Adhesion-mediated mechanosignaling forces mitohormesis
Published by Elsevier Inc..
Mitochondria control eukaryotic cell fate by producing the energy needed to support life and the signals required to execute programed cell death. The biochemical milieu is known to affect mitochondrial function and contribute to the dysfunctional mitochondrial phenotypes implicated in cancer and the morbidities of aging. However, the physical characteristics of the extracellular matrix are also altered in cancerous and aging tissues. Here, we demonstrate that cells sense the physical properties of the extracellular matrix and activate a mitochondrial stress response that adaptively tunes mitochondrial function via solute carrier family 9 member A1-dependent ion exchange and heat shock factor 1-dependent transcription. Overall, our data indicate that adhesion-mediated mechanosignaling may play an unappreciated role in the altered mitochondrial functions observed in aging and cancer.
| Errataetall: |
CommentIn: Curr Biol. 2021 Jul 12;31(13):R859-R861. - PMID 34256921 |
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:33 |
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| Enthalten in: |
Cell metabolism - 33(2021), 7 vom: 06. Juli, Seite 1322-1341.e13 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Tharp, Kevin M [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 30.03.2022 Date Revised 14.10.2022 published: Print-Electronic CommentIn: Curr Biol. 2021 Jul 12;31(13):R859-R861. - PMID 34256921 Citation Status MEDLINE |
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| doi: |
10.1016/j.cmet.2021.04.017 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 500 | |a CommentIn: Curr Biol. 2021 Jul 12;31(13):R859-R861. - PMID 34256921 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Published by Elsevier Inc. | ||
| 520 | |a Mitochondria control eukaryotic cell fate by producing the energy needed to support life and the signals required to execute programed cell death. The biochemical milieu is known to affect mitochondrial function and contribute to the dysfunctional mitochondrial phenotypes implicated in cancer and the morbidities of aging. However, the physical characteristics of the extracellular matrix are also altered in cancerous and aging tissues. Here, we demonstrate that cells sense the physical properties of the extracellular matrix and activate a mitochondrial stress response that adaptively tunes mitochondrial function via solute carrier family 9 member A1-dependent ion exchange and heat shock factor 1-dependent transcription. Overall, our data indicate that adhesion-mediated mechanosignaling may play an unappreciated role in the altered mitochondrial functions observed in aging and cancer | ||
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| 700 | 1 | |a Timblin, Greg A |e verfasserin |4 aut | |
| 700 | 1 | |a Ford, Breanna |e verfasserin |4 aut | |
| 700 | 1 | |a Garzon-Coral, Carlos |e verfasserin |4 aut | |
| 700 | 1 | |a Schneider, Catherine |e verfasserin |4 aut | |
| 700 | 1 | |a Muncie, Jonathon M |e verfasserin |4 aut | |
| 700 | 1 | |a Stashko, Connor |e verfasserin |4 aut | |
| 700 | 1 | |a Daniele, Joseph R |e verfasserin |4 aut | |
| 700 | 1 | |a Moore, Andrew S |e verfasserin |4 aut | |
| 700 | 1 | |a Frankino, Phillip A |e verfasserin |4 aut | |
| 700 | 1 | |a Homentcovschi, Stefan |e verfasserin |4 aut | |
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| 700 | 1 | |a Ku, Gregory M |e verfasserin |4 aut | |
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