Pneumothorax in critically ill patients with COVID-19 infection : Incidence, clinical characteristics and outcomes in a case control multicenter study
Copyright © 2021 Elsevier Ltd. All rights reserved..
BACKGROUND: The clinical features and outcomes of mechanically ventilated patients with COVID-19 infection who develop a pneumothorax has not been rigorously described or compared to those who do not develop a pneumothorax.
PURPOSE: To determine the incidence, clinical characteristics, and outcomes of critically ill patients with COVID-19 infection who developed pneumothorax. In addition, we compared the clinical characteristics and outcomes of mechanically ventilated patients who developed a pneumothorax with those who did not develop a pneumothorax.
METHODS: This study was a multicenter retrospective analysis of all adult critically ill patients with COVID-19 infection who were admitted to intensive care units in 4 tertiary care centers in the United States.
RESULTS: A total of 842 critically ill patients with COVID-19 infection were analyzed, out of which 594 (71%) were mechanically ventilated. The overall incidence of pneumothorax was 85/842 (10%), and 80/594 (13%) in those who were mechanically ventilated. As compared to mechanically ventilated patients in the non-pneumothorax group, mechanically ventilated patients in the pneumothorax group had worse respiratory parameters at the time of intubation (mean PaO2:FiO2 ratio 105 vs 150, P<0.001 and static respiratory system compliance: 30ml/cmH2O vs 39ml/cmH2O, P = 0.01) and significantly higher in-hospital mortality (63% vs 49%, P = 0.04).
CONCLUSION: The overall incidence of pneumothorax in mechanically ventilated patients with COVID-19 infection was 13%. Mechanically ventilated patients with COVID-19 infection who developed pneumothorax had worse gas exchange and respiratory mechanics at the time of intubation and had a higher mortality compared to those who did not develop pneumothorax.
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:184 |
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| Enthalten in: |
Respiratory medicine - 184(2021) vom: 01. Aug., Seite 106464 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Chopra, Amit [VerfasserIn] |
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| Links: |
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| Themen: |
2 |
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Date Completed 14.07.2021 Date Revised 21.12.2022 published: Print-Electronic CommentIn: Respir Med. 2021 Oct;187:106552. - PMID 34364198 Citation Status MEDLINE |
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| doi: |
10.1016/j.rmed.2021.106464 |
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| PPN (Katalog-ID): |
NLM325930287 |
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| 100 | 1 | |a Chopra, Amit |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Pneumothorax in critically ill patients with COVID-19 infection |b Incidence, clinical characteristics and outcomes in a case control multicenter study |
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| 500 | |a Date Completed 14.07.2021 | ||
| 500 | |a Date Revised 21.12.2022 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a CommentIn: Respir Med. 2021 Oct;187:106552. - PMID 34364198 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2021 Elsevier Ltd. All rights reserved. | ||
| 520 | |a BACKGROUND: The clinical features and outcomes of mechanically ventilated patients with COVID-19 infection who develop a pneumothorax has not been rigorously described or compared to those who do not develop a pneumothorax | ||
| 520 | |a PURPOSE: To determine the incidence, clinical characteristics, and outcomes of critically ill patients with COVID-19 infection who developed pneumothorax. In addition, we compared the clinical characteristics and outcomes of mechanically ventilated patients who developed a pneumothorax with those who did not develop a pneumothorax | ||
| 520 | |a METHODS: This study was a multicenter retrospective analysis of all adult critically ill patients with COVID-19 infection who were admitted to intensive care units in 4 tertiary care centers in the United States | ||
| 520 | |a RESULTS: A total of 842 critically ill patients with COVID-19 infection were analyzed, out of which 594 (71%) were mechanically ventilated. The overall incidence of pneumothorax was 85/842 (10%), and 80/594 (13%) in those who were mechanically ventilated. As compared to mechanically ventilated patients in the non-pneumothorax group, mechanically ventilated patients in the pneumothorax group had worse respiratory parameters at the time of intubation (mean PaO2:FiO2 ratio 105 vs 150, P<0.001 and static respiratory system compliance: 30ml/cmH2O vs 39ml/cmH2O, P = 0.01) and significantly higher in-hospital mortality (63% vs 49%, P = 0.04) | ||
| 520 | |a CONCLUSION: The overall incidence of pneumothorax in mechanically ventilated patients with COVID-19 infection was 13%. Mechanically ventilated patients with COVID-19 infection who developed pneumothorax had worse gas exchange and respiratory mechanics at the time of intubation and had a higher mortality compared to those who did not develop pneumothorax | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a 2 | |
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| 650 | 4 | |a COVID-19 | |
| 650 | 4 | |a Coronavirus disease 2019 | |
| 650 | 4 | |a Incidence | |
| 650 | 4 | |a Mortality | |
| 650 | 4 | |a Pneumomediastinum | |
| 650 | 4 | |a Pneumothorax | |
| 650 | 4 | |a SARS-CoV-2 | |
| 700 | 1 | |a Al-Tarbsheh, Ali Hani |e verfasserin |4 aut | |
| 700 | 1 | |a Shah, Nidhi J |e verfasserin |4 aut | |
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| 700 | 1 | |a Conuel, Edward |e verfasserin |4 aut | |
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