Amygdala dynorphin/κ opioid receptor system modulates depressive-like behavior in mice following chronic social defeat stress
© 2021. The Author(s), under exclusive licence to CPS and SIMM..
Major depression disorder is a severe and recurrent neuropsychological disorder characterized by lowered mood and social activity and cognitive impairment. Owing to unclear molecular mechanisms of depression, limited interventions are available in clinic. In this study we investigated the role of dynorphin/κ opioid receptor system in the development of depression. Mice were subjected to chronic social defeat stress for 14 days. Chronic social defeat stress induced significant social avoidance in mice characterized by decreased time duration in the interaction zone and increased time duration in the corner zone. Pre-administration of a κ opioid receptor antagonist norBNI (10 mg/kg, i.p.) could prevent the development of social avoidance induced by chronic social defeat stress. Social avoidance was not observed in κ opioid receptor knockout mice subjected to chronic social defeat stress. We further revealed that social defeat stress activated c-fos and ERK signaling in the amygdala without affecting the NAc, hippocampus and hypothalamus, and ERK activation was blocked by systemic injection of norBNI. Finally, the expression of dynorphin A, the endogenous ligand of κ opioid receptor, was significantly increased in the amygdala following social defeat stress; microinjection of norBNI into the amygdala prevented the development of depressive-like behaviors caused by social defeat stress. The present study demonstrates that upregulated dynorphin/κ opioid receptor system in the amygdala leads to the emergence of depression following chronic social defeat stress, and sheds light on κ opioid receptor antagonists as potential therapeutic agents for the prevention and treatment of depression following chronic stress.
| Errataetall: |
ErratumIn: Acta Pharmacol Sin. 2023 May;44(5):1107-1108. - PMID 36400838 |
|---|---|
| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2022 |
|---|---|
| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:43 |
|---|---|
| Enthalten in: |
Acta pharmacologica Sinica - 43(2022), 3 vom: 25. März, Seite 577-587 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Zan, Gui-Ying [VerfasserIn] |
|---|
| Links: |
|---|
| Anmerkungen: |
Date Completed 23.03.2022 Date Revised 02.03.2023 published: Print-Electronic ErratumIn: Acta Pharmacol Sin. 2023 May;44(5):1107-1108. - PMID 36400838 Citation Status MEDLINE |
|---|
| doi: |
10.1038/s41401-021-00677-6 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM325845077 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM325845077 | ||
| 003 | DE-627 | ||
| 005 | 20231225193316.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231225s2022 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1038/s41401-021-00677-6 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1086.xml |
| 035 | |a (DE-627)NLM325845077 | ||
| 035 | |a (NLM)34035484 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Zan, Gui-Ying |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Amygdala dynorphin/κ opioid receptor system modulates depressive-like behavior in mice following chronic social defeat stress |
| 264 | 1 | |c 2022 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 23.03.2022 | ||
| 500 | |a Date Revised 02.03.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a ErratumIn: Acta Pharmacol Sin. 2023 May;44(5):1107-1108. - PMID 36400838 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2021. The Author(s), under exclusive licence to CPS and SIMM. | ||
| 520 | |a Major depression disorder is a severe and recurrent neuropsychological disorder characterized by lowered mood and social activity and cognitive impairment. Owing to unclear molecular mechanisms of depression, limited interventions are available in clinic. In this study we investigated the role of dynorphin/κ opioid receptor system in the development of depression. Mice were subjected to chronic social defeat stress for 14 days. Chronic social defeat stress induced significant social avoidance in mice characterized by decreased time duration in the interaction zone and increased time duration in the corner zone. Pre-administration of a κ opioid receptor antagonist norBNI (10 mg/kg, i.p.) could prevent the development of social avoidance induced by chronic social defeat stress. Social avoidance was not observed in κ opioid receptor knockout mice subjected to chronic social defeat stress. We further revealed that social defeat stress activated c-fos and ERK signaling in the amygdala without affecting the NAc, hippocampus and hypothalamus, and ERK activation was blocked by systemic injection of norBNI. Finally, the expression of dynorphin A, the endogenous ligand of κ opioid receptor, was significantly increased in the amygdala following social defeat stress; microinjection of norBNI into the amygdala prevented the development of depressive-like behaviors caused by social defeat stress. The present study demonstrates that upregulated dynorphin/κ opioid receptor system in the amygdala leads to the emergence of depression following chronic social defeat stress, and sheds light on κ opioid receptor antagonists as potential therapeutic agents for the prevention and treatment of depression following chronic stress | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a ERK | |
| 650 | 4 | |a amygdala | |
| 650 | 4 | |a c-fos | |
| 650 | 4 | |a depression | |
| 650 | 4 | |a dynorphin | |
| 650 | 4 | |a norBNI | |
| 650 | 4 | |a social defeat stress | |
| 650 | 4 | |a κ opioid receptor | |
| 650 | 7 | |a Proto-Oncogene Proteins c-fos |2 NLM | |
| 650 | 7 | |a Receptors, Opioid, kappa |2 NLM | |
| 650 | 7 | |a binaltorphimine |2 NLM | |
| 650 | 7 | |a 105618-27-7 |2 NLM | |
| 650 | 7 | |a Naltrexone |2 NLM | |
| 650 | 7 | |a 5S6W795CQM |2 NLM | |
| 650 | 7 | |a Dynorphins |2 NLM | |
| 650 | 7 | |a 74913-18-1 |2 NLM | |
| 650 | 7 | |a Extracellular Signal-Regulated MAP Kinases |2 NLM | |
| 650 | 7 | |a EC 2.7.11.24 |2 NLM | |
| 700 | 1 | |a Sun, Xiang |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Yu-Jun |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Rui |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Chen-Yao |e verfasserin |4 aut | |
| 700 | 1 | |a Du, Wei-Jia |e verfasserin |4 aut | |
| 700 | 1 | |a Guo, Liu-Bin |e verfasserin |4 aut | |
| 700 | 1 | |a Chai, Jing-Rui |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Qing-Lin |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Zhi-Qiang |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Jing-Gen |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Acta pharmacologica Sinica |d 2000 |g 43(2022), 3 vom: 25. März, Seite 577-587 |w (DE-627)NLM111735181 |x 1745-7254 |7 nnns |
| 773 | 1 | 8 | |g volume:43 |g year:2022 |g number:3 |g day:25 |g month:03 |g pages:577-587 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1038/s41401-021-00677-6 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 43 |j 2022 |e 3 |b 25 |c 03 |h 577-587 | ||