Anti-tRNA synthetase syndrome interstitial lung disease : A single center experience
Copyright © 2021 The Author(s). Published by Elsevier Ltd.. All rights reserved..
BACKGROUND: Recognition of Anti-tRNA synthetase (ARS) related interstitial lung disease (ILD) is key to ensuring patients have prompt access to immunosuppressive therapies. The purpose of this retrospective cohort study was to identify factors that may delay recognition of ARS-ILD.
METHODS: Patients seen at Vanderbilt University Medical Center between 9/17/2017-10/31/2018 were included in this observational cohort. Clinical and laboratory features were obtained via chart abstraction. Kruskal-Wallis ANOVA, Mann-Whitney U, and Fisher's exact t tests were utilized to determine statistical significance.
RESULTS: Patients with ARS were found to have ILD in 51.9% of cases, which was comparable to the frequency of ILD in systemic sclerosis (59.5%). The severity of FVC reduction in ARS (53.2%) was comparable to diffuse cutaneous systemic sclerosis (56.8%, p = 0.48) and greater than dermatomyositis (66.9%, p = 0.005) or limited cutaneous systemic sclerosis (71.8%, p = 0.005). Frank honeycombing was seen with ARS antibodies but not other myositis autoantibodies. ARS patients were more likely to first present to a pulmonary provider in a tertiary care setting (53.6%), likely due to fewer extrapulmonary manifestations. Only 33% of ARS-ILD were anti-nuclear antibody, rheumatoid factor, or anti-cyclic citrullinated peptide positive. Patients with ARS-ILD had a two-fold longer median time to diagnosis compared to other myositis-ILD patients (11.0 months, IQR 8.5-43 months vs. 5.0 months, IQR 3.0-9.0 months, p = 0.003).
CONCLUSIONS: ARS patients without prominent extra-pulmonary manifestations are at high risk for not being recognized as having a connective tissue disease related ILD and miscategorized as usual interstitial pneumonia/idiopathic pulmonary fibrosis without comprehensive serologies.
Medienart: |
E-Artikel |
---|
Erscheinungsjahr: |
2022 |
---|---|
Erschienen: |
2022 |
Enthalten in: |
Zur Gesamtaufnahme - volume:191 |
---|---|
Enthalten in: |
Respiratory medicine - 191(2022) vom: 13. Jan., Seite 106432 |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Wilfong, Erin M [VerfasserIn] |
---|
Links: |
---|
Anmerkungen: |
Date Completed 31.03.2022 Date Revised 16.07.2022 published: Print-Electronic Citation Status MEDLINE |
---|
doi: |
10.1016/j.rmed.2021.106432 |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
NLM325455767 |
---|
LEADER | 01000naa a22002652 4500 | ||
---|---|---|---|
001 | NLM325455767 | ||
003 | DE-627 | ||
005 | 20231225192457.0 | ||
007 | cr uuu---uuuuu | ||
008 | 231225s2022 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.1016/j.rmed.2021.106432 |2 doi | |
028 | 5 | 2 | |a pubmed24n1084.xml |
035 | |a (DE-627)NLM325455767 | ||
035 | |a (NLM)33994288 | ||
035 | |a (PII)S0954-6111(21)00138-4 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 1 | |a Wilfong, Erin M |e verfasserin |4 aut | |
245 | 1 | 0 | |a Anti-tRNA synthetase syndrome interstitial lung disease |b A single center experience |
264 | 1 | |c 2022 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ƒaComputermedien |b c |2 rdamedia | ||
338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
500 | |a Date Completed 31.03.2022 | ||
500 | |a Date Revised 16.07.2022 | ||
500 | |a published: Print-Electronic | ||
500 | |a Citation Status MEDLINE | ||
520 | |a Copyright © 2021 The Author(s). Published by Elsevier Ltd.. All rights reserved. | ||
520 | |a BACKGROUND: Recognition of Anti-tRNA synthetase (ARS) related interstitial lung disease (ILD) is key to ensuring patients have prompt access to immunosuppressive therapies. The purpose of this retrospective cohort study was to identify factors that may delay recognition of ARS-ILD | ||
520 | |a METHODS: Patients seen at Vanderbilt University Medical Center between 9/17/2017-10/31/2018 were included in this observational cohort. Clinical and laboratory features were obtained via chart abstraction. Kruskal-Wallis ANOVA, Mann-Whitney U, and Fisher's exact t tests were utilized to determine statistical significance | ||
520 | |a RESULTS: Patients with ARS were found to have ILD in 51.9% of cases, which was comparable to the frequency of ILD in systemic sclerosis (59.5%). The severity of FVC reduction in ARS (53.2%) was comparable to diffuse cutaneous systemic sclerosis (56.8%, p = 0.48) and greater than dermatomyositis (66.9%, p = 0.005) or limited cutaneous systemic sclerosis (71.8%, p = 0.005). Frank honeycombing was seen with ARS antibodies but not other myositis autoantibodies. ARS patients were more likely to first present to a pulmonary provider in a tertiary care setting (53.6%), likely due to fewer extrapulmonary manifestations. Only 33% of ARS-ILD were anti-nuclear antibody, rheumatoid factor, or anti-cyclic citrullinated peptide positive. Patients with ARS-ILD had a two-fold longer median time to diagnosis compared to other myositis-ILD patients (11.0 months, IQR 8.5-43 months vs. 5.0 months, IQR 3.0-9.0 months, p = 0.003) | ||
520 | |a CONCLUSIONS: ARS patients without prominent extra-pulmonary manifestations are at high risk for not being recognized as having a connective tissue disease related ILD and miscategorized as usual interstitial pneumonia/idiopathic pulmonary fibrosis without comprehensive serologies | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a Observational Study | |
650 | 4 | |a Research Support, N.I.H., Extramural | |
650 | 4 | |a Research Support, Non-U.S. Gov't | |
650 | 4 | |a Anti-tRNA synthetase syndrome | |
650 | 4 | |a Connective tissue disease related interstitial lung disease | |
650 | 4 | |a Idiopathic inflammatory myopathies | |
650 | 4 | |a Systemic sclerosis | |
650 | 4 | |a Usual interstitial pneumonia | |
650 | 7 | |a Autoantibodies |2 NLM | |
650 | 7 | |a Amino Acyl-tRNA Synthetases |2 NLM | |
650 | 7 | |a EC 6.1.1.- |2 NLM | |
700 | 1 | |a Young-Glazer, Jennifer J |e verfasserin |4 aut | |
700 | 1 | |a Sohn, Bret K |e verfasserin |4 aut | |
700 | 1 | |a Schroeder, Gabriel |e verfasserin |4 aut | |
700 | 1 | |a Annapureddy, Narender |e verfasserin |4 aut | |
700 | 1 | |a Gillaspie, Erin A |e verfasserin |4 aut | |
700 | 1 | |a Barnado, April |e verfasserin |4 aut | |
700 | 1 | |a Crofford, Leslie J |e verfasserin |4 aut | |
700 | 1 | |a Dudenhofer, Rosemarie Beckford |e verfasserin |4 aut | |
773 | 0 | 8 | |i Enthalten in |t Respiratory medicine |d 1993 |g 191(2022) vom: 13. Jan., Seite 106432 |w (DE-627)NLM012605247 |x 1532-3064 |7 nnns |
773 | 1 | 8 | |g volume:191 |g year:2022 |g day:13 |g month:01 |g pages:106432 |
856 | 4 | 0 | |u http://dx.doi.org/10.1016/j.rmed.2021.106432 |3 Volltext |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_NLM | ||
951 | |a AR | ||
952 | |d 191 |j 2022 |b 13 |c 01 |h 106432 |