Sex-specific impact of severe obesity in the outcomes of hospitalized patients with COVID-19 : a large retrospective study from the Bronx, New York
© 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature..
It has been demonstrated that obesity is an independent risk factor for worse outcomes in patients with COVID-19. Our objectives were to investigate which classes of obesity are associated with higher in-hospital mortality and to assess the association between obesity and systemic inflammation. This was a retrospective study which included consecutive hospitalized patients with COVID-19 in a tertiary center. Three thousand five hundred thirty patients were included in this analysis (female sex: 1579, median age: 65 years). The median body mass index (BMI) was 28.8 kg/m2. In the overall cohort, a J-shaped association between BMI and in-hospital mortality was depicted. In the subgroup of men, BMI 35-39.9 kg/m2 and BMI ≥40 kg/m2 were found to have significant association with higher in-hospital mortality, while only BMI ≥40 kg/m2 was found significant in the subgroup of women. No significant association between BMI and IL-6 was noted. Obesity classes II and III in men and obesity class III in women were independently associated with higher in-hospital mortality in patients with COVID-19. The male population with severe obesity was the one that mainly drove this association. No significant association between BMI and IL-6 was noted.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:40 |
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| Enthalten in: |
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology - 40(2021), 9 vom: 06. Sept., Seite 1963-1974 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Guerson-Gil, Arcelia [VerfasserIn] |
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| Links: |
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| Themen: |
COVID-19 |
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| Anmerkungen: |
Date Completed 16.08.2021 Date Revised 18.02.2022 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1007/s10096-021-04260-z |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM325082553 |
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| 245 | 1 | 0 | |a Sex-specific impact of severe obesity in the outcomes of hospitalized patients with COVID-19 |b a large retrospective study from the Bronx, New York |
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| 520 | |a © 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. | ||
| 520 | |a It has been demonstrated that obesity is an independent risk factor for worse outcomes in patients with COVID-19. Our objectives were to investigate which classes of obesity are associated with higher in-hospital mortality and to assess the association between obesity and systemic inflammation. This was a retrospective study which included consecutive hospitalized patients with COVID-19 in a tertiary center. Three thousand five hundred thirty patients were included in this analysis (female sex: 1579, median age: 65 years). The median body mass index (BMI) was 28.8 kg/m2. In the overall cohort, a J-shaped association between BMI and in-hospital mortality was depicted. In the subgroup of men, BMI 35-39.9 kg/m2 and BMI ≥40 kg/m2 were found to have significant association with higher in-hospital mortality, while only BMI ≥40 kg/m2 was found significant in the subgroup of women. No significant association between BMI and IL-6 was noted. Obesity classes II and III in men and obesity class III in women were independently associated with higher in-hospital mortality in patients with COVID-19. The male population with severe obesity was the one that mainly drove this association. No significant association between BMI and IL-6 was noted | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a COVID-19 | |
| 650 | 4 | |a IL-6 | |
| 650 | 4 | |a Inflammation | |
| 650 | 4 | |a Mortality | |
| 650 | 4 | |a Novel coronavirus | |
| 650 | 4 | |a Obesity | |
| 650 | 4 | |a Observational study | |
| 650 | 4 | |a Risk factor | |
| 650 | 4 | |a SARS-CoV-2 | |
| 700 | 1 | |a Palaiodimos, Leonidas |e verfasserin |4 aut | |
| 700 | 1 | |a Assa, Andrei |e verfasserin |4 aut | |
| 700 | 1 | |a Karamanis, Dimitris |e verfasserin |4 aut | |
| 700 | 1 | |a Kokkinidis, Damianos |e verfasserin |4 aut | |
| 700 | 1 | |a Chamorro-Pareja, Natalia |e verfasserin |4 aut | |
| 700 | 1 | |a Kishore, Preeti |e verfasserin |4 aut | |
| 700 | 1 | |a Leider, Jason M |e verfasserin |4 aut | |
| 700 | 1 | |a Brandt, Lawrence J |e verfasserin |4 aut | |
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