Cardiometabolic Therapy and Mortality in Very Old Patients With Diabetes Hospitalized due to COVID-19
© The Author(s) 2021. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissionsoup.com..
BACKGROUND: The effects of cardiometabolic drugs on the prognosis of diabetic patients with COVID-19, especially very old patients, are not well known. This work was aimed to analyze the association between preadmission cardiometabolic therapy (antidiabetic, antiaggregant, antihypertensive, and lipid-lowering drugs) and in-hospital mortality among patients ≥80 years with type 2 diabetes mellitus (T2DM) hospitalized for COVID-19.
METHOD: We conducted a nationwide, multicenter, observational study in patients ≥80 years with T2DM hospitalized for COVID-19 between March 1 and May 29, 2020. The primary outcome measure was in-hospital mortality. A multivariate logistic regression analysis was performed to assess the association between preadmission cardiometabolic therapy and in-hospital mortality.
RESULTS: Of the 2 763 patients ≥80 years old hospitalized due to COVID-19, 790 (28.6%) had T2DM. Of these patients, 385 (48.7%) died during admission. On the multivariate analysis, the use of dipeptidyl peptidase-4 inhibitors (adjusted odds ratio [AOR] 0.502, 95% confidence interval [CI]: 0.309-0.815, p = .005) and angiotensin receptor blockers (AOR 0.454, 95% CI: 0.274-0.759, p = .003) were independent protectors against in-hospital mortality, whereas the use of acetylsalicylic acid was associated with higher in-hospital mortality (AOR 1.761, 95% CI: 1.092-2.842, p = .020). Other antidiabetic drugs, angiotensin-converting enzyme inhibitors, and statins showed neutral association with in-hospital mortality.
CONCLUSIONS: We found important differences between cardiometabolic drugs and in-hospital mortality in older patients with T2DM hospitalized for COVID-19. Preadmission treatment with dipeptidyl peptidase-4 inhibitors and angiotensin receptor blockers could reduce in-hospital mortality; other antidiabetic drugs, angiotensin-converting enzyme inhibitors, and statins seem to have a neutral effect; and acetylsalicylic acid could be associated with excess mortality.
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E-Artikel |
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Erscheinungsjahr: |
2021 |
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Erschienen: |
2021 |
Enthalten in: |
Zur Gesamtaufnahme - volume:76 |
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Enthalten in: |
The journals of gerontology. Series A, Biological sciences and medical sciences - 76(2021), 8 vom: 13. Juli, Seite e102-e109 |
Sprache: |
Englisch |
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Anmerkungen: |
Date Completed 29.07.2021 Date Revised 29.07.2021 published: Print Citation Status MEDLINE |
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doi: |
10.1093/gerona/glab124 |
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PPN (Katalog-ID): |
NLM324985762 |
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100 | 1 | |a Ramos-Rincón, Jose Manuel |e verfasserin |4 aut | |
245 | 1 | 0 | |a Cardiometabolic Therapy and Mortality in Very Old Patients With Diabetes Hospitalized due to COVID-19 |
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520 | |a © The Author(s) 2021. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissionsoup.com. | ||
520 | |a BACKGROUND: The effects of cardiometabolic drugs on the prognosis of diabetic patients with COVID-19, especially very old patients, are not well known. This work was aimed to analyze the association between preadmission cardiometabolic therapy (antidiabetic, antiaggregant, antihypertensive, and lipid-lowering drugs) and in-hospital mortality among patients ≥80 years with type 2 diabetes mellitus (T2DM) hospitalized for COVID-19 | ||
520 | |a METHOD: We conducted a nationwide, multicenter, observational study in patients ≥80 years with T2DM hospitalized for COVID-19 between March 1 and May 29, 2020. The primary outcome measure was in-hospital mortality. A multivariate logistic regression analysis was performed to assess the association between preadmission cardiometabolic therapy and in-hospital mortality | ||
520 | |a RESULTS: Of the 2 763 patients ≥80 years old hospitalized due to COVID-19, 790 (28.6%) had T2DM. Of these patients, 385 (48.7%) died during admission. On the multivariate analysis, the use of dipeptidyl peptidase-4 inhibitors (adjusted odds ratio [AOR] 0.502, 95% confidence interval [CI]: 0.309-0.815, p = .005) and angiotensin receptor blockers (AOR 0.454, 95% CI: 0.274-0.759, p = .003) were independent protectors against in-hospital mortality, whereas the use of acetylsalicylic acid was associated with higher in-hospital mortality (AOR 1.761, 95% CI: 1.092-2.842, p = .020). Other antidiabetic drugs, angiotensin-converting enzyme inhibitors, and statins showed neutral association with in-hospital mortality | ||
520 | |a CONCLUSIONS: We found important differences between cardiometabolic drugs and in-hospital mortality in older patients with T2DM hospitalized for COVID-19. Preadmission treatment with dipeptidyl peptidase-4 inhibitors and angiotensin receptor blockers could reduce in-hospital mortality; other antidiabetic drugs, angiotensin-converting enzyme inhibitors, and statins seem to have a neutral effect; and acetylsalicylic acid could be associated with excess mortality | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a Multicenter Study | |
650 | 4 | |a Observational Study | |
650 | 4 | |a Age ≥ 80 | |
650 | 4 | |a Cardiometabolic therapy | |
650 | 4 | |a Coronavirus disease-2019 | |
650 | 4 | |a Mortality | |
650 | 4 | |a Type 2 diabetes | |
650 | 7 | |a Angiotensin Receptor Antagonists |2 NLM | |
650 | 7 | |a Dipeptidyl-Peptidase IV Inhibitors |2 NLM | |
650 | 7 | |a Hypoglycemic Agents |2 NLM | |
700 | 1 | |a Pérez-Belmonte, Luis M |e verfasserin |4 aut | |
700 | 1 | |a Carrasco-Sánchez, Francisco Javier |e verfasserin |4 aut | |
700 | 1 | |a Jansen-Chaparro, Sergio |e verfasserin |4 aut | |
700 | 1 | |a De-Sousa-Baena, Mercedes |e verfasserin |4 aut | |
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700 | 1 | |a Arévalo-Cañas, Coral |e verfasserin |4 aut | |
700 | 1 | |a Bacete Cebrian, Marta |e verfasserin |4 aut | |
700 | 1 | |a Méndez-Bailón, Manuel |e verfasserin |4 aut | |
700 | 1 | |a Fiteni Mera, Isabel |e verfasserin |4 aut | |
700 | 1 | |a González García, Andrés |e verfasserin |4 aut | |
700 | 1 | |a Navarro Romero, Francisco |e verfasserin |4 aut | |
700 | 1 | |a Tuñón de Almeida, Carlota |e verfasserin |4 aut | |
700 | 1 | |a Muñiz Nicolás, Gemma |e verfasserin |4 aut | |
700 | 1 | |a González Noya, Amara |e verfasserin |4 aut | |
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700 | 1 | |a García García, Gema María |e verfasserin |4 aut | |
700 | 1 | |a Alcalá Pedrajas, José Nicolás |e verfasserin |4 aut | |
700 | 1 | |a Herrero García, Virginia |e verfasserin |4 aut | |
700 | 1 | |a Corral-Gudino, Luis |e verfasserin |4 aut | |
700 | 1 | |a Comas Casanova, Pere |e verfasserin |4 aut | |
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