Recent developments in in vitro and in vivo models for improved translation of preclinical pharmacokinetics and pharmacodynamics data
Improved pharmacokinetics/pharmacodynamics (PK/PD) prediction in the early stages of drug development is essential to inform lead optimization strategies and reduce attrition rates. Recently, there have been significant advancements in the development of new in vitro and in vivo strategies to better characterize pharmacokinetic properties and efficacy of drug leads. Herein, we review advances in experimental and mathematical models for clearance predictions, advancements in developing novel tools to capture slowly metabolized drugs, in vivo model developments to capture human etiology for supporting drug development, limitations and gaps in these efforts, and a perspective on the future in the field.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:53 |
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| Enthalten in: |
Drug metabolism reviews - 53(2021), 2 vom: 01. Mai, Seite 207-233 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Yadav, Jaydeep [VerfasserIn] |
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| Links: |
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| Themen: |
Clearance prediction |
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| Anmerkungen: |
Date Completed 04.04.2022 Date Revised 22.07.2022 published: Print-Electronic Citation Status PubMed-not-MEDLINE |
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| doi: |
10.1080/03602532.2021.1922435 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM325404526 |
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| 520 | |a Improved pharmacokinetics/pharmacodynamics (PK/PD) prediction in the early stages of drug development is essential to inform lead optimization strategies and reduce attrition rates. Recently, there have been significant advancements in the development of new in vitro and in vivo strategies to better characterize pharmacokinetic properties and efficacy of drug leads. Herein, we review advances in experimental and mathematical models for clearance predictions, advancements in developing novel tools to capture slowly metabolized drugs, in vivo model developments to capture human etiology for supporting drug development, limitations and gaps in these efforts, and a perspective on the future in the field | ||
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| 700 | 1 | |a Lauschke, Volker M |e verfasserin |4 aut | |
| 700 | 1 | |a Hartman, Jessica H |e verfasserin |4 aut | |
| 700 | 1 | |a Russell, Laura E |e verfasserin |4 aut | |
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