Preemptive effects of ibuprofen and nimesulide on postoperative pain control after open flap periodontal surgeries : A randomized placebo-controlled split-mouth clinical trial
© 2021 American Academy of Periodontology..
BACKGROUND: Data on preemptive analgesia in periodontal surgeries are scarce and still diverse. The aim of this study was to evaluate and compare the analgesic effects of the preemptive administration of ibuprofen and nimesulide in open flap periodontal surgeries.
METHODS: The present randomized controlled clinical trial comprised 40 individuals, divided into two groups (n = 20), according to the test drug (ibuprofen and nimesulide) to be administered 1 hour preoperatively. Participants underwent bilateral periodontal surgeries at two different times, and were randomly given the test drug or placebo in a split-mouth design. Postoperative pain and rescue medication were evaluated at different times. Comparisons between ibuprofen and nimesulide were performed through a Generalized Estimation Equation model, using test drug and evaluation times, along with an interaction between these two variables as predictors.
RESULTS: In intergroup comparisons regarding pain control, ibuprofen showed better effects than placebo only at the first postoperative hour, whereas nimesulide showed better effects than placebo at 1, 6, 24, and 48 postoperative hours. In intergroup comparisons, nimesulide showed better effects than ibuprofen at 24, 48, and 72 postoperative hours, demonstrating a higher overall preemptive effect. No differences were observed in relation to the number of rescue medication.
CONCLUSION: Preemptive administration of nimesulide showed better overall preemptive effects on postoperative pain control when compared with ibuprofen.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2022 |
|---|---|
| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:93 |
|---|---|
| Enthalten in: |
Journal of periodontology - 93(2022), 2 vom: 15. Feb., Seite 298-307 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Santos, Bianca F E [VerfasserIn] |
|---|
| Links: |
|---|
| Anmerkungen: |
Date Completed 02.05.2022 Date Revised 02.05.2022 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1002/JPER.20-0887 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM325810885 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM325810885 | ||
| 003 | DE-627 | ||
| 005 | 20231225193228.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231225s2022 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1002/JPER.20-0887 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1085.xml |
| 035 | |a (DE-627)NLM325810885 | ||
| 035 | |a (NLM)34031888 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Santos, Bianca F E |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Preemptive effects of ibuprofen and nimesulide on postoperative pain control after open flap periodontal surgeries |b A randomized placebo-controlled split-mouth clinical trial |
| 264 | 1 | |c 2022 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 02.05.2022 | ||
| 500 | |a Date Revised 02.05.2022 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2021 American Academy of Periodontology. | ||
| 520 | |a BACKGROUND: Data on preemptive analgesia in periodontal surgeries are scarce and still diverse. The aim of this study was to evaluate and compare the analgesic effects of the preemptive administration of ibuprofen and nimesulide in open flap periodontal surgeries | ||
| 520 | |a METHODS: The present randomized controlled clinical trial comprised 40 individuals, divided into two groups (n = 20), according to the test drug (ibuprofen and nimesulide) to be administered 1 hour preoperatively. Participants underwent bilateral periodontal surgeries at two different times, and were randomly given the test drug or placebo in a split-mouth design. Postoperative pain and rescue medication were evaluated at different times. Comparisons between ibuprofen and nimesulide were performed through a Generalized Estimation Equation model, using test drug and evaluation times, along with an interaction between these two variables as predictors | ||
| 520 | |a RESULTS: In intergroup comparisons regarding pain control, ibuprofen showed better effects than placebo only at the first postoperative hour, whereas nimesulide showed better effects than placebo at 1, 6, 24, and 48 postoperative hours. In intergroup comparisons, nimesulide showed better effects than ibuprofen at 24, 48, and 72 postoperative hours, demonstrating a higher overall preemptive effect. No differences were observed in relation to the number of rescue medication | ||
| 520 | |a CONCLUSION: Preemptive administration of nimesulide showed better overall preemptive effects on postoperative pain control when compared with ibuprofen | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Randomized Controlled Trial | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a analgesia; ibuprofen; nimesulide; pain | |
| 650 | 4 | |a postoperative; pain management; preanesthetic medication | |
| 650 | 7 | |a Sulfonamides |2 NLM | |
| 650 | 7 | |a nimesulide |2 NLM | |
| 650 | 7 | |a V4TKW1454M |2 NLM | |
| 650 | 7 | |a Ibuprofen |2 NLM | |
| 650 | 7 | |a WK2XYI10QM |2 NLM | |
| 700 | 1 | |a Costa, Fernando O |e verfasserin |4 aut | |
| 700 | 1 | |a Vasconcelos, Andrea M A |e verfasserin |4 aut | |
| 700 | 1 | |a Cyrino, Renata M |e verfasserin |4 aut | |
| 700 | 1 | |a Cota, Luís O M |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Journal of periodontology |d 1970 |g 93(2022), 2 vom: 15. Feb., Seite 298-307 |w (DE-627)NLM000139386 |x 1943-3670 |7 nnns |
| 773 | 1 | 8 | |g volume:93 |g year:2022 |g number:2 |g day:15 |g month:02 |g pages:298-307 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1002/JPER.20-0887 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 93 |j 2022 |e 2 |b 15 |c 02 |h 298-307 | ||