Clinical presentation, outcomes and factors associated with mortality : A prospective study from three COVID-19 referral care centres in West Africa
Copyright © 2021 The Authors. Published by Elsevier Ltd.. All rights reserved..
OBJECTIVES: The overall death toll from COVID-19 in Africa is reported to be low but there is little individual-level evidence on the severity of the disease. This study examined the clinical spectrum and outcome of patients monitored in COVID-19 care centres (CCCs) in two West-African countries.
METHODS: Burkina Faso and Guinea set up referral CCCs to hospitalise all symptomatic SARS-CoV-2 carriers, regardless of the severity of their symptoms. Data collected from hospitalised patients by November 2020 are presented.
RESULT: A total of 1,805 patients (64% men, median age 41 years) were admitted with COVID-19. Symptoms lasted for a median of 7 days (IQR 4-11). During hospitalisation, 443 (25%) had a SpO2 < 94% at least once, 237 (13%) received oxygen and 266 (15%) took corticosteroids. Mortality was 5% overall, and 1%, 5% and 14% in patients aged <40, 40-59 and ≥60 years, respectively. In multivariable analysis, the risk of death was higher in men (aOR 2.0, 95% CI 1.1; 3.6), people aged ≥60 years (aOR 2.9, 95% CI 1.7; 4.8) and those with chronic hypertension (aOR 2.1, 95% CI 1.2; 3.4).
CONCLUSION: COVID-19 is as severe in Africa as elsewhere, and there must be more vigilance for common risk factors such as older age and hypertension.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2021 |
|---|---|
| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:108 |
|---|---|
| Enthalten in: |
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases - 108(2021) vom: 14. Juli, Seite 45-52 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Jaspard, Marie [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
COVID-19 |
|---|
| Anmerkungen: |
Date Completed 19.08.2021 Date Revised 19.08.2021 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1016/j.ijid.2021.05.024 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM325516375 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM325516375 | ||
| 003 | DE-627 | ||
| 005 | 20231225192616.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231225s2021 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.ijid.2021.05.024 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1085.xml |
| 035 | |a (DE-627)NLM325516375 | ||
| 035 | |a (NLM)34000419 | ||
| 035 | |a (PII)S1201-9712(21)00425-2 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Jaspard, Marie |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Clinical presentation, outcomes and factors associated with mortality |b A prospective study from three COVID-19 referral care centres in West Africa |
| 264 | 1 | |c 2021 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 19.08.2021 | ||
| 500 | |a Date Revised 19.08.2021 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2021 The Authors. Published by Elsevier Ltd.. All rights reserved. | ||
| 520 | |a OBJECTIVES: The overall death toll from COVID-19 in Africa is reported to be low but there is little individual-level evidence on the severity of the disease. This study examined the clinical spectrum and outcome of patients monitored in COVID-19 care centres (CCCs) in two West-African countries | ||
| 520 | |a METHODS: Burkina Faso and Guinea set up referral CCCs to hospitalise all symptomatic SARS-CoV-2 carriers, regardless of the severity of their symptoms. Data collected from hospitalised patients by November 2020 are presented | ||
| 520 | |a RESULT: A total of 1,805 patients (64% men, median age 41 years) were admitted with COVID-19. Symptoms lasted for a median of 7 days (IQR 4-11). During hospitalisation, 443 (25%) had a SpO2 < 94% at least once, 237 (13%) received oxygen and 266 (15%) took corticosteroids. Mortality was 5% overall, and 1%, 5% and 14% in patients aged <40, 40-59 and ≥60 years, respectively. In multivariable analysis, the risk of death was higher in men (aOR 2.0, 95% CI 1.1; 3.6), people aged ≥60 years (aOR 2.9, 95% CI 1.7; 4.8) and those with chronic hypertension (aOR 2.1, 95% CI 1.2; 3.4) | ||
| 520 | |a CONCLUSION: COVID-19 is as severe in Africa as elsewhere, and there must be more vigilance for common risk factors such as older age and hypertension | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a COVID-19 | |
| 650 | 4 | |a Comorbidities | |
| 650 | 4 | |a Mortality | |
| 650 | 4 | |a SARS-Cov-2 | |
| 650 | 4 | |a Sub-Saharan Africa | |
| 700 | 1 | |a Sow, Mamadou Saliou |e verfasserin |4 aut | |
| 700 | 1 | |a Juchet, Sylvain |e verfasserin |4 aut | |
| 700 | 1 | |a Dienderé, Eric |e verfasserin |4 aut | |
| 700 | 1 | |a Serra, Beatrice |e verfasserin |4 aut | |
| 700 | 1 | |a Kojan, Richard |e verfasserin |4 aut | |
| 700 | 1 | |a Sivahera, Billy |e verfasserin |4 aut | |
| 700 | 1 | |a Martin, Caroline |e verfasserin |4 aut | |
| 700 | 1 | |a Kinda, Moumouni |e verfasserin |4 aut | |
| 700 | 1 | |a Lang, Hans-Joerg |e verfasserin |4 aut | |
| 700 | 1 | |a Bangaly Sako, Fodé |e verfasserin |4 aut | |
| 700 | 1 | |a Amara Traoré, Fodé |e verfasserin |4 aut | |
| 700 | 1 | |a Koumbem, Eudoxie |e verfasserin |4 aut | |
| 700 | 1 | |a Tinto, Halidou |e verfasserin |4 aut | |
| 700 | 1 | |a Sanou, Adama |e verfasserin |4 aut | |
| 700 | 1 | |a Sondo, Apoline |e verfasserin |4 aut | |
| 700 | 1 | |a Kaboré, Flavien |e verfasserin |4 aut | |
| 700 | 1 | |a Donamou, Joseph |e verfasserin |4 aut | |
| 700 | 1 | |a Guilavogui, Jean-Paul-Yassa |e verfasserin |4 aut | |
| 700 | 1 | |a Velardo, Fanny |e verfasserin |4 aut | |
| 700 | 1 | |a Bicaba, Brice |e verfasserin |4 aut | |
| 700 | 1 | |a Marcy, Olivier |e verfasserin |4 aut | |
| 700 | 1 | |a Augier, Augustin |e verfasserin |4 aut | |
| 700 | 1 | |a Sayadi, Sani |e verfasserin |4 aut | |
| 700 | 1 | |a Poda, Armel |e verfasserin |4 aut | |
| 700 | 1 | |a Keita, Sakoba |e verfasserin |4 aut | |
| 700 | 1 | |a Anglaret, Xavier |e verfasserin |4 aut | |
| 700 | 1 | |a Malvy, Denis |e verfasserin |4 aut | |
| 700 | 0 | |a COVISTA study group |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases |d 1998 |g 108(2021) vom: 14. Juli, Seite 45-52 |w (DE-627)NLM094730857 |x 1878-3511 |7 nnns |
| 773 | 1 | 8 | |g volume:108 |g year:2021 |g day:14 |g month:07 |g pages:45-52 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1016/j.ijid.2021.05.024 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 108 |j 2021 |b 14 |c 07 |h 45-52 | ||