Consensus Recommendations for the Diagnosis of Vitreoretinal Lymphoma
PURPOSE: To provide recommendations for diagnosis of vitreoretinal lymphoma (VRL).
METHODS: Literature was reviewed for reports supporting the diagnosis of VRL. A questionnaire (Delphi 1 round) was distributed to 28 participants. In the second round (Delphi 2), items of the questionnaire not reaching consensus (75% agreement) were discussed to finalize the recommendations.
RESULTS: Presenting symptoms include floaters and painless loss of vision, vitreous cells organized into sheets or clumps. Retinal lesions are usually multifocal creamy/white in the outer retina. Other findings include retinal lesions with "leopard-skin" appearance and retinal pigment epithelium atrophy. Severe vitreous infiltration without macular edema is the most likely presentation. Diagnostic vitrectomy should be performed. Systemic corticosteroid should be discontinued at least 2 weeks before surgery. An interleukin (IL)-10:IL-6 ratio > 1, positive mutation for the myeloid differentiation primary response 88 gene and monoclonality are indicators of VRL. Multi-modal imaging (optical coherence tomography, fundus autofluorescence) are recommended.
CONCLUSIONS: A consensus meeting allowed the establishment of recommendations important for the diagnosis of VRL.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:29 |
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| Enthalten in: |
Ocular immunology and inflammation - 29(2021), 3 vom: 03. Apr., Seite 507-520 |
| Sprache: |
Englisch |
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| Links: |
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| Anmerkungen: |
Date Completed 21.01.2022 Date Revised 25.04.2022 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1080/09273948.2021.1878233 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM325588864 |
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| 245 | 1 | 0 | |a Consensus Recommendations for the Diagnosis of Vitreoretinal Lymphoma |
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| 500 | |a Date Completed 21.01.2022 | ||
| 500 | |a Date Revised 25.04.2022 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a PURPOSE: To provide recommendations for diagnosis of vitreoretinal lymphoma (VRL) | ||
| 520 | |a METHODS: Literature was reviewed for reports supporting the diagnosis of VRL. A questionnaire (Delphi 1 round) was distributed to 28 participants. In the second round (Delphi 2), items of the questionnaire not reaching consensus (75% agreement) were discussed to finalize the recommendations | ||
| 520 | |a RESULTS: Presenting symptoms include floaters and painless loss of vision, vitreous cells organized into sheets or clumps. Retinal lesions are usually multifocal creamy/white in the outer retina. Other findings include retinal lesions with "leopard-skin" appearance and retinal pigment epithelium atrophy. Severe vitreous infiltration without macular edema is the most likely presentation. Diagnostic vitrectomy should be performed. Systemic corticosteroid should be discontinued at least 2 weeks before surgery. An interleukin (IL)-10:IL-6 ratio > 1, positive mutation for the myeloid differentiation primary response 88 gene and monoclonality are indicators of VRL. Multi-modal imaging (optical coherence tomography, fundus autofluorescence) are recommended | ||
| 520 | |a CONCLUSIONS: A consensus meeting allowed the establishment of recommendations important for the diagnosis of VRL | ||
| 650 | 4 | |a Consensus Development Conference | |
| 650 | 4 | |a Journal Article | |
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| 700 | 1 | |a Agarwal, Mamta |e verfasserin |4 aut | |
| 700 | 1 | |a Batchelor, Tracy |e verfasserin |4 aut | |
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| 700 | 1 | |a Rosenbaum, James T |e verfasserin |4 aut | |
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