Differential role of sphingomyelin in influenza virus, rhinovirus and SARS-CoV-2 infection of Calu-3 cells
Host cell lipids play a pivotal role in the pathogenesis of respiratory virus infection. However, a direct comparison of the lipidomic profile of influenza virus and rhinovirus infections is lacking. In this study, we first compared the lipid profile of influenza virus and rhinovirus infection in a bronchial epithelial cell line. Most lipid features were downregulated for both influenza virus and rhinovirus, especially for the sphingomyelin features. Pathway analysis showed that sphingolipid metabolism was the most perturbed pathway. Functional study showed that bacterial sphingomyelinase suppressed influenza virus and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) replication, but promoted rhinovirus replication. These findings suggest that sphingomyelin pathway can be a potential target for antiviral therapy, but should be carefully evaluated as it has opposite effects on different respiratory viruses. Furthermore, the differential effect of sphingomyelinase on rhinovirus and influenza virus may explain the interference between rhinovirus and influenza virus infection.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:102 |
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| Enthalten in: |
The Journal of general virology - 102(2021), 5 vom: 24. Mai |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Dissanayake, Thrimendra Kaushika [VerfasserIn] |
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| Links: |
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| Themen: |
EC 3.1.4.12 |
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| Anmerkungen: |
Date Completed 19.05.2021 Date Revised 07.12.2022 published: Print Citation Status MEDLINE |
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| doi: |
10.1099/jgv.0.001593 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM325085560 |
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| 100 | 1 | |a Dissanayake, Thrimendra Kaushika |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Differential role of sphingomyelin in influenza virus, rhinovirus and SARS-CoV-2 infection of Calu-3 cells |
| 264 | 1 | |c 2021 | |
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| 500 | |a Date Completed 19.05.2021 | ||
| 500 | |a Date Revised 07.12.2022 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Host cell lipids play a pivotal role in the pathogenesis of respiratory virus infection. However, a direct comparison of the lipidomic profile of influenza virus and rhinovirus infections is lacking. In this study, we first compared the lipid profile of influenza virus and rhinovirus infection in a bronchial epithelial cell line. Most lipid features were downregulated for both influenza virus and rhinovirus, especially for the sphingomyelin features. Pathway analysis showed that sphingolipid metabolism was the most perturbed pathway. Functional study showed that bacterial sphingomyelinase suppressed influenza virus and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) replication, but promoted rhinovirus replication. These findings suggest that sphingomyelin pathway can be a potential target for antiviral therapy, but should be carefully evaluated as it has opposite effects on different respiratory viruses. Furthermore, the differential effect of sphingomyelinase on rhinovirus and influenza virus may explain the interference between rhinovirus and influenza virus infection | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a SARS-CoV-2 | |
| 650 | 4 | |a influenza | |
| 650 | 4 | |a lipidomics | |
| 650 | 4 | |a rhinovirus | |
| 650 | 4 | |a sphingomyelin | |
| 650 | 4 | |a sphingomyelinase | |
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| 650 | 7 | |a Sphingomyelin Phosphodiesterase |2 NLM | |
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| 700 | 1 | |a Yan, Bingpeng |e verfasserin |4 aut | |
| 700 | 1 | |a Ng, Anthony Chin-Ki |e verfasserin |4 aut | |
| 700 | 1 | |a Zhao, Hanjun |e verfasserin |4 aut | |
| 700 | 1 | |a Chan, Gabriella |e verfasserin |4 aut | |
| 700 | 1 | |a Yip, Cyril Chik-Yan |e verfasserin |4 aut | |
| 700 | 1 | |a Sze, Kong-Hung |e verfasserin |4 aut | |
| 700 | 1 | |a To, Kelvin Kai-Wang |e verfasserin |4 aut | |
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