Clinical characteristics and outcome of bacteraemia caused by Enterobacter cloacae and Klebsiella aerogenes : more similarities than differences
Copyright © 2021 The Authors. Published by Elsevier Ltd.. All rights reserved..
OBJECTIVES: The genus Enterobacter is a common cause of nosocomial infections. Historically, the most frequent Enterobacter species were those of Enterobacter cloacae complex and Enterobacter aerogenes. In 2019, E. aerogenes was re-classified as Klebsiella aerogenes owing to its higher genotypic similarity with the genus Klebsiella. Our objective was to characterise and compare the clinical profiles of bacteraemia caused by E. cloacae and K. aerogenes.
METHODS: This 3-year multicentre, prospective cohort study enrolled consecutive patients with bacteraemia by E. cloacae or K. aerogenes. Baseline characteristics, bacteraemia features (source, severity, treatment), antibiotic susceptibility, resistance mechanisms and mortality were analysed.
RESULTS: The study included 285 patients with bacteraemia [196 (68.8%) E. cloacae and 89 (31.2%) K. aerogenes]. The groups showed no differences in age, sex, previous use of invasive devices, place of acquisition, sources or severity at onset. The Charlson score was higher among patients with E. cloacae bacteraemia [2 (1-4) vs. 1 (0.5-3); P = 0.018], and previous antibiotic therapy was more common in patients with K. aerogenes bacteraemia (57.3% vs. 41.3%; P = 0.01). Mortality was 19.4% for E. cloacae and 20.2% for K. aerogenes (P = 0.869). Antibiotic susceptibility was similar for both species, and the incidence of multidrug resistance or ESBL production was low (6% and 5.3%, respectively), with no differences between species.
CONCLUSION: Bacteraemias caused by E. cloacae and K. aerogenes share similar patient profiles, presentation and prognosis. Patients with E. cloacae bacteraemia had more co-morbidities and those with K. aerogenes bacteraemia had received more antibiotics.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:25 |
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| Enthalten in: |
Journal of global antimicrobial resistance - 25(2021) vom: 28. Juni, Seite 351-358 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Álvarez-Marín, Rocío [VerfasserIn] |
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| Links: |
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| Themen: |
Bacteraemia |
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| Anmerkungen: |
Date Completed 01.07.2021 Date Revised 31.05.2022 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.jgar.2021.04.008 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM325161666 |
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| 024 | 7 | |a 10.1016/j.jgar.2021.04.008 |2 doi | |
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| 041 | |a eng | ||
| 100 | 1 | |a Álvarez-Marín, Rocío |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Clinical characteristics and outcome of bacteraemia caused by Enterobacter cloacae and Klebsiella aerogenes |b more similarities than differences |
| 264 | 1 | |c 2021 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
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| 500 | |a Date Completed 01.07.2021 | ||
| 500 | |a Date Revised 31.05.2022 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2021 The Authors. Published by Elsevier Ltd.. All rights reserved. | ||
| 520 | |a OBJECTIVES: The genus Enterobacter is a common cause of nosocomial infections. Historically, the most frequent Enterobacter species were those of Enterobacter cloacae complex and Enterobacter aerogenes. In 2019, E. aerogenes was re-classified as Klebsiella aerogenes owing to its higher genotypic similarity with the genus Klebsiella. Our objective was to characterise and compare the clinical profiles of bacteraemia caused by E. cloacae and K. aerogenes | ||
| 520 | |a METHODS: This 3-year multicentre, prospective cohort study enrolled consecutive patients with bacteraemia by E. cloacae or K. aerogenes. Baseline characteristics, bacteraemia features (source, severity, treatment), antibiotic susceptibility, resistance mechanisms and mortality were analysed | ||
| 520 | |a RESULTS: The study included 285 patients with bacteraemia [196 (68.8%) E. cloacae and 89 (31.2%) K. aerogenes]. The groups showed no differences in age, sex, previous use of invasive devices, place of acquisition, sources or severity at onset. The Charlson score was higher among patients with E. cloacae bacteraemia [2 (1-4) vs. 1 (0.5-3); P = 0.018], and previous antibiotic therapy was more common in patients with K. aerogenes bacteraemia (57.3% vs. 41.3%; P = 0.01). Mortality was 19.4% for E. cloacae and 20.2% for K. aerogenes (P = 0.869). Antibiotic susceptibility was similar for both species, and the incidence of multidrug resistance or ESBL production was low (6% and 5.3%, respectively), with no differences between species | ||
| 520 | |a CONCLUSION: Bacteraemias caused by E. cloacae and K. aerogenes share similar patient profiles, presentation and prognosis. Patients with E. cloacae bacteraemia had more co-morbidities and those with K. aerogenes bacteraemia had received more antibiotics | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Multicenter Study | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Bacteraemia | |
| 650 | 4 | |a Case–control study | |
| 650 | 4 | |a Enterobacter aerogenes | |
| 650 | 4 | |a Enterobacter cloacae | |
| 650 | 4 | |a Klebsiella aerogenes | |
| 650 | 4 | |a Quinolone resistance mechanism | |
| 700 | 1 | |a Lepe, José Antonio |e verfasserin |4 aut | |
| 700 | 1 | |a Gasch-Blasi, Oriol |e verfasserin |4 aut | |
| 700 | 1 | |a Rodríguez-Martínez, José Manuel |e verfasserin |4 aut | |
| 700 | 1 | |a Calvo-Montes, Jorge |e verfasserin |4 aut | |
| 700 | 1 | |a Lara-Contreras, Rosario |e verfasserin |4 aut | |
| 700 | 1 | |a Martín-Gandul, Cecilia |e verfasserin |4 aut | |
| 700 | 1 | |a Tubau-Quintano, Fe |e verfasserin |4 aut | |
| 700 | 1 | |a Cano-García, María Eliecer |e verfasserin |4 aut | |
| 700 | 1 | |a Rodríguez-López, Fernando |e verfasserin |4 aut | |
| 700 | 1 | |a Rodríguez-Baño, Jesús |e verfasserin |4 aut | |
| 700 | 1 | |a Pujol-Rojo, Miquel |e verfasserin |4 aut | |
| 700 | 1 | |a Torre-Cisneros, Julián |e verfasserin |4 aut | |
| 700 | 1 | |a Martínez-Martínez, Luis |e verfasserin |4 aut | |
| 700 | 1 | |a Pascual-Hernández, Álvaro |e verfasserin |4 aut | |
| 700 | 1 | |a Jiménez-Mejías, Manuel E |e verfasserin |4 aut | |
| 700 | 0 | |a Spanish Network for Research in Infectious Diseases/Enterobacter spp. Bacteriemia Project Group |e verfasserin |4 aut | |
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