCE: Prognostic Level III. See Instructions for Authors for a complete description of levels of evidence | ||
| 650 | 4 | |a Journal Article | |
| 700 | 1 | |a Allegra, Paul R |e verfasserin |4 aut | |
| 700 | 1 | |a Seldon, Crystal S |e verfasserin |4 aut | |
| 700 | 1 | |a Spieler, Benjamin O |e verfasserin |4 aut | |
| 700 | 1 | |a Cohen, Lara L |e verfasserin |4 aut | |
| 700 | 1 | |a Barnhill, Spencer W |e verfasserin |4 aut | |
| 700 | 1 | |a Huntley, Samuel R |e verfasserin |4 aut | |
| 700 | 1 | |a De La Zerda, Alberto |e verfasserin |4 aut | |
| 700 | 1 | |a Samuels, Stuart |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Lora |e verfasserin |4 aut | |
| 700 | 1 | |a Isrow, Derek |e verfasserin |4 aut | |
| 700 | 1 | |a Wolfson, Aaron H |e verfasserin |4 aut | |
| 700 | 1 | |a Yechieli, Raphael L |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Journal of orthopaedic trauma |d 1996 |g 36(2022), 2 vom: 01. Feb., Seite e56-e61 |w (DE-627)NLM012994979 |x 1531-2291 |7 nnns |
| 773 | 1 | 8 | |g volume:36 |g year:2022 |g number:2 |g day:01 |g month:02 |g pages:e56-e61 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1097/BOT.0000000000002188 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 36 |j 2022 |e 2 |b 01 |c 02 |h e56-e61 | ||